The response of childhood acute lymphoblastic leukemia (ALL) to dexamethasone predicts the long-term remission outcome. To explore the mechanisms of dexamethasone resistance in B cell ALL (B-ALL), we generated dexamethasone-resistant clones by prolonged treatment with dexamethasone. Using RNA-sequencing and high-throughput screening, we found that dexamethasone-resistant cells are dependent on rec

The bedrock of Skåne, the southernmost province of Sweden, has been targeted for geothermal feasibility studies since the late 1970s. An exploration project concerning the geothermal potential in the Romeleåsen Fault Zone was launched outside the town of Lund in 2001. Besides geophysical imaging of the thrust fault zone, the investigations included drilling and investigations of a 3701.8-m-deep e

Summary: This study assesses the impact of risk factors for fracture in women aged 80+ and 60–79. The results suggest that risk assessment which fits younger women may not be suited for the 80+ strata as many common risk factors are less predictive in the older compared to the younger cohort. Purpose: This study assesses whether the impact of classical risk factors for fracture due to osteoporosis

Several chemotherapeutic drugs are now considered to exert anti-tumour effects, by inducing an immune-promoting inflammatory response. Cisplatin is a potent chemotherapeutic agent used in standard medulloblastoma but not glioblastoma protocols. There is no clear explanation for the differences in clinical efficacy of cisplatin between medulloblastomas and glioblastomas, despite the fact that cisp

Hyperdiploidy, i.e. gain of whole chromosomes, is one of the most common genetic features of childhood acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly understood. Here, we report a proteogenomic analysis on matched datasets from genomic profiling, RNA-sequencing, and mass spectrometry-based analysis of >8,000 genes and proteins as well as Hi-C of primary patient samples f

Traditionally, diesel engine control has had to rely on indirect feedback variables and empirical open-loop maps because direct measurements of the variables representing high-level objectives, such as emissions, have not been available in production engines. With new sensors being developed, the opportunity opens to design the controller directly based on high-level objectives. In this paper, we

This paper describes how high-speed computer vision can be used in a motion control application. The specific application investigated is a dart catching robot. Computer vision is used to detect a flying dart and a filtering algorithm predicts its future trajectory. This will give data to a robot controller allowing it to catch the dart. The performance of the implemented components indicates that

Solid waste collection and hauling account for the greater part of the total cost in modern solid waste management systems. In a recent initiative, 3,300 Swedish recycling containers have been fitted with level sensors and wireless communication equipment thereby giving waste collection operators access to real-time information on the status of each container. In a previous study (Johansson, 2006)

Här redogörs för de senaste besluten inom Bird- Life Sveriges Taxonomikommitté (Tk) som togs på ett möte i december 2018 på Getterön. Detta är en förkortad version, den fullständiga – ”Rapport 10” – finns att ladda ner på birdlife.se/Tk. Tk:s Västpalearktislista har uppdaterats med samtliga ändringar.Här redogörs för de senaste besluten inom Bird- Life Sveriges Taxonomikommitté (Tk). vilka togs på ett möte i december 2018 på Getterön. Detta är den fullständiga rapporten, inkluderande referenser. En kortare version finns i Vår Fågelvärld nummer 2/2019. Tk:s Västpalearktislista har uppdaterats med samtliga förändringar och heter nu VP5. Likaså har Namnlistan över svenska fågel

Veterligen sympatiserade inga svenska nationalekonomer med Hitlers Tredjerike. I denna artikel riktas inte desto mindre uppmärksamhet mot en av de mestframträdande ekonomerna, Gustav Cassel. Detta mot bakgrund av att hanunder mellankrigstiden, fram till Hitlers maktövertagande 1933, var mycketengagerad i och för Tyskland. Hur hanterade han den tyska genomklappningen?I Cassels memoarer framstår Naz

This paper presents and discusses how to support disciplinary communities of academic teachersto create a lasting change in educational culture. By stressing the similarities with the fully accepted research culture and their research knowledge this have been possible. Evaluations consistentlyshow that participants appreciate the collegial approach. It offers them an opportunity to deal withchalle

In this paper, we have analyzed a nationwide debate following the introduction of an individual meritsystem for educational development. When reforms are aimed towards research, even the toughestdiscussions can most often be resolved when arguments are backed by evidence. Not surprisingly, as this goes hand in hand with the language and mindset of the receivers in the researchcommunity. But, when

The role of raw plantain flour (RPF) and its citric acid (CA)-esterified counterpart (EPF) on the carbohydrate nutritional properties of cookies was investigated. Cookies were elaborated with commercial wheat flour (CWF), RPF, EPF, or a CWF-EPF blend, and assessed for composition, starch digestibility, texture and sensory properties. EPF-cookie showed the lowest digestible starch (DS) content and