Noninvasive MGMT-promotor methylation prediction in high grade gliomas using conventional MRI and deep learning-based segmentations
BACKGROUND/OBJECTIVES: High grade gliomas (HGG) are aggressive brain tumors, most frequently glioblastoma and astrocytoma grade 4. Methylation of O6-methylguanine-DNA methyltransferase (MGMT) promoter in HGG is crucial for temozolomide efficacy. As MGMT promoter methylation (MGMTpm) assessment requires tumor tissue, magnetic resonance imaging (MRI) is of interest for non-invasive prediction. We ai
