Map label placement is an important task in map production, which needs to be automated since it is tedious and requires a significant amount of manual work. In this paper, we identify five cartographic labeling situations that present challenges by causing intensive manual work in map production of city wayfinding maps, e.g., label placement in high density areas, utilizing true label geometries

This paper discusses a Python interface for the recently published Dune-Fem-DG module which provides highly efficient implementations of the discontinuous Galerkin (DG) method for solving a wide range of nonlinear partial differential equations (PDEs). Although the C++ interfaces of Dune-Fem-DG are highly flexible and customizable, a solid knowledge of C++ is necessary to make use of this powerful

Although many therapeutically active peptides and proteins have been developed there is a lack of topical pharmaceutical products on the market containing these sensitive molecules. The main reasons may be lack of stability and a limitation of larger molecules to penetrate into the skin. In this study we investigated the possibility to develop a peptide formulation which enables follicular permeat

Background: The immune checkpoint receptor lymphocyte-activation gene 3 (LAG3) is a new target for immune checkpoint blockade (ICB), but the effects of LAG3 on atherosclerosis are not known. Objectives: The aim of the study was to evaluate the role of LAG3 on plaque inflammation using murine hypercholesterolemic models of atherosclerosis. Methods: To study the role of LAG3 in atherosclerosis, we i

The tourism sector declared a climate emergency in 2020. It is against this background that this Curated Collection on Climate Change and Tourism is launched. A bibliometric analysis of 1290 articles reviews the 35-year development of climate change and tourism scholarship, including major research themes, key knowledge gaps, and our capacity to deliver the enormous knowledge requirements for an e

The latticework duct plays an important role in turbine blade cooling for aircraft engines. The present numerical research provided information about the thermal performance in latticework ducts with different endwall shapes. Each latticework duct analyzed in this study had a crossing angle of 90° and 11 sub channels on both the two sides of the endwall. A numerical investigation was conducted at

Background: Inflammatory bowel disease (IBD) has been linked to adverse pregnancy outcomes, but it is unclear how risks vary by histological activity. Methods: We performed a nationwide study of Swedish women diagnosed with IBD 1990–2016 and a pre-pregnancy (

Internet-delivered cognitive behavioural therapy (ICBT) is an efficacious treatment for social anxiety disorder (SAD) in youth. However, we have limited knowledge about patient characteristics that may be associated with better (or worse) treatment outcome. Particularly concerning factors suggested to be involved in the maintenance of SAD (e.g., anticipatory anxiety and post-event processing). The

A dyadic algorithm for diagonalizing an arbitrary positive definite band matrix, referred to as a band Gramian, is obtained to efficiently orthogonalize the B-splines. The algorithm can be also used as a fast inversion method for a band Gramian characterized by remarkable sparsity of the diagonalizing matrix. There are two versions of the algorithm: the first one is more efficient and is applicabl

The lakes in the arid or semi-arid regions of western China are more sensitive to climate changes, and lake levels are considered as a direct indicator of regional climate variability. In this study, we combined satellite altimetry data from ICESat-1 with a smaller footprint and higher accuracy (compared to radar altimetry) and CryoSat-2 with a higher resolution in the along-track direction to mon

Background: In adults and adolescents with asthma, use of ≥3 short-acting β2-agonist (SABA) canisters/year is associated with increased exacerbation risk. Whether this association is present in younger children remains unknown. In this SABA use IN Asthma (SABINA) Junior study, we assessed the association of SABA collection with exacerbation risk in the general Swedish pediatric asthma population.

A significant number of individuals experience post-COVID-19 symptoms, but knowledge of perceived consequences and life satisfaction is lacking. Here, we investigate perceived consequences regarding everyday life, health, physical activity and work post-COVID-19 and factors associated with low life satisfaction. A total of 766 people (mean age 48; 672 women) experiencing post-COVID-19 symptoms at

Evaluating the structure of soil prior to building construction is valuable in a large variety of geotechnical and civil engineering applications. To built an effective framework for assessing the strength of the stabilised soil, the presented workflow includes a complex approach of simplex lattice design and X-ray diffraction for the analysis of soil structure. Different from the traditional in s

Loess deposits are the most extent continental archives of climatic- and environmental change and represent important components of local and global dust systems. Consequently, their geochemistry provides an excellent basis for studying climate oscillations on land and how these affect processes in the terrestrial system. It is, however, challenging to assess information archived in loess records

The most common noise in geophysical data is probably interference from powerlines. This noise manifests itself as a sinusoidal signal oscillating at the fundamental 50 or 60 Hz frequency of the power grid and as harmonic components oscillating at integer multiples. Many different mitigation strategies, tailored for the specific geophysical method, have been developed to target powerline noise. On

Evolutionary changes in brain and craniofacial development have endowed humans with unique cognitive and social skills, but also predisposed us to debilitating disorders in which these traits are disrupted. What are the developmental genetic underpinnings that connect the adaptive evolution of our cognition and sociality with the persistence of mental disorders with severe negative fitness effects

The world of environmental microscopy provides the possibility to study and analyze transformations and reactions during realistic conditions to understand the processes better. We report on the design and development of a metal-organic chemical vapor deposition (MOCVD) system integrated with an environmental transmission electron microscope intended for real-time investigations of crystal growth.

Morphology and facet engineering have been proved efficient strategies to prepare high-performance photoelectrochemical (PEC) materials. WO3/BiVO4 heterojunction photoanodes with different morphologies were prepared by simply controlling the amount of electrodeposited charge. The coral-like WO3/BiVO4 photoanode with the orientation growth of {110} and {011} active facets of BiVO4 exhibited the opt

Atmospheric mineral dust not only interacts with the climate system by scattering incoming solar radiation and affecting atmospheric photochemistry, but also contributes critical nutrients to marine and terrestrial ecosystems. In a high-resolution analysis of paleodust deposition, peat development and soil dust sources, we assess the interplay between dust deposition and bog development of the Dav