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The Role of Phosphodiesterase 3B in the Regulation of Insulin Secretion

Popular Abstract in Swedish Denna avhandling är en s.k. sammanläggningsavhandling och innehåller tre delarbeten. Delarbete I är publicerat, delarbete II är under revision inför publikation och delarbete III är i manuskriptform. Syftet med mina studier har varit att undersöka regleringen av insulinsekretion från de insulinproducerande cellerna i bukspottkörteln med fokus på ett specifikt protein - Pancreatic beta-cell dysfunction and insulin resistance are the two hallmarks of type 2 diabetes. An early sign of beta-cell dysfunction is impaired nutrient-induced insulin release. Several insulin secretagogues act by increasing the formation of intracellular cAMP. Thus, accurate regulation of cAMP is of vital importance for the ability of the beta-cell to respond properly to these stimuli. The

A World of Tropes?

Abstract in UndeterminedWhy should one hold that the world is a world of tropes? Or, more generally: How do we justify our ontological conclusions? It seems clear that the only evidence at our disposal must belong to appearances. For a realist, however, it is unreasonable to think that our conceptualisation of reality will reveal to us reality as it is independently of how it seems. You simply can

Electrophysiological properties of parallel fiber synapses in vivo

In vitro studies have revealed intriguing properties of parallel fiber synaptic transmisson. Most notably, these synapses have been shown to induce highly variable synaptic responses, have a pronounced paired pulse facilitation and to induce later, variable synaptic responses in their target neurons. In the present study, whole cell recordings from stellate cells and basket cells were made to eval

Comparison of static analysis tools for finding concurrency bugs

This paper highlights the issues of detecting Java concurrency bugs using static code analysis tools. Concurrency bugs are often hard to find because of interleaving threads and there is need to use static analysis tools to detect the concurrency bugs. In the literature review, we established that there are number of static analysis tools such as FindBugs, JLint and Chord, used in experiments to d

Atomic Spectroscopy on Fusion Relevant Ions and Studies of Light Impurities in the JET Tokamak

Popular Abstract in Swedish Kontroll av fororeningar i dagens fusionsmaskiner aer ett inte alltfor stort problem. De kan dock anvandas for diagnostiskt syfte eftersom deras linjeemission avslojar ett flertal intressanta plasmaparametrar. For att kunna maeta egenskaper som jontemperatur, jondensitet och plasmarotation i ett fusionsplasma, aer det av yttersta vikt att den spektroskopiska tolkningen The spectrum and energy levels C IV and the 3l4l' system of the Mg-like ions in the iron group elements has been investigated. This has led to several hundred identified transitions, many of them previously unknown. Using the Charge Exchange diagnostic system at JET, ion temperatures, rotation velocities and densities have been derived from visible spectroscopic measurements on fully ionised light