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Subjective cognitive decline (SCD) is proposed as an indicator of transitional disease stage 2 in the Alzheimer’s disease (AD) continuum. However, molecular and particularly longitudinal fluid biomarker data for this stage are still limited. This study aimed to determine whether blood-based biomarkers in amyloid-positive individuals with SCD (A + SCD) support the notion of stage 2 as a distinct st
Objective: Quality measures in healthcare are crucial for improving outcomes and ensuring patient safety. This study investigated the evolution, implementation, and impact of Primary Care Quality (PCQ). The PCQ aims to facilitate nationwide quality benchmarking, serving as a tool for quality improvement (QI) and research. Design/Settings: A descriptive design outlining the development and operatio
Introduction: Chemoradiotherapy is standard treatment for limited-stage SCLC. However, most patients relapse and there is a need for better treatment. We investigated whether twice-daily thoracic radiotherapy (TRT) of 60 Gy/40 fractions improves survival compared with the established schedule of 45 Gy/30 fractions. Here, we report final survival data and long-term toxicity. Methods: Randomized, op
Objectives: Coagulation test results may be affected by hemolysis, icterus and/or lipemia (HIL). Detailed guidelines for HIL-management are missing, both for manual and automatic HIL-checks. The aim of this survey was to provide an overview of the practical procedures for the detection and handling of HIL-samples used by laboratories in Europe in the context of coagulation testing. Methods: A Surv
Humans and animals communicate with rhythmic behaviours that vary greatly in terms of temporal parameters and patterns. In this chapter we discuss the neuromuscular architecture underlying rhythmic behaviours and address factors that constrain their rhythmic properties. In Part I of the chapter we provide background regarding the building blocks of rhythmic communication from the muscles to the br
Background and aims: The relationship between uncommon phenotypes, such as metabolically healthy obesity and normal weight with metabolic syndrome (MetS), and cardiovascular disease (CVD) risk, remains unclear. We investigated how different combinations of body mass index (BMI) and MetS are associated with overall and specific CVDs and how the number of MetS components influences CVD risk in indiv
Group Exhibition. Carlier-Gebauer. September - October 2025.Fluid Systems explores fluidity as a site of metamorphosis: a continuous, ideologic process in which gender, identity, and social constructs dissolve into transient states of becoming. Engaging with the transcendence of fixed categories, it foregrounds phenomena that resist comprehension, gesturing toward the unknown as both subject and m
Purpose: Children and youth with disabilities are at increased risk of abuse a major societal and public health problem in Cameroon. The aim was to explore the causes of abuse among children and youth with disabilities in homes and institutions in the Northwest Region of Cameroon. Methods: A qualitative study was conducted, including 50 in-depth interviews with children and youth with disabilities
Understanding the interplay between human brain structure and function is crucial to discern neural dynamics. This study explores the relation between brain structure and macroscale functional activity using subject-specific structural connectome eigenmodes, complementing prior work that focused on group-level models and geometry. Leveraging data from the Human Connectome Project, we assess accura
Mesosiderites are rare, differentiated meteorites, so-called stony-iron meteorites—they are impact breccias composed of an unusual mix of crustal basalt and pyroxenite, core-derived metal, but no mantle materials. This odd mixture makes their origin enigmatic and has inspired many different formation theories over the last several decades. Some of the outstanding questions have regarded the origin
In this work, we revisit unweighted event generation for multi-parton tree-level processes in massless QCD. We introduce a two-step approach, in which initially unweighted events are generated at leading-colour (LC) accuracy, followed by a reweighting of these events to full-colour (FC) accuracy and applying an additional unweighting cycle. This method leverages the simple structure of LC integran
BACKGROUND: This study aimed to evaluate the prevalence of pathogenic/likely pathogenic cardiomyopathy variant carriers in a multiancestry US population and examine the risk of adverse clinical outcomes. METHODS: This retrospective cohort study included multiancestry US adults aged ≥18 years with sequencing data from the All of Us Research Program. Pathogenic/likely pathogenic variants in cardiomy
Insulin secretion from vesicles within pancreatic beta cells occurs through the rapid (≤10 ms) process of exocytosis. A crucial final step in this process is the formation of a fusion pore, which connects the insulin vesicle interior to the extracellular space and insulin secretion rate. We employed real-time single-cell amperometry (SCA) with microsensors to quantitatively and dynamically monitor
Type 1 diabetes (T1D) and other autoimmune diseases (AIDs) often co-occur in families. Leveraging data from 58,284 family trios in Finnish nationwide registers (FinRegistry), we identified that, of 50 parental AIDs examined, 15 were associated with an increased T1D risk in offspring. These identified epidemiological associations were further assessed in 470,000 genotyped Finns from the FinnGen stu
BACKGROUND: The risk of infection-related death is high in patients undergoing dialysis. This study aimed to identify the modifiable risk factors for PD-related infections in patients undergoing peritoneal dialysis.METHODS: This was a population-based retrospective cohort study conducted in Skåne, South Sweden, which included all patients receiving peritoneal dialysis (PD) between 2011 and 2020. T
This research explores the politics of publics to understand consumer resistance to sportswashing on digital platforms. Drawing on Mouffe’s agonistic pluralism and Latour’s matters-of-concern, we analyze Twitter data to unveil how consumers navigate moral quandaries, sleepy resistance, and polarizing re-action. The study contributes to knowledge on publics and macro-level resistance.
An abnormal blood pressure (BP) response on standing is associated with atherosclerotic cardiovascular disease (CVD). The role of physical activity (PA) on orthostatic BP-reactions and its relation to subclinical atherosclerosis is unclear. We aimed to assess the association between PA and orthostatic BP-reactions, and whether PA modifies the relationship between orthostatic BP-reactions and subcl
