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Introduction: Lymph node metastases are a key prognostic factor in prostate cancer (PCa), but detecting lymph node lesions from PET/CT images is a subjective process resulting in inter-reader variability. Artificial intelligence (AI)-based methods can provide an objective image analysis. We aimed at developing and validating an AI-based tool for detection of lymph node lesions. Methods: A group of
This study experimentally investigates the radiation heat flux distribution received on the floor due to fire plume impinging upon an inclined ceiling, which has not been quantified previously. The radiation heat fluxes were measured on the floor for 160 experimental conditions, involving various fire source heat release rates, source-ceiling heights, angles of ceiling inclination and dimensions (
Background: To understand how the neuronal circuits in the brain process information there is a need for novelneuro-electronic interfaces that can interact chronically with brain tissue with minimal disturbance of thephysiological conditions in the tissue, in awake and freely moving animals. For this, there is a need for implantableneuro-electronic interfaces that are mechanically compliant with t
Background: Interatrial block (IAB) and abnormal P-wave terminal force in lead V1 (PTFV1) are electrocardiographic (ECG) abnormalities that have been shown to be associated with new-onset atrial fibrillation (AF) and death. However, their prognostic importance has not been proven in cardiac resynchronization therapy (CRT) recipients. Objective: To assess if IAB and abnormal PTFV1 are associated wi
The sharing of indoor space can improve space and energy efficiency. The drivers and barriers to space-sharing initiatives are investigated from the perspectives of building users and building sector practitioners, based on interviews and a workshop. The role of energy performance metrics in promoting space efficiency is further analysed through a literature review. From the users’ perspective, sp
Housing preferences and housing decision-making in later life are critical aspects of aging in place, which is a public health priority in many Western countries. However, few studies have examined the economic, social, and health factors that guide older adults’ preferences and decisions about where to live, and even less so among older adults with low income or disabilities who may face greater
Building databases are important assets when estimating and planning for national energy savings fromenergy retrofitting. However, databases often lack information on building characteristics needed to determine the feasibility of specific energy conservation measures. In this paper, machine learning methods are used to enrich the Swedish database of Energy Performance Certificates with building c
BACKGROUND: Children experience a higher risk of psychiatric problems when their parents are diagnosed with cancer. However, the psychological effect among offspring who are born after parental cancer diagnosed in childhood or adolescence is unknown. We aimed to investigate the risk of psychiatric disorders in children of survivors with childhood or adolescent central nervous system (CNS) tumors.M
BACKGROUND: Expensive cancer treatment calls for alternative ways such as drug repurposing to develop effective drugs. The aim of this study was to analyse the effect of post-diagnostic use of cholera vaccine on survival outcome in breast cancer patients.METHODS: Cancer diagnosis and cholera vaccination were obtained by linkage of several Swedish national registries. One vaccinated patient was mat
BACKGROUND: Drug repurposing, the application of known drugs and compounds with a non-oncology primary purpose, might be an attractive strategy to offer more effective treatment options to patients with cancer at a low cost and reduced time.METHODS: This review described a total of 10 kinds of non-oncological drugs from more than 100 mechanical studies as well as evidence from population-based stu
Risk assessment studies addressing effects of agrochemicals on bumblebees frequently use microcolonies. These are queenless colonies consisting of workers only in which typically one worker will lay unfertilized male-destined eggs. In the first tier of risk assessment for bees, short-term laboratory experiments (e.g. microcolonies) are used, the results of which will determine whether higher tier
Background: In Sweden, cobalt chloride 0.5% has been included in the baseline series since the mid-1980s. A recent study from Stockholm showed that cobalt chloride 1% petrolatum (pet.) was more suitable than 0.5%. Cobalt chloride at 1.0% has been patch tested for decades in many European countries and around the world. Objectives: To study the suitability of patch testing to cobalt 1.0% vs 0.5% an
Prosodic prominence is a multimodal phenomenon where pitch accents are frequently aligned with visible movements by the hands, head, or eyebrows. However, little is known about how such movements function as visible prominence cues in multimodal speech perception with most previous studies being restricted to experimental settings. In this study, we are piloting the acquisition of multimodal promi
Operating lignocellulosic fermentation processes to produce fuels and chemicals is challenging due to the inherent complexity and variability of the fermentation media. Real-time monitoring is necessary to compensate for these challenges, but the traditional process monitoring methods fail to deliver actionable information that can be used to implement advanced control strategies. In this study, a
In a recent communication on carbon isotope chemostratigraphy of the uppermost Cambrian strata, it was claimed that the Top of Cambrian Excursion (TOCE) is (1) an undocumented negative δ13Ccarb excursion; (2) ambiguously defined; (3) deliberately fictitious or, in the authors’ words, a ‘nihilartikel’; and (4) not synonymous with the Hellnmaria–Red Tops Boundary (HERB) Event. As the authors who hav
OBJECTIVE: The examination of the genotoxic, cytostatic and cytotoxic effects of smoking during pregnancy.METHOD: Lymphocyte cultures of peripheral blood were received from 20 women who smoked during pregnancy as well as umbilical cord blood of their newborns. Fluorescence Plus Giemsa staining technique was used in order to perform cytogenetic analyses for three indices, Sister Chromatid Exchanges
BACKGROUND: The objective of this study was to evaluate the feasibility and midterm outcomes of iliac branch devices (IBDs) to preserve the internal iliac artery perfusion in emergent endovascular repair of ruptured aorto-iliac aneurysms.METHODS: Between December 2012 and July 2017, a total of 8 IBDs were implanted in 6 patients (the median age 65 years; all men) in a single tertiary referral cent
Spurred by availability of automatic segmentation software, in vivo MRI investigations of human hippocampal subfield volumes have proliferated in the recent years. However, a majority of these studies apply automatic segmentation to MRI scans with approximately 1 × 1 × 1 mm3 resolution, a resolution at which the internal structure of the hippocampus can rarely be visualized. Many of these studies
