Filetype
The chaperone DNAJB6 inhibits aggregation of several amyloid proteins, such as α-synuclein and huntingtin, which are involved in neurodegenerative diseases. Here, we designed a cell-based assay to measure DNAJB6 dimerization in HEK293 cells by fluorescent resonance energy transfer (FRET), as previous studies suggest that the activity of DNAJB6 is dependent on dimerization. The HEK293 cells were en
Gliomas that express the mutated isoforms of isocitrate dehydrogenase 1/2 (IDH1/2) have better prognosis than wild-type (wt) IDH1/2 gliomas. However, how these mutant (mut) proteins affect the tumor microenvironment is still a pending question. Here, we describe that the transcription of microtubule-associated protein TAU (MAPT), a gene that has been classically associated with neurodegenerative d
Plants can evolve rapidly after pollinator changes, but the response of different floral traits to novel selection can vary. Floral morphology is often expected to show high integration to maintain pollination accuracy, while nectar traits can be more environmentally sensitive. The relative role of genetic correlations and phenotypic plasticity (PP) in floral evolution remains unclear, particularl
Heterotrophic marine microorganisms have the capability to degrade and metabolize laminarin, which is the most abundant source of energy and nutrients in the marine environment, via enzymes encoded by genes clustered in polysaccharide utilization loci (PULs). In this study, a PUL potentially responsible for laminarin utilization was identified in the genome of the marine bacterium Muricauda l
Stone funerary orbs with carved ornamentation, along with similarly decoratedstones, but in the form of slabs, are a distinctive yet underexplored category ofarchaeological objects from Late Iron Age Sweden. These carved stones areoriginally found in burial contexts from the Migration Period (c. 400–550 CE)and at times early Vendel Period (c. 550–800 CE). In later centuries, they areknown to have
Natural polymers are promising sustainable materials for diverse applications. Xylans, major components of hemicellulose, exhibit origin-dependent substitution patterns that determine their physicochemical properties. Targeted enzymatic modification of these substituents offers a mild and precise approach for tailoring the polymer's characteristics. Glucuronidases (EC 3.2.1.139) and xylan α-1,2-gl
Recension av Paul Lay (red.), Spioner i historien. Från antiken till vita duken.
Groundwater stored in alluvial fan aquifers represents a key water resource in semi-arid mountainous regions, yet groundwater recharge mechanisms and flow dynamics remain poorly understood, particularly in data-scarce regions experiencing increasing water demand and anthropogenic pressure. This study investigates groundwater recharge processes and flow patterns in three adjacent watersheds of the
A measurement of off-shell Higgs boson production is performed in the H * → WW channel. The measurement uses a proton–proton collision dataset with an integrated luminosity of 140 fb−1 collected at a centre-of-mass energy of 13 TeV by the ATLAS detector at the Large Hadron Collider. Final states in which both W bosons decay leptonically are targeted, and events are categorised based on the flavour
A search for exotic decays of the Higgs boson H into new scalar or pseudoscalar particles that subsequently decay into b-quarks is presented. The search considers ZH production with several decay scenarios for the Higgs boson; first to a pair of identical scalars, H → 2a → 4b, second to a pair of scalars with different masses (ma1 < ma2), either directly, H → a1a2 → 4b, or via a longer decay chain
A search for the dimuon decay of the Higgs boson is presented based on pp collision data recorded by ATLAS during Run 3 of the Large Hadron Collider, corresponding to an integrated luminosity of 165 fb-1 at √s = 13.6 TeV. To enhance the sensitivity, the results are combined with those from Run 2. An excess of events over the background is observed with a significance of 3.4σ (2.5σ expected). The b
BackgroundCystic fibrosis (CF) is a genetic disorder characterized by chronic airway inflammation and lung function decline. CF-related diabetes (CFRD) is the main extrapulmonary complication and it is tightly linked to an impaired lung function, but the underlying mechanisms behind these observations are incompletely understood. In the present study, we aimed to compare airway microbiome composit
BACKGROUND: Iron deficiency is the most common micronutrient deficiency worldwide, negatively affecting quality of life and health. Young women are at particularly high risk due to increased iron demands during growth, menstrual blood losses, and dietary habits. There are no official guidelines recommending screening for iron deficiency in healthy young women. This study aimed to develop a screeni
Measurements of integrated and differential cross-sections for W±Z production in proton-proton collisions are presented. The data collected by the ATLAS detector at the Large Hadron Collider from 2015 to 2018 at a centre-of-mass energy of s=13 TeV are used, corresponding to an integrated luminosity of 140 fb−1. The W±Z candidate events are reconstructed using leptonic decay modes of the gauge boso
Jet flavour tagging enables the identification of jets originating from heavy-flavour quarks in proton–proton collisions at the Large Hadron Collider, playing a critical role in its physics programmes. This paper presents GN2, a transformer-based flavour tagging algorithm deployed by the ATLAS Collaboration that represents a different methodology compared to previous approaches. Designed to classi
Background: Seafarers constitute a global workforce exposed to unique psychosocial, organisational, and environmental stressors. Despite growing attention to maritime wellbeing, empirical evidence on how these multi level determinants interact to shape mental and physical health remains limited. This thesis aims to identify key determinants of mental health, wellbeing, happiness, and self rated he
Countries have pledged commitment to the 2030 Sustainable Development Goal (SDGs) and the Paris Agreement to combat climate change. To maximize synergies between SDGs and climate actions (CAs), we evaluate the alignment of national commitment to SDGs and emissions reduction targets by comparing action plans embodied in Voluntary National Review (VNR) reports and the Nationally Determined Contribut
Hybrid ventilation systems have become increasingly attractive, because they are considered to provide good indoor air quality (IAQ) with low energy consumption. In this study, we evaluate the performance of a hybrid ventilation system (operating on both mechanical and natural ventilation mode) by monitoring the IAQ (e.g. temperature, humidity, CO2 levels) and the energy consumption of a multifami
In a microbial fuel cell (MFC), exoelectrogens, which transfer electrons to the electrode, have been regarded as a key factor for electricity generation. In this study, U-tube MFC and plating methods were used to isolate exoelectrogens from the anode of an MFC. Disparate microorganisms were identified depending on isolation methods, despite the use of an identical source. Denaturing gel gradient e
