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Structural and Functional Studies of the Wilms' Tumour 1 Protein (WT1) in Interaction with Nucleic acids

The WT1 protein, a product of the Wilms’ tumour 1 gene (WT1) is a zinc finger transcription factor implicated in a number of cellular processes particularly involved in the development of the urogenital system. Mutations in this gene have been implicated in abnormal development of the urogenital system resulting in syndromes such as the Denys-Drash, WAGR and Frasier and in the childhood kidney mal

Segregation of Women in Public Space in Iran

As part of a systematic endeavor to Islamize the society, Iranian Islamic government has bestowed efforts to create gender-segregated public urban spaces. The gender segregation was formally enforced in public places such as schools, sport halls, swimming pools, transportation facilities, etc. in last three decades. The most recent effort of the government includes “women-only parks”, claimed to b

A 0.8V, 7uA, rail-to-rail input/output, constant Gm operational amplifier in standard digital 0.18um CMOS

A two-stage amplifier, operational at 0.8V and drawing 7/spl mu/A, has been integrated in a standard digital 0.18/spl mu/m CMOS process. Rail-to-rail operations at the input are enabled by complementary transistor pairs with g/sub m/ control. The efficient rail-to-rail output stage is biased in class AB. The measured DC gain of the amplifier is 75dB, and the unity-gain frequency is 870kHz with a 1

Cytonuclear Interactions and the Economics of Mating in Seed Beetles

Recent studies have uncovered an abundance of non-neutral cytoplasmic genetic variation within species, which suggests that we should no longer consider the cytoplasm an idle intermediary of evolutionary change. Nonneutrality of cytoplasmic genomes is particularly intriguing, given that these genomes are maternally transmitted. This means that the fate of any given cytoplasmic genetic mutation is

Reduction of arterial partial volume effects for improved absolute quantification of DSC-MRI perfusion estimates: Comparison between tail scaling and prebolus administration.

To evaluate and mutually compare the tail-scaling approach and the prebolus administration concept for reduction of arterial partial volume effects (PVEs), because reproducible absolute quantification of cerebral blood flow (CBF) by dynamic susceptibility contrast magnetic resonance imaging (MRI) is often hampered by PVEs in the arterial input function (AIF) registration.

Critical leadership studies: The case for critical performativity

Existing accounts of leadership are underpinned by two dominant approaches: functionalist studies, which have tried to identify correlations between variables associated with leadership; and interpretive studies, which have tried to trace out the meaning-making process associated with leadership. Eschewing these approaches, we turn to an emerging strand of literature that develops a critical appro