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The expansion of knowledge regarding driver mutations for Wilms tumor (WT) and malignant rhabdoid tumor of the kidney (MRT) and various translocations for other pediatric renal tumors opens up new possibilities for diagnosis and treatment. In addition, there are growing data surrounding prognostic factors that can be used to stratify WT treatment to improve outcomes. Here, we review the molecular
Background: Corticosteroids play a significant role in managing the vast majority of inflammatory and immunologic conditions. To date, population-based studies on knowledge and attitudes concerning corticosteroids are scarce. This study aims to comprehensively assess knowledge, perception, experience and phobia toward corticosteroid use among the general population in the era of COVID-19. Methods:
Cancer is a multifactorial, complex disease exhibiting extraordinary phenotypic plasticity and diversity. One of the greatest challenges in cancer treatment is intratumoral heterogeneity, which obstructs the efficient eradication of the tumor. Tumor heterogeneity is often associated with the presence of cancer stem cells (CSCs), a cancer cell sub-population possessing a panel of stem-like properti
A monotone Boolean circuit is composed of OR gates, AND gates and input gates corresponding to the input variables and the Boolean constants. It is multilinear if for any AND gate the two input functions have no variable in common. We consider a generalization of monotone multilinear Boolean circuits to include monotone q-multilinear Boolean circuits. Roughly, a sufficient condition for the q-mult
Background: People with psychiatric disabilities often find it difficult to maintain a satisfactory occupational balance. Aims/objectives: This study aimed to investigate the validity and reliability of the Turkish version of the Occupational Balance Questionnaire (OBQ11-T) in mental health. Material and methods: OBQ11-T was applied to 149 people for construct validity analysis and to 61 of them f
In order to solve the problem of the uneven distribution of the flow and ammonia concentration field in the selective catalytic reduction (SCR) denitrification system of a 660 MW coal-fired power plant, a three-dimensional computational fluid dynamics (CFD) model was established at a scale of 1:1. The existing flow guide and ammonia fume mixing device were then calibrated and optimized. The relati
Anastomotic defect (AD) after esophagectomy can lead to severe complications with need for surgical or endoscopic intervention. Early detection enables early treatment and can limit the consequences of the AD. As of today, there are limited methods to predict AD. In this study, we have used microdialysis (MD) to measure local metabolism at the intrathoracic anastomosis. Feasibility and possible di
Cleft lip and palate (CL/P) is the most common congenital craniofacial malformation and is often associated with additional diagnoses. The purpose of this study was to explore the cumulative five-year incidence of additional diagnoses for patients with cleft lip and palate. Further aims were, type of cleft and type of additional diagnose and to validate CLP registry data on additional diagnoses. D
This chapter is based on responses from 147 IHL and military ethics educators from around the world to a survey designed to elicit their views on the relationship between the teaching of IHL and ethics in military education. The study was initiated in response to discussions with colleagues teaching law and ethics which highlighted perceived gaps between the teaching of the subjects. The responses
Leaf functional traits are key indicators of plant functions useful for inferring complex plant processes, including their responses to environmental changes. Vegetation indices (VIs) composed of a few reflectance wavelengths hold the advantages of being relatively simple and effective and have been widely used within remote sensing to estimate leaf traits. However, the difference between the refl
Familial forms of monoclonal gammopathy, defined as multiple myeloma (MM) or Monoclonal Gammopathy of Undetermined Significance (MGUS), are relatively infrequent and most series reported in the literature describe a limited number of families. MM rarely occurs in a familial context. MGUS is observed much more commonly, which can in some cases evolve toward full-blown MM. Although recurrent cytogen
Cisplatin, a platinum-based chemotherapeutic agent, is widely used as a front-line treatment for several malignancies. However, treatment outcomes vary widely due to intrinsic and acquired resistance. In this study, cisplatin-perturbed gene expression and pathway enrichment were used to define a gene signature, which was further utilized to develop a cisplatin sensitivity prediction model using th
Although the Red Army left the Danish island of Bornholm 76 years ago, the Russian invasion of Ukraine has brought the memories of those events to life again. This small island, stretched between Sweden and Poland and not so far away from Kaliningrad Oblast, is rediscovering the meaning of its recent past. Miłosz Jeromin Cordes met with Jakob Seerup, a PhD, researcher and curator at Bornholm’s Mus
Maxillary growth inhibition in patients with cleft lip and palate (CLP) is an undesired effect that may occur in the teens despite proper primary care. Dental malocclusion and distortion of facial appearance can be treated with external distraction osteogenesis (DO) of the maxilla. This entails a Le Fort I osteotomy, fastening a semi-circular distractor to the skull, distraction for three weeks, a
Enterococcus faecalis cells can reduce ferric ions and other electron acceptors by extracellular electron transfer (EET). To find mutants with enhanced or defective EET, strain OG1RF with random transposon insertions in the chromosome was screened for ferric reductase activity by colony zymogram staining using the chromogenic ferrous-chelating compound Ferrozine. The screen revealed npr, eetB, and
Purpose: Environmental factors contribute substantially to risk for drug use disorders (DUD). The current study applies multiple methods to empirically test whether military service is associated with subsequent DUD, as previous findings are inconsistent. Methods: Longitudinal Swedish national registry data on a cohort of male conscripts born 1972–1987 (maximum N = 485,900) were used to test the a
This text focuses on the presence of calcium and phosphorus in connection with copper-alloy residue on the inside of melting crucibles from south Sweden dated to the late Bronze Age (ca. 1100 - 500 BC). The increase of Ca and P on the crucibles is not seen in general or overall but instead observed as a relative increase only on the inside were the metal was melted. The authors of this article wis
When Gomułka came to power, cruises to the West, mainly on the Baltic Sea, were allowed on the "Mazowsze" tourist ship. It usually passed Bornholm and moored at a safe distance from the island, so that cruisers could see the hostile West, but they did not taste it. In August 1957, on the first day of the layover, two young men jumped off the ship and swam a few hundred meters to Snogebaek south of
Abstract: Optical flow provides an opportunity to elevate the resolution and sensitivity of deflection sensing in background-oriented schlieren (BOS). Despite extensive relevant literature within the field of computer vision, there is a lack of proper quantification of its abilities and limitations with regard to the state-of-the-art BOS experiments. Thus, this study performs an assessment of accu
