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Aducanumab, a human IgG1 antibody with plaque-clearing effects and modest clinical benefit, binds selectively to aggregated Aβ via the N-terminal region. Yet, the molecular details of how the antibody engages Aβ1-42 fibrils remain unresolved. Using magic-angle spinning NMR, we show that binding of aducanumab preserves the overall architecture of the Aβ1-42 fibril core while inducing significant st

Following regulatory approval of anti-amyloid beta (Aβ) therapies, a better characterization of patients receiving these treatments is needed to guide clinical management and inclusion in future trials. This Alzheimer's Association-convened workgroup proposes a terminology, treatment-related amyloid clearance (TRAC), to reflect alterations in disease pathophysiology based on biomarker evidence for

Background: Distal pancreatic resection is associated with a high frequency of postoperative complications. The aim of this study was to characterize the effect of diabetes mellitus (DM) on short-term complications after distal pancreatectomy. Methods: Patients who underwent distal pancreatectomy between 1 January 2010 and 31 December 2020 were identified from the Swedish National Pancreatic and P

Dynamic task offloading is essential for real-time robotic applications, enabling them to adapt to fluctuating computational demands and maintain efficiency under changing conditions. This paper introduces a dynamic task offloading framework that incorporates monitoring, decision making, offloading triggering, and performance monitoring to optimize resource usage by offloading real-time tasks to e

Denna avhandling undersöker antropocentriska frihetsbegrepp och utvecklar en förståelse av interspecies frihet som ett relationellt tillstånd som möjliggör för människor och andra djur att leva ihop utan dominans. Frihet har traditionellt uppfattats som ett uteslutande mänskligt begrepp, grundat i hierarkiska strukturer som legitimerar förtrycket av andra djur. Med utgångspunkt i kritiska djurstudThis dissertation interrogates anthropocentric conceptions of freedom and develops an account of interspecies freedom as a relational condition enabling humans and other animals to flourish without domination. Freedom is traditionally conceived as an exclusively human concept, grounded in hierarchical structures that legitimise the oppression of other animals. Drawing on critical animal studies, e

Den här boken ger en introduktion till straffrättens påföljdssystem. Framställningen omfattar både det regelverk som gäller och de sammanhang som påverkar påföljdsbestämningen: straffprocessen, de principer och värden som bär upp systemet, frågor om straffets funktion och rättfärdigande samt den historiska utvecklingen av påföljdssystemet. Förutom att presentera påföljdsbestämningens övergripande

Background: Incisional hernia remains the most common complication of open abdominal surgery. The aim was to investigate whether a reinforced tension-line suture combined with standard 4: 1 small-bite closure reduces the 3-year incidence of computed tomography-detected incisional hernia in open colorectal cancer surgery. Methods: Patients aged > 18 years, scheduled for colorectal cancer resection

Directed movement is fundamental to animal behavior, yet the mechanisms underlying robust orientation remainincompletely understood. The ball-rolling dung beetle offers a unique model system for investigating these mechanismsdue to its distinctive navigational challenges: maintaining a straight-line trajectory while moving backwardand transporting a dung ball. In this thesis, I investigates orient

Background: Intraventricular hemorrhage (IVH) is a leading cause of neurodevelopmental impairment in preterm infants, driven by vascular rupture, intraventricular blood accumulation, and secondary injury. Hemolysis releases extracellular hemoglobin (Hb) into the cerebrospinal fluid (CSF), where it promotes oxidative stress, inflammation, and cytotoxicity. The endogenous Hb-scavenging protein hapto

The aim of this paper is to explore how Edmund Husserl's phenomenological account of empathy, as well as Emmanuel Levinas' critical reception of the same, could contribute with clarity to the debate over the relevance of empathy to social work ethics. I suggest that more attention should be given to the pre-reflective character of empathy, according to Husserl's account. This resonates with Levina

Objective: To investigate whether low daily doses of fluoridated milk, as an adjunct to oral hygiene routines with fluoridated toothpaste, can prevent caries development in enamel and dentine in adolescents. Material and methods: Adolescents (mean age 13 years) at three dental clinics in Sweden were enrolled to a randomised clinical trial (RCT) including baseline and 2-year follow-up examinations.

Rural populations in Europe face health inequalities due to a multitude of factors, including the higher prevalence of multi-morbidity, inadequate access to primary and secondary health care services, and widespread health workforce shortages. Although some challenges are also present in other contexts, the multitude and interconnectedness of these factors induce significant health inequalities. R

Since its inception in 1998, the Cuneiform Digital Library Initiative (https://cdli.earth) has become the global authority index for inscribed artifacts of the cuneiform world, providing an essential reference for a corpus of half a million historical documents that form an important part of the world’s written heritage. The CDLI infrastructure is now foundational to the study of the history of th

Background. Adults with intellectual disability (ID) experience marked mental health inequities, yet population-wide estimates that capture both primary- and specialist-care diagnoses remain scarce. Methods. Using nationwide Swedish registries, including primary care, specialist, inpatient, prescription drug, criminal, and suspicion registers, we included all individuals born in Sweden between 195

Bakgrund: Isoleringsvård innebär att patienten vårdas på ett sätt som begränsar smittspridningen. Trots frekvent användning av isoleringsvård inom slutenvården behövs ytterligare forskning om patienternas egna erfarenheter. Syfte: Att beskriva patienters erfarenheter av isoleringsvård på slutenvårdsavdelning vid smittsamma sjukdomar. Metod: Studien genomfördes som en icke-systematisk litteraturs

Covid-19 pandemin medförde många utmaningar och nya upplevelser för sjuksköterskor. Syftet med studien var att sammanställa och belysa sjuksköterskors upplevelser av att ge omvårdnad under Covid-19 pandemin inom slutenvården. Föreliggande studie är en icke-systematisk litteraturstudie med en induktiv ansats som är baserad på elva vetenskapliga artiklar. Resultatet består av två huvudteman, att mis