Use of DISCO optical tissue clearing technologies for studying glymphatic function and CSF efflux in a mouse model
What transparent brains teach us about how our brain cleans itself? The brain has a high rate of metabolic activity but paradoxically it lacks lymphatic vessels. Instead, clearance of waste products is taken care of by the glial-lymphatic (glymphatic) system. The Glymphatic system works by circulating cerebrospinal fluid through and out of the brain. We have developed a new way to study the glymp