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Robustness is a prominent feature of most biological systems. Most previous related studies have been focused on homogeneous molecular networks. Here we propose a comprehensive framework for understanding how the interactions between genes, proteins and metabolites contribute to the determinants of robustness in a heterogeneous biological network. We integrate heterogeneous sources of data to cons

Background: Sarcopenia, resulting from loss of muscle mass and function, is highly prevalent in the ageing societies and is associated with risk of falls, frailty, loss of independence, and mortality. It is important to identify environmental risk factors, so that evidence-based interventions to prevent sarcopenia can be implemented at the population level. This study aimed to examine the potentia

Background: The incidence and mortality of breast cancer in women is increasing worldwide. Breast cancer contains a subpopulation of cells known as cancer stem cells (CSCs). The CSCs are believed to be responsible for chemotherapeutic resistance and are also involved in tumor initiation, progression, evolution, and metastasis to distant sites. The present study aimed to investigate the anti-CSC po

Radionuclide molecular imaging of cancer-specific targets is a promising method to identify patients for targeted antibody therapy. Radiolabeled full-length antibodies however suffer from slow clearance, resulting in high background radiation. To overcome this problem, a pretargeting system based on complementary peptide nucleic acid (PNA) probes has been investigated. The pretargeting relies on s

Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associat

The problem of equivalence in terms of multistability properties between gene regulatory network models of different dimensionality has been recently addressed by Schittler et al.(2013). The authors in that work proposed construction rules for a high-dimensional dynamical system, when given a low-dimensional dynamical system and the high-dimensional network structure. However, the proof therein wa

When assessing patients presenting with weakness to the emergency department, the initial focus is on determining whether patients are suffering from conditions where prompt treatment decreases morbidity and mortality.  Diagnosis is based on an understanding of neuroanatomy and on pattern recognition.  A structured history, combined with selected physical examinations and bedside tests, are used t

We propose a variational autoencoder to perform improved pre-processing forclustering and anomaly detection on data with a given label. Anomalies howeverare not known or labeled. We call our method conditioned variationalautonencoder since it separates the latent space by conditioning on informationwithin the data. The method fits one prior distribution to each class in thedataset, effectively exp

Critical infrastructure systems must be both robust and resilient in order to ensure the functioning of society. To improve the performance of such systems, we often use risk and vulnerability analysis to nd and address system weaknesses. A critical component of such analyses is the ability to accurately determine the negative consequences of various types of failures in the system. Numerous mathe

With high energy heavy ion collisions one tries to create a new forms of matter that is similar to the one present at the birth of our Universe. Recent development on flow pattern, initial energy-density and freeze-out temperature shows that most likely this new form of matter is in a deconfined state, has colored degrees of freedom and is more fluid-like than gas-like. In present paper we calcula

In this paper we study the Fokker-Planck operator with potential V (x), and analyze some kind of conditions imposed on the potential to ensure the validity of global hypoelliptic estimates (see Theorem 1.1). As a consequence, we obtain the compactness of resolvent of the Fokker-Planck operator if either the Witten Laplacian on 0-forms has a compact resolvent or some additional assumption on the be

In this paper, robust detection, tracking and geometry estimation methods are developed and combined into a system for estimating time-difference estimates, microphone localization and sound source movement. No assumptions on the 3D locations of the microphones and sound sources are made. The system is capable of tracking continuously moving sound sources in an reverberant environment. The multi-p

In this paper the sum of an orthogonal matrix and an outer product is studied, and a relation between the norms of the vectors forming the outer product and the singular values of the resulting matrix is presented. The main result may be found in Theorem 1.

In this paper we will discuss structure and motion problems for curved surfaces. These will be studied using the silhouettes or apparent contours in the images. The problem of determining camera motion from the apparent contours of curved three-dimensional surfaces, is studied. It will be shown how special points, called epipolar tangency points or frontier points, can be used to solve this proble

In this paper, we extend the notion of affine shape, introduced by Sparr, from finite point sets to curves. The extension makes it possible to reconstruct 3D-curves up to projective transformations, from a number of their 2D-projections. We also extend the bundle adjustment technique from point features to curves. The first step of the curve reconstruction algorithm is based on affine shape. It is

We review the recent progress in the theoretical description and experimental observation of multiple parton interactions. Subjects covered include experimental measurements of minimum bias interactions and of the underlying event, models of soft physics implemented in Monte Carlo generators, developments in the theoretical description of multiple parton interactions and phenomenological studies o