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Parkinson's disease (PD) is a neurodegenerative disease where the degeneration of the nigrostriatal pathway leads to specific motor deficits. There is an unmet medical need for regenerative treatments that stop or reverse disease progression. Several growth factors have been investigated in clinical trials to restore the dopaminergic nigrostriatal pathway damaged in PD. Platelet-derived growth fac
This paper has been aimed at implementing and validating a simplified environmental feedback fire model in FDS as a complement to more advanced pyrolysis models. The two main means of environmental feedback have been identified as the oxygen concentration close to the fuel base and the radiative feedback from the surrounding obstructions and smoke layer. The oxygen concentration at the fuel base h
Long-term genetic data from intensively monitored natural populations are important for understanding how effective population sizes (N e) can vary over time. We therefore genotyped 1622 common buzzard (Buteo buteo) chicks sampled over 12 consecutive years (2002-2013 inclusive) at 15 microsatellite loci. This data set allowed us to both compare single-sample with temporal approaches and explore te
In this paper, we cast the idea of antithetic sampling, widely used in standard Monte Carlo simulation, into the framework of sequential Monte Carlo methods. We propose a version of the standard auxiliary particle filter where the particles are mutated blockwise in such a way that all particles within each block are, first, offspring of a common ancestor and, second, negatively correlated conditio
A model is developed to simulate the cross-shore (CS) exchange of sand and the resulting profile response at decadal scale to be used in regional coastal evolution models. The CS model consists of modules for calculating dune erosion and overwash, wind-blown sand transport, and bar-berm material exchange. The sand transport equations included in these modules are formulated based on relevant physi
The evolution of a mechanism for attaining reproductive isolation between two diverging populations is a key step in the speciation process. We studied phenotypic variation, genetic differentiation, spatial distribution and reproductive ecology in two sympatric forms of the understorey palm Geonoma macrostachys in lowland tropical rainforest in Amazonian Ecuador. The two forms were morphologically
In order to describe partially premixed supersonic combustion numerically, G/Z flamelet model is developed and compared with finite rate model in hybrid RANS/LES simulation to study the strut-injection supersonic combustion flow field designed by the German Aerospace Center. A new temperature calculation method based on time-splitting method of total energy is introduced in G/Z flamelet model. Sim
This thesis investigates the electronic properties of a number of novel III-V materials and material combinations for transistor applications. In particular, high-κ/InAs metal-oxide-semiconductor (MOS) structures and transport properties of GaSb nanowires have been studied. III-V semiconductors are potential candidates to replace Si-based electronics due to their outstanding electron transport pro
A model developed to describe long-term cross-shore (CS) exchange of sand and resulting profile evolution at regional scale was employed to simulate the evolution at three different sites. The model consists of modules for calculating dune erosion and overwash, bar-berm material exchange, and dune build-up by wind-blown sand transport, as described in detail in a companion paper (Larson et al., 20
A one-dimensional mathematical model is presented that describes the cross-shore evolution of a long linear mound of noncohesive sediment placed in the nearshore and exposed to non-breaking waves. The equation for the transport rate accounts for wave asymmetry and gravity, and the net rate is expressed by reference to an equilibrium profile shape. Simplifications reduce the governing equation for
Three classes of membrane active peptides (MAPs) are considered in this review: cell penetrating peptides (CPPs); anti-microbial peptides (AMPs), and amyloidal peptides. We summarize both experimental and theoretical results for several representative peptides in these different classes, which highlight commonalities in their interactions with model lipid membranes. While it is clear that no fixed
Blueberry fruit fly, Rhagoletis mendax Curran (Diptera: Tephritidae), females deposit a host-marking pheromone (HMP) on the surface of fruit immediately after oviposition that deters oviposition by female conspecifics. We collected this HMP from artificial oviposition devices and faeces. In subsequent two-choice bioassays, gravid females showed a strong preference for untreated oviposition devices
The effect molecular crowding, defined as the volume exclusion exerted by one soluble inert molecule upon another soluble molecule, has on the structure and self-interaction of lipid-free apoA-I were explored. The influence of molecular crowding on lipid-free apoA-I oligomerization and internal dynamics has been analyzed using electron paramagnetic resonance (EPR) spectroscopy measurements of nitr
The differences in chromatographic behaviour of individual deoxynucleotides as well as small single-stranded and double-stranded DNA molecules have been examined for two resins from the Capto family: Capto Adhere and Capto Q ImpRes. Capto Adhere carries a multimodal ligand which combines strong anion with aromatic recognition, while Capto Q ImpRes is a strong anion exchanger with a chemically simi
Starch is a major energy source for all domains of life. Recent advances in structures of starch-degrading enzymes encompass the substrate complex of starch debranching enzyme, the function of surface binding sites in plant isoamylase, details on individual steps in the mechanism of plant disproportionating enzyme and a self-stabilised conformation of amylose accommodated in the active site of pla
