Importance: Antiamyloid immunotherapies against Alzheimer disease (AD) are emerging. Scalable, cost-effective tools will be needed to identify amyloid β (Aβ)-positive patients without an advanced stage of tau pathology who are most likely to benefit from these therapies. Blood-based biomarkers might reduce the need to use cerebrospinal fluid (CSF) or positron emission tomography (PET) for this. Ob

Objective: Incisional negative pressure wound therapy (iNPWT) applied over all incisions after lower extremity bypass in the prevention of surgical site infections (SSIs) is unclear. The primary and secondary aims of this study were to investigate if prophylactic iNPWT after the elective lower extremity bypass prevents SSI and other surgical wound complications. Methods: This was a multicenter, pa

The ionizable-lipid component of RNA-containing nanoparticles controls the pH-dependent behavior necessary for an efficient delivery of the cargo - the so-called endosomal escape. However, it is still an empirical exercise to identify optimally performing lipids. Here, we study two well-known ionizable lipids, DLin-MC3-DMA and DLin-DMA using a combination of experiments, multiscale computer simula

Purpose: We assessed long-term outcomes in acutely admitted adult patients with delirium treated in intensive care unit (ICU) with haloperidol versus placebo. Methods: We conducted pre-planned analyses of 1-year outcomes in the Agents Intervening against Delirium in the ICU (AID-ICU) trial, including mortality and health-related quality of life (HRQoL) assessed by Euroqol (EQ) 5-dimension 5-level

Background: Most family studies on venous thromboembolism (VTE) have focused on first-degree relatives. Objectives: We took a pedigree-based approach and examined the risk of VTE and cardiometabolic disorders in offspring from extended pedigrees according to the densities of VTE in pedigrees. Methods: From the Swedish population, we identified a total of 482 185 pedigrees containing a mean of 14.2

Frihetstiden driver fram ett unikt statsskick i Sverige, världens första tryckfrihetslag och en rad civila rättigheter. Tankar om att makten ska var lojal mot folket, snarare än mot Gud och kungen, är upptakten till genomgripande samhällsomvälvningar som tar fart med den europeiska upplysningen.

The use of artificial intelligence (‘AI’) is ubiquitous in society today. It has contributed towards advancements in diverse fields such as healthcare, transportation, public administration and in helping humanity to solve pressing challenges such as climate change. As AI increasingly plays a larger role within our daily lives and in society, it is inevitable that human rights issues will arise in

A stencil-adaptive SBP-SAT finite difference scheme is shown to display superconvergent behavior. As proof of concept, applied to the linear advection equation, it has a convergence rate O(Δx4) in contrast to a conventional scheme, which converges at a rate O(Δx3).

BackgroundRevised diagnostic criteria for infective endocarditis (IE), the 2023 Duke-ISCVID criteria, were recently presented and need validation. Here, we compare the 2000 modified Duke criteria for IE with Duke-ISCVID among patients with bacteremia and relate the diagnostic classification to IE-treatment.MethodsWe reanalyzed patient cohorts with Stapylococcus aureus, Staphylococcus lugdunensis,

Maritime archaeology excavations, even in a more complex environment, have the same objectives and requirements as terrestrial ones: documenting digging operations to analyze data in the best way, interpreting it, and producing new knowledge for the benefit of multiple communities. 3D documentation and management methodologies have spread widely among practitioners; however, 3D comprehensive tools

Transportsektorn är en central och nödvändig del av det moderna samhället samtidigt som den också ger upphov till flera negativa samhällseffekter. Sådana effekter är till exempel emissioner av växthusgaser, partiklar och andra föroreningar som har en negativ påverkan på människors hälsa och miljön. Andra effekter är till exempel buller och olyckor som har en negativ effekt på människors hälsa. Syf

More granular grading scales provide a more accurate assessment of achievement and thus provide students with more informative feedback on their performance. Using Swedish administrative data and exploiting a natural experiment, we identify the effects of moving from a system with three passing grades to one with five passing grades. Students receiving more informative grades are less likely to gr

Receptor tyrosine kinase KIT is frequently activated in acute myeloid leukemia (AML). While high PRL2 (PTP4A2) expression is correlated with activation of SCF/KIT signaling in AML, the underlying mechanisms are not fully understood. We discovered that inhibition of PRL2 significantly reduces the burden of oncogenic KIT-driven leukemia and extends leukemic mice survival. PRL2 enhances oncogenic KIT

In spite of the similar structural and genomic organization of human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2), striking differences exist between them in terms of replication dynamics and clinical manifestation of infection. Although the pathomechanism of HIV-1 infection is well characterized, relatively few data are available regarding HIV-2 viral replication and its interaction wi