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Despite decades of research on the pathophysiology of depression, the development of new therapeutic interventions has been slow, and no biomarkers of treatment response have been clinically implemented. Several lines of evidence suggest that the clinical and biological heterogeneity among patients with major depressive disorder (MDD) has hampered progress in this field. MDD with low-grade inflamm
Beijing's interest in the African continent is strong. For some time, China has been investing considerable capital to increase its influence in many sub-Saharan nations, often rich in raw materials and resources considered essential for Chinese industrial growth. In this respect, a very interesting case concerns Tanzania, a significant African state facing the Indian Ocean that has recently estab
BackgroundBacteraemia with species in the genus Campylobacter is rare, and knowledge of the disease course in comparison to Campylobacter enteritis is limited.MethodsThis is a retrospective population-based study. Episodes of Campylobacter bacteraemia, and Campylobacter enteritis with a concurrent negative blood culture, that occurred between 2015 and 2022 in southern Sweden were identified throug
Monitoring natural events at ultrafast timescales is a prerequisite for our continued understanding of physical, chemical and biological processes. Due to exponential advancements in knowledge and optical technology, the field of ultrafast videography has seen a sudden uptick in activity beginning in the mid-2010s. Today, the field has matured past its infancy and is slowly becoming a standard too
Students’ beliefs about division by zero and numbers on the number line werestudied through explanations of the concepts in questionnaires and interviewsduring their teacher education to become primary school teachers in the years4–6. The concepts were chosen for students’ proven cognitive challenges incoping with them, with the aim to add to the existing knowledge in terms ofspecific and general
A physics lecture and a mathematics lecture, by the same teacher and partly thesame students, were studied at upper secondary school. Both lectures coveredordinary differential equations. The main aim of the present paper was to investigate the teacher’s different and similar ways to handle related mathematicalcontent in the two school subjects. The findings show a structural use of mathematics wi
Humans are expert percievers of behavioural properties, including the timing of movements. Even short hesitancies and delays can be salient depending on the context. This article presents results from a pilot study on time delays in a human-robot interaction setting using the Wizard of Oz paradigm. Participants (n=17) played Tic-Tac-Toe with the humanoid robot Epi. They were randomized into one of
BackgroundCerebral small vessel disease can be identified using magnetic resonance imaging, and includes white matter hyperintensities, lacunar infarcts, cerebral microbleeds, and brain atrophy. Cerebral small vessel disease and chronic kidney disease share many risk factors, including hypertension. This study aims to explore an association between chronic kidney disease and cerebral small vessel
In Sweden, extensive use and the inherent heterogeneity of train traffic have significantly increased the sensitivity of the train system so that the delay of one train can easily propagate to others. Repeated experiences with train delays can lead passengers to perceive that railway transportation is unreliable. Despite being considered a green mode of transport, this environmental benefit truly
Vid utformning och dimensionering av såväl anläggningskonstruktioner som enskilda byggnadsdelar måste vanligtvis ett flertal olika belastningssituationer analyseras. Utöver statiska lastfall kan det vara nödvändigt att beakta dynamiska laster, såsom explosions- eller stötlast. För att påvisa tillräcklig bärförmåga används i allmänhet datorbaserade beräkningsmodeller, ofta framtagna med finita elemA structural design process typically involves various load cases for which a sufficient load-bearing capacity must be demonstrated. In addition to static load cases, a verification of dynamic loads, such as blast and impact loading, may be required. To this end, the response can be estimated using computational models representing an idealized structure, often formulated using the finite element
Protists make up the vast diversity of eukaryotic life and play a critical role in biogeochemical cycling and in food webs. Because of their small size, cryptic life cycles, and large population sizes, our understanding of speciation in these organisms is very limited. We performed population genomic analyses on 153 strains isolated from eight populations of the recently radiated dinoflagellate ge
In muscular dystrophies, muscle fibers loose integrity and die, causing significant suffering and premature death. Strikingly, the extraocular muscles (EOMs) are spared, functioning well despite the disease progression. Although EOMs have been shown to differ from body musculature, the mechanisms underlying this inherent resistance to muscle dystrophies remain unknown. Here, we demonstrate importa
Knowledge of the neutron light-yield response is crucial to the understanding of scintillator-based neutron detectors. In this work, neutrons from 2–6 MeV have been used to study the scintillation light-yield response of the liquid scintillators NE 213A, EJ 305, EJ 331 and EJ 321P using event-by-event waveform digitization. Energy calibration was performed using a GEANT4 model to locate the edge p
The structure and thermoacoustic instability (TI) of premixed CH4/H2/air swirling flames were experimentally investigated for a range of hydrogen fraction (ηH2) up to 80% under different equivalence ratio (Φ) and swirl number (S) conditions. It is shown that the onset of TI is enhanced when increasing either ηH2, S, or Φ. The dominant frequency of TI increases dramatically with ηH2. The higher dom
Planetesimals are believed to form by the gravitational collapse of aerodynamically concentrated clumps of pebbles. Many properties of the objects in the cold classical Kuiper belt – such as binarity, rotation, and size distribution – are in agreement with this gravitational collapse model. Further support comes from the pebble-pile structure inferred for comet nuclei. For this study, we simulated
The input of strontium from aquatic resources in an omnivorous diet has been researched to a lesser degree than that of terrestrial sources, which, in specific sociocultural settings, complicates the study of provenance and mobility. To address this lack of research and to investigate forager mobility in an archipelago environment, where access to terrestrial resources was limited and earlier stud
Brain structure and function are intimately linked, however this association remains poorly understood and the complexity of this relationship has remained understudied. Healthy aging is characterised by heterogenous levels of structural integrity changes that influence functional network dynamics. Here, we use the multilayer brain network analysis on structural (diffusion weighted imaging) and fu
OBJECTIVE: Diffusion tensor imaging (DTI) along the perivascular space (ALPS) (DTI-ALPS)-by calculating the ALPS index, a ratio accentuating water diffusion in the perivascular space-has been proposed as a noninvasive, indirect MRI method for assessing glymphatic function. The main aim of this study was to investigate whether DTI-ALPS would reveal glymphatic dysfunction in idiopathic normal pressu
