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Background: Asthma, a prevalent chronic lung disease, affecting millions worldwide, is characterised by airway inflammation and increased smooth muscle mass and constriction, leading to the narrowing of the airway walls. Recent biologics have emerged as promising treatments for asthma. This study focuses on Tezepelumab, a monoclonal antibody targeting TSLP, which has been shown to improve airway h
Small cell lung cancer (SCLC) is a highly aggressive form of cancer, characterized by a particularly poor prognosis. Subsequently, it has a very low five-year survival rate of only 6%. At the clinic, patients are either diagnosed at advanced stages where care is more palliative and with few therapeutic options or, when diagnosed at earlier stages, respond very positively to first-line treatments b
Streptococcus pyogenes, or group A streptococci (GAS) is a well known agent of pharyngitis. The same goes for the closely related S. dysgalactiae subspecies equisimilis (SDSE). Recent data indicates that a third pathogen called Fusobacterium necrophorum, with similarly severe complications to GAS is the second most common pathogen in pharyngitis. These infections cause the greatest damage in low
DNA Encoded Library (DEL) screening has emerged as a transformative technology in pharmaceutical research, enabling the high-throughput screening of billions of compounds. While DEL screening has been successful in identifying small molecule ligands for various protein targets, challenges remain in targeting specific classes of proteins, such as membrane proteins, which are challenging to purify a
Body alignment is a spontaneous response documented in a variety of animals, including songbirds, however the biological significance of this behavior remains elusive for most taxa. Migratory songbirds rely on an endogenous migration program to migrate, and extract navigational information from celestial and magnetic cues. To investigate the body alignment behavior, the resting position of individ
Understanding what influences reproduction within populations is important to assess what changes are happening, especially for species with declining populations. In this study, I focus on a large seabird, the great skua (Stercorarius skua) which have been shown to have declining population trends in most of their breeding range in recent years. Skuas are long-lived species with delayed sexual ma
As society's capacity for data collection increases, the need for automated processing techniques becomes increasingly relevant. One way to evaluate data is to find the subset which does not conform to normal behaviour, i.e., anomalies. If the data is in the form of trajectories in some space, the algorithms used to find these are trajectory anomaly detection algorithms. In this paper, the tra
This thesis investigates buyer preferences in the procurement of Internationally Transferred Mitigation Outcomes (ITMOs) under Article 6.2 of the Paris Agreement, which facilitates international cooperation through carbon markets. As ITMO markets are still in the early stages of development, uncertainties regarding regulatory frameworks, environmental integrity, and procurement strategies have eme
Nearly all multicellular organisms reproduce sexually, whereas asexual reproduction is predominant in unicellular species. However, it is unclear why we see such a tight co-occurrence between multicellularity and sex. Here, we investigate the effect sexual reproduction has on the evolution of multicellularity in the green algae, Chlamydomonas reinhardtii, specifically on the variation and novel ph
Since we as architects have an influence on people‘s everyday routines in their homes, it is important to understand the most natural human needs in order to create spaces for a healthy and joyful life, which are strongly connected to the environment. The human body is a complex organism which is strongly influenced by its immediate surroundings, whilst responding with circadian rhythms to the eve
This thesis examines how girls are portrayed in Swedish adolescent literature from the 1940s and 1950s – Ingen tror på Britt (1947), Den svarta fläcken (1949), Inga och livet (1951), Ingen lugn stund hos Oskarssons (1953) and lastly, Flickan från landet: berättelse för flickor (1954). By taking a new historical approach a historical contextualisation has been done of the works by interpreting hist
The issue of dignity in the context of asylum seekers and their care has been widely discussed from various perspectives. As the rate of asylum-seeking increases, so too does the politics surrounding bare minimum standards. In the process of seeking asylum, individuals are increasingly forced to trade-off access to other rights. This study investigates the normative and human rights gaps in asylum
Bakgrund: Fler individer väljer att få dö i sitt eget hem. Syftet med palliativ vård är att främja livskvalitet och lindra lidande för individer med obotlig sjukdom. Sjuksköterskan har ett övergripande omvårdnadsansvar inom den palliativa vården och behöver kunna vara självständig och kunna fatta egna beslut. Det ställer höga krav på sjuksköterskan som arbetar i denna komplexa arbetsmiljö. Sjukskö
In 2018, the European daylight standard EN 17037:2018 was published to encourage designers and developers to assess and provide sufficient daylight in buildings. However, the revision process by the European Committee for Standardisation identified that the recommendations for daylight provision are often challenging to achieve; therefore, the technical committee for the daylight working group, th
Abstract: This thesis is an attempt to evaluate the pre-Christian and Christian and cult-place continuity question. This is done by investigating intervisibility between Christian Churches and pre-Christian grave monuments within the province of Halland, Sweden. This analysis was done via large statistical GIS databases of which viewshed analysis was applied to, which in turn was then interpreted
