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Popular Abstract in Swedish p53 Ñett protein som kan fŒ leukemiceller att bli mera mogna Vid akut leukemi ansamlas omogna blodceller med nedsatt fšrmŒga till utmognad och programmerad celldšd. Detta leder till frŒnvaro av normala blodceller, vilket Šr huvudorsaken till de infektioner och blšdningsrubbningar som utgšr leukemins frŠmsta symptom. Akut leukemi har hittills framfšr allt behandlats medThe terminal differentiation of leukemic cells is closely connected to their death. The concept of differentiation therapy originates from the idea that forced maturation of leukemic cells could induce cell death without the side-effects that are provoked by ordinary chemotherapy. The tumour suppressor protein p53 is a transcription factor, and can induce cell cycle arrest and apoptosis of maligna

Popular Abstract in Swedish I en komponent som utsätts för upprepande på- och avlastningar, d.v.s. cyklisk belastning, kan defekter i form av sprickor initieras och börja växa. Detta fenomen kallas utmattning och kan leda till haveri med potentiellt katastrofala följder. Det är därför viktigt att förstå fenomenen som ligger bakom utmattning och att ha tillförlitliga modeller för att förutsäga livsUnderstanding of the growth of fatigue cracks is of utmost importance since such growth often has a profound influence on the life of components subjected to cyclic loading. Thus, reliable fatigue life models enable a more efficient use of materials and improve the performance and efficiency in many applications. This thesis deals with the growth of fatigue cracks subjected to high load amplitude

Abstract in Undetermined Kapitlet bygger på en etnologisk studie av fenomenet outshopping dvs vad det innebär för en liten ort att invånarna väljer bort ortens butiker till förmån för längre bort belägna butiker. Butikerna på landsbygden slår igen en efter en beroende både på avfolkning och på förändrade inköpsmönster hos befolkningen. Studien visar på omfattningen av "butiksdöden" på landsbygden.

Background: The International Study Group for Pancreatic Surgery provides globally accepted definitions for reporting of complications after pancreatic surgery. This International Study Group for Pancreatic Surgery project aims to provide a standardized framework for reporting of the results of operative treatment for chronic pancreatitis. Methods: An International Study Group for Pancreatic Surge

The therapeutic landscape of chronic myeloid leukemia (CML) has profoundly changed over the past 7 years. Most patients with chronic phase (CP) now have a normal life expectancy. Another goal is achieving a stable deep molecular response (DMR) and discontinuing medication for treatment-free remission (TFR). The European LeukemiaNet convened an expert panel to critically evaluate and update the evi

The global financial crisis has highlighted the importance of financial factors on economic performance. Most of the existing research analyses the contemporary experience, and especially the 1980 s onwards. This paper investigates the effects of stock prices, real estate prices and debt on consumption and investment expenditures by estimating consumption and investment equations for about 110 yea

BACKGROUND/AIM: Cervical cancer is the most common cancer among women in Ethiopia. The objective was to evaluate the participation rate of a free of charge vaginal self-sample (Aptima multitest swab, Hologic) for the detection of human papillomavirus (HPV) in an Ethiopian cohort. PATIENTS AND METHODS: Specimens were collected from women employed by Ethiopian Airlines in Addis Abeba (N=5950). Sampl

In this opinion in the Dutch financial newspaper I discuss the economic rationale behind the phenomena that charities donate to companies. This is a new way in which charities try to achieve the greatest possible impact and, for example, ensure that vaccines are also developed for commercially uninteresting markets. The Dutch tax authorities are sometimes reluctant to view this as public benefit e

The relative contribution of different microbial groups to soil organic matter (SOM) turnover and utilisation of rhizodeposits during a cropping season has remained largely unknown. We used a long-term field experiment (started in 1956), in which C3 crops were replaced with C4 silage maize in 2000, to investigate dynamics of fungi and bacterial groups and their utilisation of ‘young-C4’ and ‘old-C

Background: Pediatric asthma remains a public health challenge with enormous impact worldwide. Objective: The aim of this study was to identify and prioritize unmet clinical needs in pediatric asthma, which could be used to guide future research and policy activities. Methods: We first identified unmet needs through an open-question survey administered to international experts in pediatric asthma