The metabolism of pyruvate in the cell is abnormally regulated in several human diseases, such as type-II diabetes, cancer and neurodegenerative disorders, in which the human mitochondrial pyruvate carrier (HuMPC) sits at a pivotal point. It transports pyruvate across the inner mitochondrial membrane and consists of two proteins, MPC1 and MPC2, and is a potential drug target against these diseases

This article discusses the challenges associated with maintaining water quality, particularly the issue of eutrophication, and the importance of technology advancements for monitoring and managing water quality. The potential of machine learning is highlighted, along with the importance of affordable and effective water quality monitoring techniques. The study aims to identify factors contributing

Autonomins roll i vården är svårbegriplig och varken patient eller vårdgivare har en tydlig uppfattning av begreppet. Detta resulterar i att patienters rättigheter regelbundet överträds vilket förhindrar tillfrisknandet och riskerar att vidare skada patienter. Syftet med denna explorativa studie var att undersöka och analysera anmälares (patienter och anhöriga) upplevelser av kränkningar inom den The role of autonomy in healthcare is unclear, and neither patients nor healthcare providers have a clear understanding of the concept. This results inpatients' rights being violated regularly, which hinders recovery and risks further harming patients. The purpose of this exploratory study was to investigate and analyze the reporters’ (patients and relatives) experiences of violations within t

Background: The lithotomy position is one of the four most common positions during surgical procedures. This position is very vulnerable for the patient and can lead to several different types of complications. To ensure a safe positioning the preoperative assessment and preparations requires an OR nurse’s specialist competence. The aim: The aim was to examine if OR nurses’ years of experience aff

Climate-changed induced extreme events like heatwaves have become increasingly critical issues in urban India. Rapidly growing cities are vulnerable to adverse effects of heatwaves exacerbated by inequalities embedded in urbanisation. This study uses the case of Bengaluru, India to explore how residents of different socio-economic backgrounds experience heatwaves. Further explored are adaptation s

Denna uppsats intresserar sig för hur samtalet kring gröna vågen pågick mellan 1971-1973 där de mångfacetterade idéerna och begreppets politiska såväl som individuella dimension är av prioritet. Under hösten 1971 etablerade Tidningen Land gröna vågen för att namnge den rörelse som flyttade ut från städerna till landsbygden. Begreppet ficks stort genomslag med tidningens reportageserie i flera dela

The subject of this research was to conceptualize a Museum for the Future of Design in Copenhagen. Particularly, the museum collection focuses on experimental research in design, architecture, art, and engineering. An open flat brownfield towards the sea on Refshaleøen Island was chosen as the most suitable location for the Museum. Refshaleøen is a harbour and industrial area with a plethora of n

This paper aims to investigate the relationship between environmental performance and credit ratings on the Asian, European, and North American market in the context of the ESG framework over a period of ten years through 2013-2022. Through the usage of primarily POLS and POLS with a fixed year effect model, 242 firms across the different regions are studied on an aggregate level, in terms of bein

The objective of the project was to improve an existing prototype called AstroVR. AstroVR is an educational VR experience with the intent of teaching astronomy to middle grade students. The goal of the masters thesis was specifically to make the product more usable and increase its effectiveness as a teaching tool. The product was improved over multiple iterations. Each iteration contained a desig

Wildland-Urban Interface (WUI) fires pose a significant threat to public safety and property in areas where urban development encroaches upon natural landscapes. This thesis aims to investigate the effect of smoke from a WUI fire on the tenability conditions of a small village and to establish a worst-case-scenario trigger boundary around it as an improved basis for the WUI available safe egress t

The focus of this thesis is centered around the cemeteries in Stockholm city. As a form of arrangement and design of objects located on the land, the cemetery can be conceptualized as a landscape. Its distinct function, serving as a memorial space for the living and a final resting place for the deceased, adds layers of complexity. As such, the cemetery becomes a shared space for both the living a

Bakgrund: Stick- och skärskador är vanligt bland operationspersonal. I samband med en stick- och skärskada startar en process som kan bli långdragen i form av oro i väntan på resultat och i värsta fall livslång sjukdom. Att uppmärksamma stick- och skärskador, vanliga moment när det sker och i vilken grad skadorna rapporteras är viktigt för att ett förbättringsarbete ska kunna planeras och implemen

This paper proposes a new method for quantifying financial integration by adapting Adrian & Brunnermeier (2016)’s ΔCoVaR to conform with standard asset pricing literature (Lewellen & Nagel 2006, Cochrane 2009). We reconcile ΔCoVaR with standard microeconomic theory (Waller & Lewarne 1994) and test for causal relationships with respect to the contagion of US acute financial shocks to th

This thesis is a case study exploring opportunity spaces in path development for offshore wind power in Skåne, Sweden, from 2000 to March, 2023. By exploring interactions between policies and actors in the region, it contributes to path development literature with a more complex interpretation of agency in opportunity spaces for development. The thesis outlines how actors strategically adapt their

Within the context of the European Union Competition Law, a master's thesis entitled "Data as a Barrier to Entry and an Essential Facility: Law & Economics Analysis" conducts an in-depth investigation of the function that data plays in relation to competition law. The idea that data might be a valuable asset in the contemporary digital economy is presented in the very first part

The publishing landscape has undergone significant transformation in the last years facing and implementing open science policies, including principles for open access (OA). However, certain challenges have been identified in OA-publishing for different scientific fields, such as the humanities, depending on the norms and traditions for how to conduct research and how to publish. The topic of this

Bakgrund och problemområde: Antal patienter som söker till Sveriges akutmottagningar ökar stadigt varje år bortsett från minskningen under pandemin. Siffror visar att väntetiden till läkare ökar vilket försvårar Socialstyrelsens fyra timmars mål och ambitionen med en högre vårdkvalité. En stor del av patienterna som söker sig till akutmottagningen behöver inte träffa en läkare och studier från and

As the climate crisis becomes more severe, carbon capture and storage (CCS) is increasingly seen as a viable option to help mitigate climate change. However, one risk with regard to CCS is that it locks us into the use of carbon-based energy sources and industry, creating a carbon lock-in. Looking at the German-Norwegian partnership to store German CO2 in Norway and to provide hydrogen in return,

L'exposition des sociétés au changement climatique exige des villes qu'elles répondent de manière adéquate aux pressions environnementales croissantes tout en garantissant le bien-être des citoyens. La planification urbaine durable est un outil important à cet égard. Malmö est un pionnier du développement urbain durable salué au niveau international, mais critiqué pour ses déficits en mati