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Myostatin negatively regulates skeletal muscle size in multiple species, and therefore, myostatin blockade has been therapeutically explored to promote muscle growth in humans, including to counter the muscle loss seen in obese humans using GLP1R agonists. In this study, we present results from a large multi-cohort genetic association analysis, using data from 1.1 million individuals to examine th
Previous experimental studies of pyrrole pyrolysis reported numerous hydrocarbon and nitrogen-containing products from HCN up to pyridine and dinitriles. To develop a consistent detailed kinetic mechanism for pyrrole, the rate constants of H atom abstraction from C4H5N by NH2, and CH2CN radicals have been calculated at the DLPNO-CCSD(T)-F12/cc-pVDZ-F12//M06–2X/def2-TZVP level of theory while H ato
Background and purpose: Claudin-5 plays a crucial role in maintaining blood-brain barrier (BBB) integrity through endothelial tight junction formation. Alternative splicing of claudin-5 within the microvascular endothelium may modulate BBB structural and functional dynamics, thereby affecting neuronal damage and recovery after ischemic stroke. The aim of this study was to investigate temporal and
This bachelor thesis examines how Sámi women and queer Sámi people's vulnerabilization is constructed through an indigenous feminist and western politics discourse in the report called Violence against Sámi women (Våld mot samiska kvinnor). By using critical discourse analysis and Fairclough’s three-dimensional model, the thesis shows that the report constructs Sámi women's vulnerabilizati
This thesis investigates the development of an object-oriented modular framework for PLC systems, intended for use at Etteplan, an international engineering consultancy. The thesis was motivated by recurring challenges in PLC projects, including unclear program flows, low code reusability, and limited scalability. These issues justify the need for a standardized framework grounded in the IEC 61131
Detta examensarbete tar fram ett förslag för en ny arena vid Norra Hovstallängen i Uppsala och undersöker hur en storskalig evenemangs- och idrottsbyggnad kan integreras i en av stadens mest centrala och strategiskt placerade platser, i nära anslutning till Uppsala centralstation. Platsens läge i staden väcker frågor kring hur en sådan framträdande yta bör användas, och vilket värde en storskalig
Denna studie undersöker hur människors välbefinnande i bostadsområden påverkas av utomhusmiljö och biofilisk design. Vi har valt särskilt fokus på Holma i Malmö, ett område som byggdes under miljonprogrammet. Syftet med studien är att analysera hur Holmas bostadsmiljö förhåller sig till biofilisk design både i nutid och i samband med renoveringar och framtida stadsomvandling. För att genomföra arbThis study examines how people’s well-being in residential areas is affected by the outdoor environments and biophilic design. We have chosen to focus specifically on Holma in Malmö, an area built during the million homes programme era. The aim of the study is to analyze how Holma’s residential environment relates to biophilic design, both in present time and in connection with renovations and pla
Den ökade efterfrågan och turismen i Stockholms skärgård har skapat en identitetsmässig konflikt, där bebyggelseutvecklingen främst drivs av kommersiella besöksnäringar och privata fritidshus. Skärgårdsmiljön balanserar idag mellan strikt skyddade naturområden och exklusiva, privatiserade strandtomter, vilket lämnar lite utrymme för ett levande permanentliv. För att skärgården ska förbli en fungerThe growing demand and tourism in the Stockholm archipelago have created a conflict of identity, where property development is primarily driven by commercial hospitality industries and private seasonal housing. Today, the archipelago environment balances between strictly protected natural areas and exclusive, privatized shorelines, leaving little room for a vibrant, year-round community. For the a
The United Nations is the arena for a renewed push to regulate transnational corporations (TNCs) and their supply chains. This article analyses the ongoing efforts of a multilateral organization to strengthen the human rights legal framework, especially the design choices posed by the treaty negotiations as well as the role of the UN Human Rights Council in the broader regulatory ecosystem around
This chapter introduces US author, journalist, blogger, and futurist Bruce Sterling. Since his science fiction (sf) debut with the story “Man-Made Self” (1976), Bruce Sterling has so far published eleven novels (plus one in collaboration with William Gibson), over 70 pieces of short fiction (not including dozens of collaborations), and a handful of chapbooks in various media, accruing a number of
This article examines the diffusion of meritocratic practices as a potential instance of policy transfer by scrutinizing the introduction of open and competitive examinations during the mid-nineteenth century in the British Civil Service. Scholars have argued that British reformers were inspired by meritocratic practices in British-ruled India. In order to assess this claim, we combine qualitative
The seasonal timing of moult in migratory birds is an adaptation to cope with time constraints in the annual cycle. Kiat and Izhaki analysed moult patterns in Palaearctic passerines and rejected the proposition that seasonally divided moult is an endogenously controlled strategy. Instead, they advocated the view that it occurs due to a flexible and opportunistic timing of moult. In contrast, we ar
