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Functional amyloids formed by the protein FapC in Pseudomonas bacteria are key structural components of Pseudomonas biofilms, which mediate chronic infections and also contribute to antimicrobial resistance. Here, we combine kinetic experiments with mechanistic modelling to probe the role of surfaces in FapC functional amyloid formation. We find that nucleation of new fibrils is predominantly hete
Background and objective: This publication represents a summary of the updated 2024 European Association of Urology (EAU) guidelines for non–muscle-invasive bladder cancer (NMIBC), TaT1, and carcinoma in situ. The information presented herein is limited to urothelial carcinoma, unless specified otherwise. The aim is to provide practical recommendations on the clinical management of NMIBC with a fo
Lead-free hybrid metal halide phosphors/crystals showing self-trapped exciton (STE) emission have been recently explored for thermography due to the strong temperature dependence of their photoluminescence (PL) lifetime (τ). However, realizing high-spatial-resolution thermography using polycrystalline powders or crystals presents a challenge. Moreover, the underlying mechanism of temperature-depen
The quality of lake ice is of uppermost importance for ice safety and under-iceecology, but its temporal and spatial variability is largely unknown. Here weconducted a coordinated lake ice quality sampling campaign across theNorthern Hemisphere during one of the warmest winters since 1880 and showthat lake ice during 2020/2021 commonly consisted of unstable white ice, attimes contributing up to 10
The future of AIS conferences, thrown into sharp relief by virtual innovations during the pandemic and the subsequent return to face-to-face conferences, is debated in this special issue. This editorial introduces the seven papers contained in the special issue and provides the context for the debate on the future of conferences in the AIS Community as well as pinpointing key contributions made by
Introduction: Postnatal perineal pain is prevalent following childbirth and can impact women both physically and emotionally. The aim of the study was to study the effect of collegial midwifery assistance on perineal pain and pain medication 1 month after birth and to investigate the associations between the type of tear and perineal pain, satisfaction with healing, and resumption of intercourse.
Staphylococcus argenteus was recently defined as a species and has previously often been mistaken for Staphylococcus aureus due to the difficulties of conventional laboratory methods to distinguish the two species. The clinical presentation of infections caused by S. argenteus is largely unknown, and its virulence has since the definition of the species been debated. Here we present, to our knowle
Aim: Aquatic-terrestrial transition zones contain features essential for many species that often benefit wetland biodiversity. Shallow flood-zone areas and reed beds are indicative of natural wetland habitats; however, how such features affect the native arthropod biodiversity in constructed wetlands is scarcely investigated. We asked how these shoreline features, as well as wetland shoreline prop
Natural climate oscillations can cause extreme events such as floods and droughts. The mid-1970s is known for the occurrence of a global Climate Shift, defined as a short period when both interannual and interdecadal climate oscillations changed phases, which led the climate to a new state. Climate Shift has affected many regions and is considered an unprecedented event. In this chapter, we descri
Background: High-resolution computed tomography (HRCT) is dependent on detailed morphology in diagnostic assessment of interstitial lung diseases. Photon-counting CT (PCCT) enables improved resolution while reducing radiation. Purpose: To compare if the image quality, detailed morphology, and radiation dose in HRCT of the lung improves with PCCT compared to energy-integrated CT (EICT). Material an
Background: Gaming disorder (GD) is a new official diagnosis in the International Classification of Diseases, 11th Revision, and with its recognition, the need to offer treatment for the condition has become apparent. More knowledge is needed about the type of treatment needed for this group of patients. Objective: This study aims to evaluate the effectiveness and acceptability of a novel module-b
Objectives: The use of magnetic resonance imaging (MRI) is safe from a long-term perspective since there are no known cumulative risks for patients or personnel. However, the technique comes with several acute risks associated with the powerful electromagnetic fields that are necessary to produce medical images. These risks include, among other things, a projectile hazard, loud noise, and the risk
Since Perestroika, Russian journalism has gone through a liberalization. However, the short lived apex of journalistic freedom that took place in the late 1980s and early 1990s was followed by a setback in particular since Putin’s accession to power in 2000. The situation for the freedom of the daily press has stagnated. Despite this, the findings based on qualitative text analysis of news article
Många flickor som skrivs in på Bup akut berättar att de någon gång blivit utsatta för ett sexuellt övergrepp. Dessa patienter är bland de mest utsatta. De har ofta en psykisk samsjuklighet och ett vacklande socialt sammanhang, faktorer som bidrar till deras sårbarhet. Skribenten har 20 års erfarenheter från Bup akut i Malmö. (1 kommentar)
Introduction: A subgroup of severe Traumatic Brain Injury (TBI) patients, known as ultra-severe (us-TBI), is most commonly defined as a post-resuscitation Glasgow Coma Scale (GCS) of 3–5. There is uncertainty on whether these critically injured patients can benefit from neurosurgical intervention. Research question: The available evidence regarding the decision-making and outcome following managem
ABP 959 is a biosimilar to the eculizumab reference product (RP), which is approved for the treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH). This multicenter, randomized, double-blind, active-controlled, two-period crossover study randomized eculizumab RP-treated patients with PNH to one of two treatment sequences (ABP 959/eculizumab RP or eculizumab RP/ABP 959) to evaluate th
This paper examines the role of policy in China’s digital and green (twin) transition, building on a qualitative study of a large corpus of policy documents in green and digital domains. We analyse the multi-level governance of these transitions for three regional case studies: Shanghai, Wuhan and Hangzhou. We find that regions both adopt and adjust green and digital aims and means differently fro
