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Genome-wide study on uveal melanoma patients finds association to DNA repair gene TDP1

Uveal melanoma is a life-threatening disease for which data on germline predisposition are essentially limited to mutations in the BAP1 gene. Many risk factors are shared between uveal melanoma and cutaneous melanoma, and these include fair skin color and light eye color. We carried out a genome-wide association study on 590 uveal melanoma patients and 5199 controls. Using a P-value limit of 10 we

Characterization of Nanowire Devices Using Nano-Focused X-Ray Beams

The long absorption length of hard X-rays makes them ideal tools for investigating electronic and optoelectronic devices in realistic operational conditions. Modern X-ray optics reach the relevant length scales for single nanoelectronic devices. Here, methods to investigate single nanowire devices with nanofocused X-rays are discussed. The X-rays are used both as pump and probe of semiconductor na

Three new genera of the Ramalinaceae (lichen-forming Ascomycota) and the phenomenon of presence of ‘extraneous mycobiont DNA’ in lichen associations

Three new genera Coppinsidea, Vandenboomia and Wolseleyidea are described and the genera Ivanpisutia, Lecaniella and Myrionora are resurrected on the basis of a phylogenetic analysisof multi-locus sequence data of the Ramalinaceae including the nuclear protein-codingmarker rpb2, the internal transcribed spacer and a fragment of the small mitochondrialsubunit. The genus Hertelidea was positioned wi

Some aspects of controlling radiant and convective cooling systems

Designing appropriate control systems for radiant heating and cooling terminals entails an understanding of their dynamic behaviour. This study experimentally investigates the dynamic response of a room with convective and radiant cooling systems. The experiments were performed in a 12.6 m2 large test room outfitted as a single-office room. The main cooling system was radiant ceiling panels which

New and noteworthy lichen-forming and lichenicolous fungi 9

The new for science genus Loekoeslaszloa S. Y. Kondr. et J.-S. Hur, confirmed by three gene phylogeny of the subfamily Teloschistoideae of the Teloschistaceae based on nrITS, nrLSU and mtSSU sequences, and ten new to science species from Eastern Asia, i.e. from South Korea: Bacidina loekoesiana S. Y. Kondr. et J.-S. Hur, Fauriea jejuensis S. Y. Kondr., L. Lőkös et J.-S. Hur, Gyalecta ulleungdoensi

Repair and Reconstruction of Peripheral Nerve Injuries. Treatment with G-CSF and Stromal Vascular Fraction.

While surgery is a cornerstone in treatment of peripheral nerve injuries, it is not a comprehensive approach, and outcome is unsatisfactory, especially sensory function. The present aim was to translate recent findings about stem- and progenitor cells to improve regenerative outcome, where the cells have to be autologous, available within the same surgical procedure, and minimally manipulated. Gra