The minimum energy conformations of the four sterically reasonable SLex and SLea lactones were calculated using the molecular mechanics force-field MM2(91). The tetrasaccharide lactone involving the 3- and 2-position of the Gal moiety was found to be more stable than the 3,4-lactone both for SLex and SLea. © 1994.

A series of conformationally restricted 0-, C-, S-, and N-“furanosides” have been synthesized, where the number 3 and 4 carbons are part of a norbornane ring system. All the carbons of the tetrahydrofuran ring are kept in one plane by the rigid norbornane skeleton, permitting only the ring oxygen to move above or below the tetrahydrofuran ring plane. This causes the substituents on carbon 2 to occ

(Trimethylsilyl)ethyl 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranoside and (trimethylsilyl)ethyl 2,3,6-tri-O-acetyl-4-O-(2,3,6-tri-O-acetyl-4-O-[2-acetamido-4,6-di-O-ace tyl-2- deoxy-3-O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-beta-D- galactopyranosyl]-beta-D-galactopyranosyl)-beta-D-glucopyranoside have been transformed in high yield into the corresponding 1-O-beta-acyl saccharides by treat

This article proposes a dual-band, frequency- and polarization-selective surface. Multiple resonant modes are introduced using the U-shaped resonator with a ground via to achieve dual-band responses and polarization selectivity. Two symmetrically grounded U-shaped resonators are coupled through electrically coupled apertures in a common ground, resulting in a passband with two transmission zeros p

Epistemological contextualism states that propositions about knowledge, expressed in sentences like “S knows that P,” are context-sensitive. Schaffer (2005) examines whether one of Lewis’ (1996), Cohen’s (1988) and DeRose’s (1995) influential contextualist accounts is preferable to the others. According to Schaffer, Lewis’ theory of relevant alternatives succeeds as a linguistic basis for contextu

Energy transitions are at the top of global agendas in response to the growing challenges of climate change and international conflict, with the EU positioning itself as playing a pivotal role in addressing climate risks and sustainability imperatives. European energy transition policies identify ‘smart consumption’ as a key element of these efforts, which have previously been explored from a pred

Background Direct cell reprogramming is characterized by the use of defined factors to rewire the transcriptional and epigenetic network of one cell-type into one of a different lineage. We have recently identified the transcription factors PU.1, IRF8, and BAFT3 (PIB) as sufficient to induce a type 1 conventional dendritic cell (cDC1) fate in both somatic and cancer cells.1,2 cDC1 is a rare dendri

BACKGROUND: Segmenting the whole-body somatostatin receptor-expressing tumour volume (SRETVwb) on positron emission tomography/computed tomography (PET/CT) images is highly time-consuming but has shown value as an independent prognostic factor for survival. An automatic method to measure SRETVwb could improve disease status assessment and provide a tool for prognostication. This study aimed to dev