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Gene panel sequencing has become a common diagnostic tool for detecting somatically acquired mutations in myeloid neoplasms. However, many panels have restricted content, provide insufficient sensitivity levels, or lack clinically validated workflows. We here describe the development and validation of the Genomic Medicine Sweden myeloid gene panel (GMS-MGP), a capture-based 191 gene panel includin
While recent studies have heralded large cities as “innovation machines”, the majority of regional studies of innovation are based on patent indicators. In this paper, we compare regional patent and innovation counts in Sweden (1970-2014) and document the presence of a sizeable urban bias in patent indicators, which is primarily explained by higher patent filing propensity in urban areas. We also
This study builds on analyses of everyday professional practices to explore de-bordering and re-bordering processes in the field of gender-based violence (GBV). The concepts of de-bordering and re-bordering practices express the tensions arising from the conflictual roles taken on by civil society actors (CSAs) in their double vest of service delivery for the state and advocate for migrant women w
Microbial necromass is increasingly recognized as an important fast-cycling component of the long-term carbon present in soils. To better understand how fungi and bacteria individually contribute to the decomposition of fungal necromass, three particle sizes (>500, 250–500, and <250 μm) of Hyaloscypha bicolor necromass were incubated in laboratory microcosms inoculated with individual strains of t
Accurate and reliable estimation of actual evapotranspiration (AET) is essential for various hydrological studies, including drought prediction, water resource management, and the analysis of atmospheric–terrestrial carbon exchanges. Gridded AET products offer potential for application in ungauged areas, but their uncertainties may be significant, making it difficult to identify the best products
Rapid warming increases winter soil carbon dioxide (CO2) efflux in Arctic tundra ecosystems, which can significantly offset carbon (C) uptake during growing seasons and affect the overall annual C balance. In winter, the Arctic landscape is predominantly covered with snow, which is vital for regulating ecological processes. Nevertheless, the impact of snow redistribution on the spatial distributio
Corynebacterium is a skin commensal bacterium that can contaminate blood cultures. It is however also a rare cause of infective endocarditis (IE). Here we report a case of Corynebacterium kroppenstedtii aortic prosthesis IE in a 76-year-old man where only a single blood culture bottle was positive initially. C. kroppenstedtii is a very rare cause of IE, only reported two times previously. The diag
BACKGROUND: This study investigates the excess costs of dementia from healthcare, social care services, and prescription drugs 3 years before to 6 years after diagnosis. Further, sociodemographic cost differences are explored.METHODS: Using Swedish register data from 2013 to 2016 to compare individuals diagnosed with dementia (n = 15,339) with population controls, the excess formal care costs for
Methods for soil water conditions assessment are often highly localized or data demanding. In this study we propose a new scalable approach to assess soil water conditions. The main goal is to test whether the approach can be used to provide information about local conditions, without the need of extensive data sets. The approach utilizes a combination of normalized topography derived from the HAN
Enhancing forest drought resilience is important for preserving ecosystem services in the face of climate change, but operational management methods for boreal forests aiming to preserve ecosystem services under drought are still largely missing. This study explores the use of satellite remote sensing to monitor vegetation stress phases related to drought progression and to quantify both short- an
The European spruce bark beetle ( Ips typographus L.) is a biotic disturbance that devastates forest environmental services, and its activities are exacerbated due to climate change. Accordingly, researchers seek workflows using remote sensing imagery for bark beetle detection in the early stage of the attack, enabling proactive management. Most previous studies attempted to detect attacks with pi
Artikel om de danska judarnas flykt över Öresund hösten 1943 ur ett regionalt, huvudsakligen skånskt, perspektiv.
Galectin-8 contains two different carbohydrate recognition domains (CRDs). Selective inhibitors for at least one CRD are desirable for galectin-8 biology studies and potentially for pharmacological purposes. Structure-guided design led to the discovery of potent and selective glycomimetic-heterocycle hybrid ligands, with a 4-(p-bromophenyl)phthalazinone derivative displaying a 34 μM Kd for galecti
Arkivens mediala villkor reglerar alltid historikerns förståelse och tolkning av det förflutna; det gäller även audiovisuella arkiv – vilka dessutom har en specifik mediehistoria. Denna bok handlar om hur audiovisuella medier kom att bevaras i Sverige under en sextioårsperiod med fokus på en rad olika modaliteter: film, ljud, eter. Det rör sig om en institutionshistorik med mediala förtecken där f
Firefighters are exposed to harmful and toxic substances during firefighting activities (i.e. training, live firefighting and overhaul) in building fires. This paper studies the impact of ‘new’ and sustainable materials (‘green’ buildings) on firefighter’s exposures during firefighting interventions. Cross-laminated wood (CLT), recycled wood material (referred to as ‘RECOMA’ in this paper) and gl
This paper examines the reaction-to-fire behaviour of building materials containing phase change materials by predicting their fire classification according to the European reaction-to-fire classification system (Euroclasses). While various building materials containing PCMs exist today, their application in buildings has been somewhat limited due to the fire behaviour of these building materials.
BACKGROUND: Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory joint disease, that influences patients' health in different ways, including physical, social, emotional, and psychological aspects. The goal of rheumatology care is to achieve optimal health and personalised care and therefore, it is essential to understand what health means for patients in the early course of RA. The aim
