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Background: Rare variants of the triggering receptor expressed on myeloid cell 2 (TREM2) gene are strong risk factors for Alzheimer’s disease (AD), and drugs targeting the TREM2 protein are being developed. However, it is unknown what the effect of TREM2 variants is on the AD phenotype. Methods: Here we studied a full range of clinical and biomarker measures in a large cohort of TREM2 variant carr
Patients with systemic lupus erythematosus (SLE) face an approximately 30 % risk of thrombosis post-diagnosis. However, there remains significant knowledge gaps regarding causative mechanisms, and there is a lack of specific antithrombotic guidelines. This systematic review aims to examine the existing literature regarding the mechanisms contributing to thrombosis risk in SLE, focusing on five pre
Intrauterine fetal programming determines cardiorenal interaction later in life. We hypothesize that early life factors affect adult glomerular filtration rate and mean arterial pressure (MAP) directly or by interacting with postnatal growth trajectories. The population-based LifeGene study (Sweden) randomly recruited individuals aged 18 to 43 years (n = 12 167). They filled in a web-questionnaire
Catalytic studies traditionally rely on steady-state conditions resulting in time-averaged datasets that do not differentiate between active and spectator species. This limitation can cause misinterpretations of catalytic function, as the signal of short-lived intermediates responsible for producing desired reaction products is often masked by more intense spectator species. Time-resolved ambient
The genetic contributions to early onset heart failure (HF) are incompletely understood. Genetic testing in advanced HF patients undergoing heart transplantation (HTx) may yield clinical benefits, but data is limited. We performed deep-coverage whole genome sequencing (WGS) in 102 Swedish HTx recipients. Gene lists were compiled through a systematic literature review. Variants were prioritized for
The paper deals with the effects that robot adoption in a country may generate in other trade-related countries. We concentrate on the Top 5 European economies as robot adopters over the period from 1995 to 2018 (Italy, Germany, France, Spain, UK) by testing whether robot adoption affects employment dynamics also beyond borders. To reach this goal we develop a composite indicator that captures bot
Induced pluripotent stem cells (iPSCs) have significant potential for disease modeling and cell therapies. However, their wide-spread application has faced challenges, including batch-to-batch variabilities, and notable distinctions when compared to embryonic stem cells (ESCs). Some of these disparities can stem from using undefined culture conditions and the reprogramming procedure, however, the
Diplomonads are anaerobic, flagellated protists, being part of the Metamonada group of Eukaryotes. Diplomonads either live as endobionts (parasites and commensals) of animals or free-living in low-oxygen environments. Genomic information is available for parasitic diplomonads like Giardia intestinalis and Spironucleus salmonicida, while little is known about the genomic arrangements of free-living
Climate change and the resulting warming caused by human activities, such as releasing greenhouse gases (GHG), notably carbon dioxide (CO2), are paramount concerns in the contemporary era. Therefore, it is essential to understand spatial and temporal variations of atmospheric carbon dioxide concentration (XCO2) on national and international scales and the role of controlling variables. This resear
Marine coatings used on merchant ships have recently emerged as a source of microplastics in marine environments. Marine coatings encompass all paints and coatings applied to various parts of a ship, primarily for anti-corrosion, antifouling anti-skid, heat-resistance, and cosmetic enhancement. However, marine coatings on merchant ships have evaded classification and were not included in the micro
Title: Women experiencing the second stage of labour for the first time: a qualitative free-text analysis within the Oneplus trial. Background: The second stage of labour is the time from full cervical dilation to the birth of the baby. The risks to the woman and the baby are increased during this stage, leading to intensified midwifery care. A positive birth experience is a significant goal of in
Many preschoolers in Sweden have other family languages than Swedish. Sign-supported speech (SSS) is often used to support children's second language development and participation in interaction. The aim of the present paper is to study how preschool teachers use SSS in interaction with multilingual children, and children's way of participation in such interaction. The study was conducted in three
Medical image segmentation is a critical component in a wide range of clinical applications, enabling the identification and delineation of anatomical structures. This study focuses on segmentation of anatomical structures for 3D printing, virtual surgery planning, and advanced visualization such as virtual or augmented reality. Manual segmentation methods are labor-intensive and can be subjective
Climate change poses a significant global challenge, profoundly affecting species distribution. In recent years, research focusing on the impacts of climate change on freshwater taxa has been relatively limited compared to studies on terrestrial taxa. This study seeks to identify hotspots and occurrences of all Carasobarbus freshwater fish species while also predicting the potential implications o
JavaDL ArtifactJavaDL is a language and toolchain for analyzing Java at the source level. JavaDL is based on MetaDL, a variant of Datalog that adds syntactic pattern matching, here specialized to pattern matching on Java.
Artificial intelligence (AI) is set to disrupt the way businesses and civil society operate, but the large energy usage for training and running AI compute models remains a pressing concern in terms of its sustainability. Analog in-memory computing (AIMC) hardware based on memristor devices is a promising route to significant energy-savings. Among the various memristor technologies, ferroelectric
The Natural Resources Conservation Service Curve Number method (NRCS-CN) is the most widely used approach to estimate runoff from rainfall events. However, some uncertainties in the method remain linked to the value of the standard initial abstraction ratio (λ) and discrepancies between computed and standard tabulated Curve Number (CN) values. Here, we compute CN values and investigate the effects
