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The endogenous opioid system (EOS) controls the processing of nociceptive stimuli and is a pharmacological target for opioids. Alterations in expression of the EOS genes under neuropathic pain condition may account for low efficacy of opioid drugs. We here examined whether EOS expression patterns are altered in the lumbar spinal cord of the rats with spinal nerve ligation (SNL) as a neuropathic pa
Objectives: The literature has highlighted the importance of identifying symptoms predictive of acute myocardial infarction (AMI) in women, in addition to traditional cardiovascular risk factors. The objective was to study subjective health problems, in relation to later AMI, in a large sample of women, adjusted for age, educational status, smoking, waist/hip ratio, blood pressure, total cholester
As an effective strategy to control the combustion of advanced combustion modes, the application of variable valve timing (VVT) in reactivity controlled compression ignition (RCCI) combustion was investigated in this study. By coupling KIVA-3V code with genetic algorithm, the combustion of a heavy-duty engine with RCCI combustion combined with VVT strategy was optimized under a wide load range. At
Objective: Investigate the temporal development of EEG and prognosis. Methods: Prospective observational substudy of the Target Temperature Management trial. Six sites performed simplified continuous EEG-monitoring (cEEG) on comatose patients after cardiac arrest, blinded to treating physicians. We determined time-points of recovery of a normal-voltage continuous background activity and the appear
Purpose: To investigate the statistical distribution of the gamma value under error-free conditions, in order to study the relation between the gamma evaluation failure rate and statistically significant deviations in the general situation. Methods: The 2D absorbed dose distribution for 30 clinical head-and-neck IMRT fields were calculated in a QC phantom. For the same fields, dose measurements we
We present the robot developed within the Hobbit project, a socially assistive service robot aiming at the challenge of enabling prolonged independent living of elderly people in their own homes. We present the second prototype (Hobbit PT2) in terms of hardware and functionality improvements following first user studies. Our main contribution lies within the description of all components developed
AIMS: Cardiovascular disease (CVD) is one of the leading causes of mortality and morbidity worldwide, including in Sweden. The main aim of this study was to explore the temporal trends and spatial patterns of CVD in Sweden using spatial autocorrelation analyses.METHODS: The CVD admission rates between 2000 and 2010 throughout Sweden were entered as the input disease data for the analytic processes
Adenosine plays an important role in cell death and differentiation as well as in tumorigenesis and the intra- and extra-cellular levels range from nanomolar to millimolar levels under various physiological or pathophysiological conditions. Here we report that adenosine can activate HPV16 late gene expression in a dose- and time-dependent manner, but only in the presence of guanosine. This activat
Although a number of different medium access control (MAC) schemes are adopted for wireless multi-hop networks, time division multiple access (TDMA) approaches based on a periodic frame of time slots are the most common when very high efficiency is needed in terms of use of radio and energy resources. Efficient resource usage is typically based on parallel compatible transmissions from multiple no
Studies on the natural human exposures to fine particulate matter (PM2.5) and their elements composition are practically non-existent in South America. In order to understand the natural exposure of the typical Brazilian population to PM2.5 and their trace element composition, we measured PM2.5 concentrations and collected mass on filters for nine continuous hours during a typical workday of volun
Three new U–Pb ID-TIMS isotopic ages confirm previous evidence for two geochemically distinct, early Mesoproterozoic pulses of mafic magmatism along the western margin of Laurentia. The first is a U–Pb baddeleyite age of 1590 ± 5 Ma from a dyke swarm in the Tobacco Root Mountains of western Laurentia. It is the first evidence for magmatism of this age in west-central Laurentia. The second is a U–P
Artikeln är en komparativ studie av historieundervisning vid amerikanska och svenska lärosäten. Skillnaderna till trots märks vissa gemensamma drag såsom att styrmekanismerna har blivit allt fler, vilket har inneburit att den enskilde läraren har fått allt mindre att säga till om, bland annat till följd av en marknadsanpassning av högre utbildning med fokus på mätbarhet och utvärderingar. Samtidig
Investigating the chemical homogeneity of stars born from the same molecular cloud at virtually the same time is very important for our understanding of the chemical enrichment of the interstellar medium and with it the chemical evolution of the Galaxy. One major cause of inhomogeneities in the abundances of open clusters is stellar evolution of the cluster members. In this work, we investigate va
This paper focuses on entrepreneurship by academic leaders. With the use of patents, inventions, and spin-offs to measure commercialization, and directors, research group leaders, and business owners as academic leaders, results, using a sample of more than 2,500 German researchers, show differences across academic leaders and commercialization. Findings for spin-offs are different from those for
Begonia mariachristinae Wahlsteen, a new endemic species from Kachin, northern Myanmar, is described and illustrated. The new species is characterised by its combination of four perianth segments in the female flower, two ovary wings, two locules, two styles and a dioecious breeding system.
The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify novel risk loci and likely causal genes, we performed a transcriptome-wide association study evaluating associations of genetically predicted gene expression with breast cancer
