Domino synthesis of 4-vinyl-oxazoles - 1,2-rearrangement cascades en route to siphonazole B
A novel tandem cyclocondensation/1,2-oxazole rearrangement cascade reaction for the synthesis of 4-vinyl oxazoles from γ-chloro-propargylamines was developed and applied towards a short modular synthesis of natural product siphonazole B. The proposed seven-step route, enabled by the use of 4-vinyl oxazoles as precursors for 4-carboxyl oxazoles, would be the shortest to date. Simply removing the ca
