The production of biopharmaceuticals so far has been based on batch processes that are robust and well-known, but very inefficient and inflexible, causing the products to be very expensive and process development to be slow and costly. The production of biopharmaceuticals is thus changing towards integrated continuous biomanufacturing (ICB) in order to reduce costs and increase flexibility in a co

Previously, microRNA‐100 (miR‐100) and its putative mRNA target, insulin‐like growth factor receptor‐1 (IGF1R) were identified as differentially and inversely expressed in bovine longissimus dorsi (LD) muscles with divergent intramuscular fat (IMF) content by our group. While IGF1R signaling is implicated in myogenesis and muscle lipid metabolism, the underlying regulatory mechanisms are poorly un

Rapporten fokuserar på hur Covid-19 har påverkat olika samhällsviktiga verksamheter i Skåne. Verksamheterna har påverkats mycket, men det har inte uppstått allvarliga funktionsstörningar. Undantagen är Hälso- och sjukvård samt omsorg, och Transportsektorn där även funktionspåverkan förekommit I rapporten analyseras även hur förberedelser har skett och vilka lärdomar som kan dras av Covid-19.

Based on concepts from quantum thermodynamics, the two-level system coupled to a single electromagneticmode is analyzed. Focusing on the case of detuning, where the mode frequency does not match the transitionfrequency, effective energies are derived for the levels and the photon energy. It is shown that these should be usedfor energy exchange with fermionic and bosonic reservoirs in the steady st

When training a deep learning model, the dataset used is of great importance to make sure that the model learns relevant features of the data and that it will be able to generalize to new data. However, it is typically difficult to produce a dataset without some bias toward any specific feature. Deep learning models used in histopathology have a tendency to overfit to the stain appearance of the t

OBJECTIVES: To examine how maternal and sociodemographic factors determine continued care-seeking behaviour from pregnancy to postnatal period in Kenya and Uganda and to determine associated neonatal survival outcomes.DESIGN: A population-based analysis of cross-sectional data using multinomial and binary logistic regressions.SETTING: Countrywide, Kenya and Uganda.PARTICIPANTS: Most recent live bi

Explosive remnants from military activities imply a complex and costly risk to be dealt with in society. The problem involves different risks that are currently managed in isolation and by different stakeholders. For prioritization and ranking between all contaminated areas, a common risk picture needs to be presented and communicated to decision-makers. This chapter analyses the pros and cons of

A three-dimensional numerical fluid-structure interaction (FSI) framework is successfully carried out on mechanical behaviour of new vortex generators (VGs) – rectangular trapezoidal winglet (RTW), angle rectangular winglet (ARW), curved angle rectangular winglet (CARW) – in smooth wavy fin-and-elliptical tube (SWFET) heat exchanger using the ANSYS MFX Multi-field® solver. The purpose of the prese

Convective heat transfer of aviation kerosene at supercritical pressures in a vertical upward tube of diameter 1.8 mm was numerically studied using RNG k-ε turbulence model with enhanced wall treatment. The thermo-physical and transport properties of the China RP-3 kerosene at various temperatures were obtained by a 10-species surrogate and the NIST Supertrapp software. The grid independence was f

Avtalsvitets relation till skada och skadestånd har sedan lång tid disku­terats i svensk juridisk litteratur. Någon samsyn i dessa frågor finns emeller­tid inte. Men med tre nya fall från Högsta domstolen kan man angripa problemen på nytt. Artikeln är ett bidrag dels till hur vi bör definiera avtalsvitet för att reglera dess relation till skada, dels hur två fall från Högsta domstolen bör förstås

Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels2, heart disease remains the leading cause of death worldwide3. Genome-wideassociation studies (GWAS) of bloo

Introduction: Postoperative delirium is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). Compromised regulation of the cerebral circulation may be a predisposing factor for delirium. However, the potential relationship between cerebrovascular reserve capacity and delirium is unknown. The aim of this study was to investigate if impaired cerebrovascular reserve capacity

Understanding the molecular determinants that underpin the clinical heterogeneity of non-muscle-invasive bladder cancer (NMIBC) is essential for prognostication and therapy development. Stage T1 disease in particular presents a high risk of progression and requires improved understanding. We present a detailed multi-omics study containing gene expression, copy number, and mutational profiles that