Filetype
Macrophages infiltrate solid tumors and either support survival or induce cancer cell death through phagocytosis or cytotoxicity. To uncover regulators of macrophage cytotoxicity towards cancer cells, we perform two co-culture CRISPR screens using CAR-macrophages targeting different tumor associated antigens. Both identify ATG9A as an important regulator of this cytotoxic activity. In vitro and in
Context: Anomaly detection is crucial for maintaining cloud-based software systems, as it enables early identification and resolution of unexpected failures. Given rapid and significant advances in the anomaly detection domain and the complexity of its industrial implementation, an overview of techniques that utilize real-world operational data is needed. Aim: This study aims to complement existin
The role of anyonic statistics stands as a cornerstone in the landscape of topological quantum techniques. While recent years have brought forth encouraging and persuasive strides in detecting anyons, a significant facet remains unexplored, especially in view of connecting anyonic physics to quantum information platforms—whether and how entanglement can be generated by anyonic braiding. Here, we d
Purpose: To assess the ability of corneal epithelial aberrations to discriminate forme fruste keratoconus (FFKC) and keratoconus (KC) from normal eyes. Methods: This prospective, case-control study enrolled 91 right eyes from 91 normal participants, 87 eyes with FFKC and 148 eyes with KC. Epithelial aberrations for the 6-mm pupil were measured using an anterior segment optical coherence tomography
This paper takes its point of departure in the planned, but later stopped, memorial over the Utöya massacre in Norway. The suggested memorial called Memory Wound was designed by Swedish artist Jonas Dahlberg and would in reality become two memorials, one at Utöya and one in Olso. Examining the debate that eventually led to the cancellation of the planned memorial project, the paper raises question
This paper address the role of music in relation to whathere is defined as cultural trauma. The text takes its starting point in Jeremy Eichler’s (2023) project on the music of remembrance, in which he shows how music bears witness to history and carries the memory of the past, using the cases of composers that lived through the 2nd WW and the Holocaust, the paper establishes acase of how music ma
Concertos for bass tuba from the mid-nineteenth century, recorded between January - July 2025 using a copy of a Moritz-Wieprecht bass tuba, the original tuba patented in Berlin in 1835.
There has been a growing interest in how workers in high-carbon industries are impacted by low-carbon transitions and how such transitions can be implemented in a way that is just. This study explores the socio-cultural dimensions of these processes, focusing on the role of identity in shaping workers’ perceptions of low-carbon transitions and their ability to navigate change. It does so through a
BACKGROUND: Reliable biomarkers for amyotrophic lateral sclerosis (ALS) are urgently needed due to diagnostic and prognostic challenges. This systematic review and meta-analysis aimed to synthesize recent evidence on the utility of blood and cerebrospinal fluid (CSF) biomarkers for ALS.METHODS: We systematically reviewed studies published from January 1, 2019 to March 25, 2025, that evaluated bloo
Based on more than thirty years' fieldwork, this book aims to increase the understanding of music played on elaborate wooden floats which form vital components in Japanese festivals with a religious dimension. The focus is on float-festivals in Aichi prefecture in central Japan; but wider perspectives, international as well as national, also come into play.Float-festivals date back several centuriThis book aims to increase the understanding of festival music in Japan. It is based on more than thirty years of fieldwork. Close study of one local festival in the town of Taketoyo is combined with a wider comparative analysis that covers most of the of the Aichi prefecture in central Japan. All these festivals are float-festivals. Charged with spiritual power, the floats serve as mobile shrines
Sweden’s art and music schools (SAMS), established in the 1940s, provideaffordable extra-curricular instrumental and singing teaching for everychild, regardless of their family’s financial situation. Tuition is heavilysubsidised, with families contributing only some 7% of the cost. WhileSAMS traditionally offer one-to-one instruction, a recent governmentalreport (2016) advocates for group teaching
Rare preleukemic hematopoietic stem cells (pHSC) harboring only the initiating mutations can be detected at the time of acute myeloid leukemia (AML) diagnosis. pHSCs are the origin of leukemia and a potential reservoir for relapse. Using primary human samples and gene editing to model isocitrate dehydrogenase 1 (IDH1) mutant pHSCs, we show epigenetic, transcriptional, and metabolic differences bet
This study explores how listeners use verb constructions to describe everyday sounds. It considers (i) how the verb constructions provide Gestalt to events in the form of activities, processes and states, and (ii) how the constructions correspond to different aspects of a soundscape (sound sources, acoustic properties, and listener reactions). We found that verb constructions primarily describe so
OBJECTIVES: Penicillin V (PcV) is considered the first-line treatment for community-acquired pneumonia in Scandinavian countries, although data supporting this recommendation are scarce. Thus, this study aimed to compare PcV and amoxicillin regarding the risk of treatment failures in children aged >5 years and adults treated for pneumonia in primary care.METHODS: In this retrospective study of hea
Background: The COVID-19 pandemic accelerated the use of telemedicine, specifically video consultations as they provide healthcare access in challenging situations where face-to-face encounters are not possible. Nevertheless, it remains largely unknown to what extent the organisation of general practice and national digital infrastructures have impacted the uptake and use of video consultations. O
Water resource recovery facilities face challenges with increasingly stringent effluent demands, complexity and demand for capacity increasing investments. Emerging technologies such as digital twins could alleviate these problems but require high frequency influent data. This work presents a method for utilising measurements in the primary clarifier effluent with a model of the processes between
Background: The ability of modern ultrasound machines to detect signs of enthesitis has increased, yet there is a lack of studies on patients with long-standing radiographic axial spondyloarthritis (r-axSpA). Hence, we aimed to investigate the prevalence and clinical significance of Doppler signals indicative of inflammation in peripheral entheses of patients with long-standing disease. Methods: P
Conventional diagnostic methods often involve long incubation times due to limited fluid mixing in confined spaces, despite offering high sensitivity. Therefore, acoustic streaming was employed to enhance microscale advection, thereby improving biomolecular interactions and reducing assay duration. The micromixing capability was demonstrated by dispersing methylene blue (MB) in deionized water and
Recent years has seen increasing interest in the concept of affordances in music performance research. Hereby, the agency of musical instruments is understood as defined by the perceived opportunities for action emerging through the sensorimotor relationship (i.e. the continuous interaction between musician and instrument). As such, it is an analytical perspective that highlights material and embo
