Recently, this international task force reported the general considerations for bronchial challenge testing and the performance of the methacholine challenge test, a "direct" airway challenge test. Here, the task force provides an updated description of the pathophysiology and the methods to conduct indirect challenge tests. Because indirect challenge tests trigger airway narrowing through the act

OBJECTIVE: To estimate the prevalence of amyloid positivity, defined by positron emission tomography (PET)/cerebrospinal fluid (CSF) biomarkers and/or neuropathological examination, in primary progressive aphasia (PPA) variants. METHODS: We conducted a meta-analysis with individual participant data from 1,251 patients diagnosed with PPA (including logopenic [lvPPA, n = 443], nonfluent [nfvPPA, n =

Massive multiple-input multiple-output (MIMO) is becoming a mature technology, and has been approved for standardization in the 5G ecosystem. Although there is a large body of papers on the theoretical analysis of massive MIMO, the majority of relevant work assumes the simplified, yet overly idealistic, Kronecker-type model for spatial correlation. Motivated by the deficiencies of the Kronecker mo

Scandinavian Cardiovascular Journal, 2011, 45(S58), 35.

In this paper, we introduce a novel hybrid multiuser multiple-input multiple-output (MU-MIMO) architecture, with an emphasis on aggressive millimeter-wave (mmWave) hardware reduction methods, omitting the beam selection stage. We propose a simplification in a 28 GHz Rotman lens, where the number of beam-ports are reduced relative to the array ports resulting in the removal of a bank of RF switches

Favorable propagation (FP) and channel hardening are desired properties in massive multiple-input and multiple-output (MIMO) systems, where nearly optimal performance is achieved with linear processing techniques, such as maximal-ratio combining. To date, these properties have primarily been analyzed for statistical channel models, or ray-based models with very specific angular parameters and dist

The performance of linear multi-user multiple-input multiple-output (MU-MIMO) systems has been extensively studied for classical statistical channel models. In contrast, there is little analysis for ray-based models, which are physically motivated, feature prominently in standards and have been experimentally validated. Thus, we present a novel analysis framework for zero forcing (ZF) and maximal

Phase shifter-based hybrid beamforming has received a lot of attention at millimeter-wave frequencies for cellular communications. Nevertheless, the implementation complexity of such beamformers is rather high due to the complexities involved in designing and fabricating the required radio-frequency (RF) circuits. In contrast, lens-based RF beamformers significantly reduce the implementation compl

Multi-cell wireless systems usually encounter both intra-cell and inter-cell interference, which can be mitigated via coordinated multipoint (CoMP) transmission. Previous works on multi-cell analysis in the microwave band generally consider fully digital beamforming, requiring a complete radio-frequency chain behind each antenna. This is practically infeasible for millimeter-wave (mmWave) systems

This work demonstrates the sensitivity of lens antenna arrays operating at millimeter-wave (mmWave) frequencies. Considering a Rotman lens array in receive mode, our investigation focuses on its most imperative defect: aberration of electromagnetic (EM) energy. Aberration leads to spillover of electric fields to neighboring ports, reducing the lens' ability to focus the EM energy to a desired port

Massive multiple-input multiple-output (MIMO) is now making its way to the standardization exercise of future 5G networks. Yet, there are still fundamental questions pertaining to the robustness of massive MIMO against physically detrimental propagation conditions. On these grounds, we identify scenarios under which massive MIMO can potentially fail in Ricean channels, and characterize them physic

Lens–based massive multiple–input multiple–output (MIMO) systems have considerable potential to reduce signal processing cost at millimeter–wave frequencies. As a result, they are able to lower the effective channel dimension via beam selection, realized with a network of radio–frequency (RF) switches. However, lens arrays suffer from the inherent quantization of the beamspace, as well as errors d

What is a digital platform economy and what are its key policy implications? This report on Developing Platform Economies collects four chapters from researchers in the fields of economy, media and law to define, scrutinize and draw empirically based policy-recommendations for a European context, particularly in comparison to the US.What is a digital platform economy and what are its key policy implications? This report on Developing Platform Economies collects four chapters from researchers in the fields of economy, media and law to define, scrutinize and draw empirically based policy-recommendations for a European context, particularly in comparison to the US.

A search for charged Higgs bosons heavier than the top quark and decaying via H± → tb is presented. The data analysed corresponds to 36.1 fb−1 of pp collisions at s=13 TeV and was recorded with the ATLAS detector at the LHC in 2015 and 2016. The production of a charged Higgs boson in association with a top quark and a bottom quark, pp → tbH±, is explored in the mass range from mH± = 200 to 2000 Ge

Sustainability science is a wide and integrative scientific field. It embraces both complementary and contradictory approaches and perspectives for dealing with newer sustainability challenges in the context of old and persistent social problems. In this article we suggest a combined approach called social fields and natural systems. It builds on field theory and systems thinking and can assist su

Objective To evaluate the psychometric properties of the Fatigue Severity Scale (FSS), the Fatigue Impact Scale (FIS), and the Multidimensional Fatigue Inventory (MFI-20) in persons with late effects of polio (LEoP). More specifically, we explored the data completeness, scaling assumptions, targeting, reliability, and convergent validity. Methods A postal survey including FSS, FIS, and MFI-20 was

Introduction: Arterial stiffness is recognized as an intermediate phenotype and predictor of cardiovascular disease. Arterial stiffness is complex in origin with contributions from lifestyle and genetic factors. However, the association between single nucleotide polymorphisms (SNPs) and arterial stiffness remains unclear. Objective: The aim is to assess whether a multilocus genetic risk score (GRS