Importance: Associations between putative risk factors and psychiatric and substance use disorders are widespread in the literature. Basing prevention efforts on such findings is hazardous. Applying causal inference methods, while challenging, is central to developing realistic and potentially actionable etiologic models for psychopathology. Observations: Causal methods can be divided into randomi

Over the past ten years, significant industry, policy, and scientific attention has been given to the ‘circular economy’, which aims to create a more sustainable society by decoupling economic growth from resource consumption. Firms are expected to play a significant role in the shift to a circular economy model by implementing circular business models that encourage prolonged use of products, com

Diffusion MRI may enable non-invasive mapping of axonal microstructure. Most approaches infer axon diameters from effects of time-dependent diffusion on the diffusion-weighted MR signal by modeling axons as straight cylinders. Axons do not, however, propagate in straight trajectories, and so far the impact of the axonal trajectory on diameter estimation has been insufficiently investigated. Here,

Atmospheric inverse modeling is a method for reconstructing historical fluxes of green-house gas between land and atmosphere, using observed atmospheric concentrations and an atmospheric tracer transport model. The small number of observed atmospheric concentrations in relation to the number of unknown flux components makes the inverse problem ill-conditioned, and assumptions on the fluxes are nee

Den digitalisering som för närvarande äger rum inom hälso- och sjukvårdssektorn ställer både nya krav och öppnar för nya möjligheter för enskilda medborgare, vårdpersonal samt olika aktörer i samhället. I många av de e-hälsolösningar som utvecklas finns bakomliggande tankar om ökad egenmakt (empowerment) för patienten genom att denne skall få ökad kontroll över sin egen hälsa och den information sThe digitalization that currently is taking place in healthcare raises questions about how this development, with visions of more patient participation and patient empowerment, changes this sector and what role eHealth can play in these changes. The term civic health technologies (Invånartjänster) is used in Sweden to describe eHealth in the healthcare sector that is developed and deployed by the

Insect herbivory can have important consequences for the functioning of terrestrial ecosystems. Despite a growing recognition of the role of herbivores in above-ground–below-ground interactions, our current understanding is mainly restricted to studies of vertebrates in grassland and tundra ecosystems, while ecosystems with tree-like canopies (termed forests below) and invertebrates remain underst

Aim: Dipeptidyl peptidase-4 (DPP-4) inhibition has effects on both fasting and postprandial glucose. However, the extent of this effect over the whole day and whether different DPP-4 inhibitors have the same effects have not been established. We therefore explored the whole day effects of three different DPP-4 inhibitors versus placebo on glucose, islet and incretin hormones after ingestion of bre

A series of 3-deoxy-3-N-arylated-β-d-galactoside and -guloside derivatives have been synthesized by cesium fluoride/trimetylsilylaryl triflate-mediated benzyne generation and N-arylation of 3-deoxy-3-amino-β-d-galactosides and -gulosides, respectively. Evaluation as ligands to galectin-1, 2, 3, 4N (N-terminal domain), 4C (C-terminal domain), 7, 8N, 8C, 9C, and 9N revealed that the galactosides sel

The present paper argues that experimental phenomenology has an important role to play in research on mindfulness. Experimental phenomenology is defined as a subcategory of phenomenology (defined as the science of our subjective experience of being in the world), which explores the effects of intentional variations of subjective experiencing (direction of attention and choice of attitude) on subse

We argue that the two temporal cognition systems are conceptually too confined to be helpful in understanding the evolution of temporal cognition. In fact, we doubt there are two systems. In relation to this, we question that the authors did not describe the results of our planning study on ravens correctly, as this is of consequence to their theory.

We introduce a new method for constructing complex-valued r-harmonic functions on Riemannian manifolds. We then apply this for the important semisimple Lie groups SO(n) , SU(n) , Sp(n) , SLn(R) , Sp(n, R) , SU(p, q) , SO(p, q) , Sp(p, q) , SO∗(2 n) and SU∗(2 n).

Purpose: Few studies have reported non-acute long-term morbidity rates in children with intestinal malrotation. The aim of this study was to investigate the rate of constipation in children undergoing Ladd's procedure for isolated intestinal malrotation. Methods: This retrospective study included children aged

Local governments have come to play an increasingly active role in addressing current environmental challenges. In addition to improving the environmental performance of a specific city, such initiatives can potentially spur policy change at other levels of government and thereby contribute to the addressing of global environmental challenges. This type of interplay between local and higher levels

This paper studies how immigrant–native intermarriages in Sweden are associated with individual characteristics of native men and women and patterns of assortative mating. Patterns of educational- and age-assortative mating that are similar to those found in native–native marriages may reflect openness to immigrant groups, whereas assortative mating patterns that indicate status considerations sug

This chapter aims to give an overview of the process of interactive model building in macromolecular neutron crystallography for the researcher transitioning from X-ray crystallography alone. The two most popular programs for refinement and model building, phenix.refine and Coot, respectively, are used as examples, and familiarity with the programs is assumed. Some work-arounds currently required