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Patients with Wilms tumor (WT) in general have excellent survival, but the prognosis of patients belonging to the subgroup of WT with diffuse anaplasia (DA) is poor due to frequent resistance to chemotherapy. We hypothesized that DA WT cells might undergo changes, such as acquiring a persistent tolerance to DNA damage and copy number aberrations (CNAs), which could eventually lead to their resista
Background: Tuberculosis (TB) disease has been associated with pregnancy complications. However, the potential impact of TB infection (TBI) on pregnancy outcome is unknown. To investigate this, we conducted a register-based study in immigrant women screened with QuantiFERON assays for TBI in antenatal care in Sweden. Methods: Women with history of immigration from TB-endemic countries were eligibl
Background: In Sweden, information on seroprevalence of tick-borne encephalitis virus (TBEV) in the population, including vaccination coverage and infection, is scattered. This is largely due to the absence of a national tick-borne encephalitis (TBE) vaccination registry, scarcity of previous serological studies and use of serological methods not distinguishing between antibodies induced by vaccin
Background: There is little agreement on clinically useful criteria for identifying real-world responders to biologic treatments for asthma. Objective: To investigate the impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in adults with severe asthma. Methods: This was a longitudinal, cohort study across 22 countries participating in the International Sever
Cooperative transport allows for the transportation of items too large for the capacity of a single individual. Beyond humans, it is regularly employed by ants and social spiders where two or more individuals, with more or less coordinated movements, transport food to a known destination. In contrast to this, pairs of male and female dung beetles successfully transport brood balls to a location un
Leveraging the potential of machine learning and recognizing the broad applications of binary classification, it becomes essential to develop platforms that are not only powerful but also transparent, interpretable, and user friendly. We introduce alphaML, a user-friendly platform that provides clear, legible, explainable, transparent, and elucidative (CLETE) binary classification models with comp
Diabetic muscle atrophy is an inflammation-related complication of type-2 diabetes mellitus (T2DM). Even though regular exercise prevents further deterioration of atrophic status, there is no effective mediator available for treatment and the underlying cellular mechanisms are less explored. In this study, we investigated the therapeutic potential of MCC950, a specific, small-molecule inhibitor of
Poor self-rated health (SRH) is associated with incident arterial cardiovascular disease in both sexes. Studies on the association between SRH and incident venous thromboembolism (VTE) show divergent results in women and no association in men. This study focuses on the association between change in SRH and incident VTE in a cohort of 11,558 men and 6682 women who underwent a baseline examination a
Background: Creativity is a multifaceted, complex, activity, and as such is an overarching function of the brain rather than being confined to a specific structure or region. Alzheimer's disease effects several cognitive domains involved in the creative process of producing art. Objective: We analyze the art of a well-known Swedish visual artist who suffered from Alzheimer's disease to determine i
Single bicycle crashes, i.e., falls and impacts not involving a collision with another road user, are a significantly underestimated road safety problem. The motions and behaviours of falling people, or fall kinematics, are often investigated in the injury biomechanics research field. Understanding the mechanics of a fall can help researchers develop better protective gear and safety measures to r
Abstract in GermanIn Die Soziallehren der christlichen Kirchen und Gruppen stellt Ernst Troeltsch ein riesiges Forschungsprogramm auf, das an der Schnittstelle von Soziologie und Theologie liegt. In Auseinandersetzung mit materialistischen und idealistischen Ansätzen erforscht er das Christentum als „Praxis“, in der theologische Ideale auf soziologische Realitäten und soziologische Realitäten auf
Abstract in GermanSecularization: An Analysis at Three Levels lässt sich als Synthese von Karel Dobbelaeres Arbeiten lesen. Er definiert Säkularisierung darin als einen Prozess, durch den Religion in Gesellschaften der Moderne mehr und mehr an Bedeutung verliert. Der Grundgedanke Dobbelaeres lautet dabei, dass Säkularisierung nach makro-, meso- und mikrosoziologischer Ebene zu differenzieren ist.
Gate-tunable Josephson junctions are interesting for quantum technology applications, such as gatemon qubits and topological Majorana-based qubits. Furthermore, high-frequency compatible geometries can be utilized for implementing electrically pumped parametric amplifiers. In this paper, we combine processing, measurements, and modeling of near-surface InGaAs Josephson field-effect transistors in
Bei Migration geht es um die Ein- und Auswanderung von Menschen. Sie ist ein Dauerphänomen der Menschheitsgeschichte. Gegenwärtig wird Migration aber als Krise gedeutet. Die Migrationsethik steht im Spannungsfeld kommunitaristischer und kosmopolitischer Gerechtigkeitsvorstellungen. Die Frage nach der Geltung von Rechten, die unter Bezug auf vielfältige Fluchtursachen ausgehandelt wird, ist für die
The far right is on the rise across Europe. In Germany, the political party Alternative für Deutschland (AfD) has had striking success in several elections, establishing itself in parliaments across the country. Although Christianity comes up in the programmes and the politics of this party, theologians in Germany have been hesitant to engage the rise of the far right. In this review, I present tw
“Tin-oxo cage” organometallic compounds are considered as photoresists for extreme ultraviolet (EUV) photolithography. To gain insight into their electronic structure and reactivity to ionizing radiation, we trapped bare gas-phase n-butyltin-oxo cage dications [(BuSn)12O14(OH)6]2+ in an ion trap and investigated their fragmentation upon soft X-ray photoabsorption by means of mass spectrometry. In
