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Dose-efficient multimodal microscopy of human tissue at a hard X-ray nanoprobe beamline

X-ray fluorescence microscopy performed at nanofocusing synchrotron beamlines produces quantitative elemental distribution maps at unprecedented resolution (down to a few tens of nanometres), at the expense of relatively long measuring times and high absorbed doses. In this work, a method was implemented in which fast low-dose in-line holography was used to produce quantitative electron density ma

The technological work of standing in

The narrative of the Western modernity is a story about technological progress where technology gradually has replaced humans in the world of work. Yet, the relationship between technology and humans is more complex than that. This is illustrated by Jeff Bezos’ idea of “Artificial Artificial Intelligence,” where humans are hired as stand-ins when automatized systems fail. Much has been said about The narrative of the Western modernity is a story about technological progress where technology gradually has replaced humans in the world of work. Yet, the relationship between technology and humans is more complex than that. This is illustrated by Jeff Bezos’ idea of “Artificial Artificial Intelligence,” where humans are hired as stand-ins when automatized systems fail. Much has been said about

The Meridian S02E00 : The Winter Solstice special episode

In this very special solstice episode of The Meridian Nic and Rebecca look back at some of the highlights of 2021. With the days growing ever longer here in the Northern Hemisphere they have rallied a troupe of PhD students to compete in the 2021 Astronomy Games! Nic is joined by Alvaro and Johan on his team and Rebecca has convinced Daniel and Madeleine to join her team. The Games were recorded i

The Meridian S02E01 : The James Webb Space Telescope & an unexpected boat ride

In this first episode of the second season Nic and Rebecca invite Ori Fox to the podcast to discuss the newly launched JWST. Ori is an instrument scientist at the pace Telescope Science Institute (STSI) working on the Mid-Infrared Instrument (MIRI) which is one of four instruments on the James Webb Space Telescope. In this second season of the Meridian we are also bringing you some field reporting

The Meridian S02E02 : Galactic archeology & ash on the mountain

In the second episode of the second season Nic and Rebecca invite Diane Feuillet to the microphone. Diane is a researcher here at Lund Observatory working on galactic archaeology using stellar abundances, ages and kinematics. In this second season of the Meridian we are also bringing you some field reporting from the Nordic Optical Telescope on La Palma, where a team of astronomers are trying to c

The Meridian S02E03 : Instrumentation & an Aussie encounter

In this third episode of the second season Nic and Rebeca chat about equality in science before inviting Nikolai Piskunov to the microphone. Nikolai is a professor at the Department of Physics and Astronomy at Uppsala University. He was visiting Lund Observatory to give a talk about high-resolution transit spectroscopy and graciously agreed to make an appearance on the podcast.This season we are a

The Meridian S02E04 : The European Southern Observatory & an eathquake on the mountain

The European Southern Observatory, or ESO, is celebrating 60 years of scientific achievements in the southern hemisphere. Sweden is one of the founding members of ESO, and several astronomers from Lund have been actively involved over the years. In the fourth episode of the second season our podcast hosts, Nic Borsato and Rebecca Forsberg, invite professor emeritus Dainis Dravins to the microphone

The Meridian S02E05 : New insights into Venus' past & an erupting volcano

Michael Way works at the NASA Goddard Institute for Space Studies where he is modeling planetary atmospheres, with a special interest for Venus and its history. He was visiting Lund Observatory to give a talk at the Källén Seminars for Young Astronomers recently, and we invited him onto the podcast to ask him if there is a chance that Venus has ever been habitable (Spoiler: the answer is 'yes'). I

The Meridian S02E06 : Nuclear fusion, fission & a chat with a telescope operator

Joining us on the Meridian today we have Colin Carlile, the former director of the Institut Laue-Langevin (ILL). He came to Sweden to head up the Swedish bid to locate the European Spallation Source here in Lund, and after formally retireing he did a master degree in astronomy here at Lund Observatory. In this second season of the Meridian we are also bringing you some field reporting from the Nor

The Meridian S02E07 : Ancient solar storms & observing reflections

In this last episode of the second season Nic and Rebecca get a visitor from the Department of Geology. One does not always use telescopes to study the stars. Chiara Paleari has been using ice cores to study our own star, the Sun, and has discovered evidence of an ancient solar storm. In this second season of the Meridian we are also bringing you some field reporting from the Nordic Optical Telesc

Parents and the NSU : Secrecy in National Socialist Youth Work in Denmark, 1932-1945

This article examines the role of secrecy in relations between the NSU, the largest Danish national socialist youth organization, and parents. The NSU struggled to recruit and retain members from Danish families with and without national socialist convictions. By analysing how NSU media and internal correspondence framed parents’ reluctance to join, this article traces the changing functions of NS

Ledningens vilja och avsikt : säkerhetspolicyer vid svenska förvaltningsmyndigheter

Alla organisationers ledningar vill ha en verksamhet som når upp till det som deras styrdokumenten vill förmedla. Ledningen har med sina säkerhetspolicyer visat sin vilja och avsikt med säkerhetatsarbetet och förväntar sig att dessa styrdokument ger resultat. Är det så enkelt? Kan ledningarna bli framgångsrikare gällande efterlevnad? Genom att ta reda på vad säkerhetspolicyer innehåller och om inn

Hyperspectral and Laser Speckle Contrast Imaging for Monitoring the Effect of Epinephrine in Local Anesthetics in Oculoplastic Surgery

PURPOSE: Epinephrine is used in local anesthetics to induce vasoconstriction and thus reduce bleeding and prolong the anesthetic effect. Finding the optimal delay between the administration of the anesthetic and skin incision to ensure vasoconstriction and minimize bleeding is important and has recently become the subject of debate. This is the first study to assess blood perfusion and oxygen satu

Sub-micrometer morphology of human atherosclerotic plaque revealed by synchrotron radiation-based μCT—A comparison with histology

Histology is a long standing and well-established gold standard for pathological characterizations. In recent years however, synchrotron radiation-based micro-computed tomography (SRμCT) has become a tool for extending the imaging of two-dimensional thin sections into three-dimensional imaging of tissue blocks, enabling so-called virtual histology with arbitrary clipping planes, volumetric renderi

Standardizing the freeze-thaw preparation of growth factors from platelet lysate

BACKGROUND: Over the past decades, the focus on the regenerative properties of platelets (PLTs) has intensified and many PLT-derived growth factors are readily used in medical settings. A general lack of standardization in the preparation of these growth factors remains, however, and this study therefore examines the dynamics of growth factors throughout the freeze-thaw procedure.STUDY DESIGN AND

Composition of growth factors and cytokines in lysates obtained from fresh versus stored pathogen-inactivated platelet units

BACKGROUND: Platelet lysate is a readily available source of growth factors, and other mediators, which has been used in a variety of clinical applications. However, the product remains poorly standardized and the present investigation evaluates the composition of platelet lysate obtained from either fresh or stored pathogen-inactivated platelet units.MATERIALS AND METHODS: Platelet pooled units (

Clinical associations of ESR2 (estrogen receptor beta) expression across thousands of primary breast tumors

Estrogen receptor alpha (ERα, encoded by ESR1) is a well-characterized transcription factor expressed in more than 75% of breast tumors and is the key biomarker to direct endocrine therapies. On the other hand, much less is known about estrogen receptor beta (ERβ, encoded by ESR2) and its importance in cancer. Previous studies had some disagreement, however most reports suggested a more favorable

Seeds of Transformative Learning: Investigating Past Experiences From Implementing Nature-Based Solutions

Nature-based solutions (NBS) attract a growing interest in research and practice due to their potential to address climate change while improving human health and well-being and safeguarding biodiversity. The integration of the NBS concept in urban governance, however, is still emerging and it faces regulatory, political, financial and cognitive barriers. While the literature acknowledges an incre