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A simple method for large-scale generation of dopamine neurons from human embryonic stem cells.

Dopamine (DA) neurons derived from human embryonic stem cells (hESCs) are potentially valuable in drug screening and as a possible source of donor tissue for transplantation in Parkinson's disease. However, existing culture protocols that promote the differentiation of DA neurons from hESCs are complex, involving multiple steps and having unreliable results between cultures. Here we report a simpl

Knowledge, Practices, and Restrictions Related to Menstruation among Young Women from Low Socioeconomic Community in Mumbai, India.

The main objective was to assess knowledge, practices, and restrictions faced by young women regarding their menstrual hygiene. The views of adult women having young daughters were also included and both views were compared. In addition, the factors influencing the menstrual hygiene practices were also studied. The study was carried out during 2008 in Mumbai, India. The mixed methods approach was

Whole-Body and Microenvironmental Localization of Radium-223 in Naïve and Mouse Models of Prostate Cancer Metastasis.

Bone-metastatic, castration-resistant prostate cancer (bmCRPC) represents a lethal stage of the most common noncutaneous cancer in men. The recent introduction of Radium-223 dichloride, a bone-seeking alpha particle (α)-emitting radiopharmaceutical, demonstrates statistically significant survival benefit and palliative effect for bmCRPC patients. Clinical results have established safety and effica

Expression of Fatty Acid Amide Hydrolase (FAAH) in Human, Mouse, and Rat Urinary Bladder and Effects of FAAH Inhibition on Bladder Function in Awake Rats.

BACKGROUND: Cannabinoid receptor (CB)-mediated functions may be involved in the regulation of bladder function, but information on endocannabinoid signals during micturition is scarce. OBJECTIVE: Investigate the expression of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) in human, rat, and mouse bladders and study the effects of inhibition of FAAH during urodynamics in awa

Characterization of the platelet-derived growth factor beta-receptor kinase activity by use of synthetic peptides

Synthetic peptides derived from the sequence surrounding tyrosine-857 in the human platelet-derived growth factor (PDGF) beta-receptor were used to elucidate the requirement for length and presence of negative and positively charged amino acids in substrates of the PDGF beta-receptor protein tyrosine kinase. The measured Km for the different peptides were all in the range 1-10 mM. A peptide of onl

High-order Harmonic-generation Using High-power Lasers

An introduction to high-power lasers and strong-field laser-atom interactions is given, and the main experimental and theoretical results concerning high-order harmonic generation are reviewed. The single atom response as well as the macroscopic phase-matching effect is discussed. The formation and extent of the characteristic plateau in the harmonic spectra are discussed in terms of a physical pi

An endometrial stromal sarcoma cell line with the JAZF1/PHF1 chimera

Endometrial stromal sarcomas (ESS) are rare malignancies, accounting for less than 10% of uterine sarcomas. Apart from the chromosomal rearrangement t(7;17)(p15;q21), which leads to the JAZF1/SUZ12 chimera, cytogenetic studies have shown that the chromosome band 6p21 is often rearranged in ESS. The translocation partners involved in the 6p21 rearrangements differ among the tumors, but chromosome 7

The Sango Language and Its Lexicon (Sêndâ-yângâ tî Sängö)

This doctoral dissertation is an overview of the recently arisen Sango language spoken in the Central African Republic. The overview contains a sociolinguistic and linguistic dimension with a lexical-semantic focus. The study is set within a multidisciplinary framework including a functional-typological perspective, language change induced by contact, and language planning. The study shows that th

Local factors driving the diffusion of solar photovoltaics in Sweden: A case study of five municipalities in an early market

Local factors influencing the rate of diffusion of residential photovoltaic (PV) systems are insufficiently understood. This multiple-case study explored five Swedish municipalities which have had a particularly high PV density in terms of number of installations per capita, compared to other municipalities. The aim was to identify and assess local factors that could explain these relatively high