Serum concentrations of two cartilage matrix proteins reflecting different aspects of cartilage turnover in relapsing polychondritis

Matrix proteins: Potentials as body fluid markers of changes in the metabolism of cartilage and bone in arthritis

Altered dynamics of cartilage and bone matrix in joint diseases results in increased release of macromolecules into synovial fluid (SF). Such macromolecules are increasingly explored as potential markers of damage and severity. This report focuses on the possibilities of using quantification of tissue specific markers for grading the tissue lesion at the molecular level in arthritis. The theoretic

Relationship between serum cartilage oligomeric matrix protein levels and disease progression on osteoarthritis of the knee joint.

Differential release of molecular markers in joint disease

Cartilage and bone, the principal tissues of the diar-throdial joint, are dynamic tissues with continuous matrix turnover. These tissues, like all connective tissues, contain few cells surrounded by an abundant matrix. The cells, e.g. the chondrocytes in cartilage, regulate both synthesis and degradation of the matrix constituents in response to various environmental factors, such as hormones, nut

Pristance-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by MHC and non-MHC genes

We present a novel animal model for rheumatoid arthritis induced with a well defined synthetic adjuvant oil, pristane. Two weeks after a single intradermal injection of 150 microliters of pristane, the rats developed severe and chronic arthritis. The inflammation was restricted to the joints and involved pannus formation, major histocompatibility complex (MHC) class II expression, and T lymphocyte

Cartilage markers in synovial fluid in symptomatic knee osteoarthritis

Serum biological markers as predictors of disease progression in osteoarthritis of the knee

HLA DRB1* typing and cartilage oligomeric matrix protein as predictors of joint destruction in recent onset rheumatoid arthritis

Radiographic osteoarthritis of the knee classified by the Ahlbäck and Kellgren & Lawrence systems for the tibiofemoral joint in people aged 35–54 years with chronic knee pain.

Cartilage matrix macromolecules in joint fluid of temporomandibular joints before and six months after diskectomy

The purpose was to investigate if antigenic fragments of aggrecan and cartilage oligomeric matrix protein (COMP) are detectable by enzyme-linked immunosorbent assay in lavage fluids from the temporomandibular joint (TMJ) and to examine if the relative content of these cartilage markers changes during development of osteoarthrosis (OA) after diskectomy. Lavage fluid was obtained at surgery and 6 mo

Storytelling as a tool of authentication in jazz discourse

Cartilage macromolecules and the development of new methods for the assessment of joint disease

Serum analyses of tissue derived macromolecules and markers of inflammation in early rheumatoid arthritis. Relation to development of joint destructions in hands and feet

SUMMARY We have previously shown that serum concentrations of cartilage oligomeric matrix protein (COMP) are increased early in rheumatoid arthritis (RA) patients who subsequently develop advanced large-joint destruction. A prognostic value for joint damage of serum concentrations of hyaluronan (HA) is also suggested by previous studies. In contrast, serum concentrations of bone sialoprotein (BSP)

Postero-anterior radiogram of the knee in weightbearing and semiflexion. Comparison with MR imaging

Increased serum levels of cartilage oligomeric matrix protein and bone sialoprotein in rats with collagen arthritis

Cartilage macromolecules in knee synovial fluid. Markers of the disease course in patients with acute oligoarthritis

OBJECTIVE To investigate the development of chronic joint symptoms in patients presenting with acute oligoarthritis including knee joint synovitis with effusion and explore whether prognostic information can be derived from initial synovial fluid concentrations of aggrecan and cartilage oligomeric matrix protein (COMP) for development of chronic joint symptoms. METHODS Retrospective follow up of

Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint

Bone scan and serum markers of bone and cartilage in patients with knee pain and osteoarthritis

Joint space width in the axial view of the patello-femoral joint: Definitions and comparisons with MR imaging

Increased serum levels of cartilage oligomeric matrix protein in chronic erosive arthritis in rats