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Background: The MEK-ERK1/2 and PKC pathways play critical roles in regulating functional changes in tissues, but their interplay remains poorly understood. The vasculature provides an ideal model to study these pathways, particularly under conditions of flow cessation, which is highly relevant to ischemia and other cardiovascular diseases. This study examined the independent roles, additive effect
Efforts to develop the wild berry industry in Sweden and internationally call for increased knowledge about the consumer perspective. Our objective is to investigate attitudes, product associations, consumption patterns, and foraging behaviour regarding bilberries, with an online survey using a nationally representative sample (N = 2010). The data were analysed with regression and multinomial test
Objective: Maintenance olaparib demonstrated clinical activity for progression-free survival in patients without a germline BRCA1 and/or BRCA2 mutation (non-gBRCAm) who had platinum-sensitive relapsed ovarian cancer in the phase IIIb, open-label, single-arm, non-comparator, international OPINION trial (NCT03402841). We report final overall survival (OS; secondary endpoint), prespecified secondary
In 2005, the Paediatric Radiation Oncology Society (PROS), a multi-professional association to promote radiotherapy for children and young people, was created. Its mission has been to educate those involved in this field, and to improve the standards of radiation oncology care for children, adolescents, and young adults across the globe, not least in less privileged settings where the majority of
The 19th Topical Meeting on Laser Applications to Chemical, Security, and Environmental Analysis (LACSEA) was held in Toulouse, France from 15–19 July 2024, as part of the Optica Optical Sensing Congress, with a return to in-person attendance. The meeting featured 21 sessions covering recent advances in laser and optical spectroscopy, sensor design, and diagnostic application. A total of 125 contr
TOI-1266 is a benchmark system of two temperate (<450 K) sub-Neptune-sized planets orbiting a nearby M dwarf exhibiting a rare inverted architecture with a larger interior planet. In this study, we characterize transit timing variations (TTVs) in the TOI-1266 system using high-precision ground-based follow-up and new TESS data. We confirm the presence of a third exterior nontransiting planet, TOI-
This paper argues that we have a moral obligation to implement certain health technologies even if we have limited or incomplete evidence of their effectiveness. The focus is on technologies used in non-emergency settings, as opposed to “exceptional cases” such as compassionate use and emergency approvals during public health emergencies. A broadly plausible moral principle – the Ecumenical Princi
Background: Although lipoprotein(a) (Lp[a]) has been associated with acute myocardial infarction (MI), the relationship between Lp(a) and the presence of high-risk “vulnerable” coronary plaques has not been studied. Objectives: The aim of this study was to investigate whether specific lipoproteins are associated with pancoronary plaque volume and lipid deposition vs the development of non-flow-lim
Systemic vasculitis, common forms of which include anti-neutrophil cytoplasmic antibody-associated small-vessel vasculitis, large-vessel vasculitis and Behçet syndrome, are frequently complicated by arterial or venous thrombotic events (AVTEs). Newly identified entities such as DADA2 (deficiency of adenosine deaminase 2) and VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome
Airborne wear particle emissions from dry clutches have been investigated in terms of particle mass and number concentration, size distribution, and chemical composition of a single clutch material. This paper presents a detailed continuation of the investigation. Clutch plates of two different friction materials, i.e., from different manufacturers but for the same automobile applications, are tes
Sepsis is a life-threatening condition caused by a dysregulated host response to an infection and is a leading cause of death worldwide. The condition is variable, which in combination with insufficient clinical markers, makes it challenging to predict when infection will progress to sepsis and to categorize patients into homogeneous patient subgroups. In this study, we demonstrate the use of acou
This study proposes a novel devolatilization model based on a convolutional neural network (CNN), employing quantified coal chemical structure features as input. Initially, a reliable method was developed to quantify the average/heterogeneous properties of coal structures using high-resolution micro-Raman spectroscopy. The evolution of chemical structure with increasing coal rank was investigated
We are interested in studying sets of the form U ( α ) := { x ∈ X : ∃ M = M ( x ) ⩾ 1 such that ∀ N ⩾ M , ∃ 1 ⩽ n ⩽ N such that d ( T n x , x ) ⩽ | λ | − α N } , where ( X , T , d ) is our metric dynamical system and | λ | > 1 . Although many results exist for the one dimensional case, not as many are known for systems in higher dimensions and especially in the hyperbolic case. We consider X = T 2
