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A guide in the darkness; A system shedding light on mRNA pseudouridylation by PUS7 Proteins, the building blocks of life, are produced from messenger RNA (mRNA). mRNA is built by four ribonucleotides, namely adenine (A), guanine (G), cytosine (C) and uridine (U). Interestingly, RNA includes also chemically modified versions of the above nucleotides affecting many physiological processes. The most

Type 2 diabetes is a growing health problem. 537 million people had diabetes in 2021 and the number is continuously increasing. Our group previously showed that the isoforms of the complement inhibitor CD59, named IRIS-1 and IRIS-2 (Isoforms Rescuing Insulin Secretion 1 and 2) are localized in the cytoplasm of pancreatic ß-cells, where they are needed for insulin secretion. A downregulation in the

Decoding Colors: How mutations in barley genes affect pigmentation Plants are an incredibly diverse group of organisms that share one crucial component: the presence of a green pigment called chlorophyll. Chlorophyll plays a pivotal role in capturing light energy and facilitating the process of photosynthesis, which converts this light energy into chemical energy. The green appearance of plants i

Syftet med uppsatsen är att undersöka hur tolv svenska skönlitterära förlag tänker kring att använda AI (artificiell intelligens) inom sin verksamhet, vilka hinder som kan finnas, samt om åsikterna kring AI är kopplade till synen på litterärt värde. Frågeställningarna som undersökningen utgår från fokuserar på hur förlagsanställda ställer sig till den potentiella användningen av AI i förlagsarbete

Klimatförändringar utgör ett stort hot mot mänskligheten. Samtidigt som den vetenskapliga kunskapen om problemen aldrig har varit större minskar inte utsläppen. Expertgruppen IPCC är en särskilt spännande aktör i sammanhanget och har till uppdrag att ge världens ledare kunskap om klimatfrågan. Men hur ser egentligen IPCC på klimatfrågan och hur menar de att våra klimatproblem kan lösas? Syftet m

HOW WILL SOIL BACTERIA REACT TO RISING TEMPERATURES? A significant amount of carbon is stored in soil, where microbes play a crucial role in determining how much carbon gets fixed and how much is released as CO2 into the atmosphere. This depends on the balance between microbial growth, which fixes carbon in soils, and in contrast on respiration which leads to the release of CO2. Approximately 50%

Reinforcement learning is one of the three main paradigms in machine learning, which is increasingly used as a method to approach scientific problems. In this thesis, we introduce and use reinforcement learning to find the optimal parameters of a numerical solver. We first motivate that solving the linear systems can be done by solving initial value problems. These initial values problems can the

Forskningsfråga: Hur presenteras reklamfilmer av ett nytt varumärke för att bygga en stark och värdefull varumärkesidentitet? Syftet: Syftet med studien är att urskilja vad det är i Polestars reklamfilmer som skapar dess styrka i varumärkesidentiteten och hur reklamfilmerna porträtterar varumärkets identitet och personlighet. Denna studie syftar till att bidra med insikt och kunskap hur varumärken

This thesis will be an attempt to look beyond this relatively new conceptualisation of CRSV committed in the context of terrorism, so called ‘sexual terrorism’, to determine what are its implications for the development of the WPS agenda. Answering the research question ‘What are the consequences of the increased linking of CT and WPS, in particularly with regards to the consideration of sexual te

IKEA is a Swedish company that has been the largest retailer of furniture for the past fifteen years. Selling orders worth EUR 44.6 billion in 2022, IKEA has to meet great logistic needs in order to maintain a functioning business. In the current IKEA landscape teams that consume order data have to listen to multiple sources and compare the data they receive to get specific information from an ord

This project is about designing outerwear for equestrians. Jackets used in stables are often just like other jackets, and not optimized for the context. Being around horses includes needs, safety risks and movements that are irrelevant in most other situations. The product is a garment design that is adapted to the objects and activities that equestrians face on a daily basis. Integrated soft cove

The situation for the environment is in many ways dire. However, amidst all the negative environmental developments it is easy to neglect the successes that have actually happened. With the aim of better understanding what factors facilitated such a success this thesis analyses one such case, namely emissions of dioxins and chlorinated waste from the pulp and paper industry in Sweden. Dioxins were

Switzerland's current food system is unsustainable and responsible for 25% of the country's environmental footprint. Half of the greenhouse gas emissions from the Swiss food system are caused by meat and dairy consumption. Reducing Switzerland's GHG emissions from the food system requires an orchestrated approach, targeting amended consumption and production patterns. A primary change

In an era of globalization, where decision-making transcends national boundaries, it is crucial to recognize the importance of individual participation in shaping the international legal sphere. This recognition becomes even more critical in the 21st century, as we are faced with the need to respond to global challenges and emergencies that demand the collaboration of diverse actors. The inclusive

Populärvetenskaplig sammanfattning Energi- och klimatberäkningar kopplat till olika byggmaterial och värmeförluster som uppkommer i anslutningar där byggdelar möts. Klimat och miljö har under de senaste åren blivit alltmer uppmärksammat och äntligen följer Boverket med! Med den nya lagen som trädde i kraft under 2021, om att undersöka klimatpåverkan hos nybyggda hus har man satt byggbranschens mConsidering the current energy and climate crisis, it is important to examine how the impact on these can be managed and reduced within the building sector. One of the objectives of this study is to analyze the impact of several typical thermal bridges for a single-family house on the energy use and show how these vary depending on the choice of framing system. The framing systems studied are CLT,

Surface soil moisture (SM) is a crucial variable representing the water content in soil at the topmost soil layer. Accurate data of SM are essential for many applications such as drought monitoring, vegetation modelling, weather forecasting, and agriculture management. Over the past decades, microwave remote sensing has been employed to estimate SM at large scales, with the Sentinel-1 satellite mi

This thesis explores the growing interest in sustainability in the cosmetic industry, particularly focusing on the rise of natural cosmetic products. The study adopts an explanatory sequential mixed methods design, incorporating quantitative analysis of patent data from the European Patent Office between 2000 and 2022, as well as qualitative insights from expert interviews. The findings indicate a

Österskans är ett projekt som undersöker platsen med samma namn i Halmstad. Det gick från att på slutet av 1900-talet ha varit ett resecentrum till att kommunen 2017 utlyser en intresseanmälan till en markanvisningstävling för ett hotell med saluhall och restaurang. White Arkitekter vann, men publik uppmärksamhet och medieuppbåd gjorde att det blev fördröjningar innan det 2022 blev en folkomröstni

The objective of this thesis is to develop a methodology for evaluating the performance of material models during biaxial loads. This is done by executing identical punch tests, one in a simulation and one in a physical experiment, and then comparing the results from the two. The material model that is to be evaluated is used in the simulation and a specimen of the corresponding material in the ph