Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype1-3. To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor het

Using tethered American cockroaches walking on a trackball in a spherical virtual reality environment, we tested optomotor responses to horizontally moving black-and-white gratings of different vertical extent under six different light intensities. We found that shortening the vertical extent of the wide-field stimulus grating within a light level weakened response strength, reduced average veloci

I antologin är kapitel samlade som ut olika perspektiv behandlar undervisning och lärande i musik samt musiklärares professionsutveckling. Karl Asp problematiserar genrebegreppet och exemplifierar hur det är möjligt att planera sin musikundervisning utifrån resonemang om vad genre kan tänkas vara och innebära. Konsekvenser av genrer och de praktiker som kan uppstå i ensembleundervisning när det gä

The analysis departs from the FCC’s stringent proportionality review to elaborate an argument on what intensity of review should be adopted when reviewing the ECB’s economic policies. Building on previous scholarly analyses (Öberg) and relevant Court case law( Spain v Council and Vodafone,) it suggests that the proper standard of proportionality analysis should primarily be guided by the nature of

Lignin is the second most abundant biopolymer in nature and a promising renewable resource for aromatic chemicals. For the understanding of different lignin isolation and conversion processes, the identification of phenolic compounds is of importance. However, due to the vast number of possible chemical transformations, the prediction of produced phenolic structures is challenging, and a non-targe

After the fall of the Berlin wall and the end of the Cold War, a certain sense of optimism swept across Europe. Some 25 years later, everything seems radically different. With the considerable inroads made into mainstream politics by right-wing populist parties across the continent, there is no shortage of gloom and worry. Nevertheless, despite numerous examples of retrogressive forms of mobilizat

This paper proposes a relational time-geography approach to differentiate the geographies of recreational activities, whose place cannot be pinned down to a single specific infrastructure or area and therefore risks being marginalised in planning. Running is used as a case study. Based on diary-interviews, we have identified three different exercises/places used alternately by the respondents: the

This contribution examines, in the Central and Eastern European context, the interplay between ideals of national specificity, welfare chauvinist appeals, and emerging politics of migration, for the purpose of providing welfare provision to a narrowly defined ethnic group, as promoted by right-wing populist parties in the region. We suggest a comparative framework to account the various positions

Geospatial information plays an indispensable role in various interdisciplinary and spatially informed analyses. However, the use of geospatial information often entails many semantic intricacies relating to, among other issues, data integration and visualization. For the integration of data from different domains, merely using ontologies is inadequate for handling subtle and complex semantic rela

In this study, Spatial Multi-Criteria Evaluation and the least cost path analysis were applied to find the optimal by-pass road alignment in the Tlokweng Planning Area in Botswana. One-At-a-Time sensitivity analysis and the statistical test for zero proportion were used to investigate the robustness of the entire model. Four alternative by-pass roads were produced stressing economic, environmental