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The innovation systems framework enables a view of innovation as a process involving different actors in different constellations, but it has nonetheless most often been paired with quantitatively oriented studies of patents, licences and spin-offs. In this article, the authors use two cases of technological innovation at an academically organized but user-oriented research facility for experiment
This article chronicles the most recent history of the Deutsches Elektronen-Synchrotron (DESY) located in Hamburg, Germany, with particular emphasis on how this national laboratory founded for accelerator-based particle physics shifted its research program toward multi-disciplinary photon science. Synchrotron radiation became DESY’s central experimental research program through a series of changesThis article chronicles the most recent history of the Deutsches Elektronen-Synchrotron (DESY) located in Hamburg, Germany, with particular emphasis on how this national laboratory founded for accelerator-based particle physics shifted its research program toward multi-disciplinary photon science. Synchrotron radiation became DESY’s central experimental research program through a series of changes
Hematological malignancies are defined by their underlying genetic alterations, many of which are used to diagnose patients to classify them to different risk groups that dictate the therapy given. Recent advances in high-throughput sequencing have highlighted the presence of co-occurring genetic lesions and that they may form distinct genetic clones that evolve throughout disease progression. Acu
The use of fossil resources must be phased out during the next few decades in order to meet the adopted 2° target. The transition to non-fossil feedstocks in the production of chemicals and transportation fuels will make it increasingly important to economise on the biomass carbon since biomass is a limited resource. Carbon dioxide (CO2) can be used as carbon feedstock and thus serve as a valuable
Changes to the contemporary food system, including meals and eating patterns, have occurred quickly. One such change over the past 30 years has been the increase of commercially produced foods aimed at food allergies and intolerances and ‘free from’ dieting. The gluten free diet has recently emerged as a popular diet trend in Western countries, outpacing its origins as a treatment for celiac disea
Cellobiose dehydrogenase (CDH) is a versatile bioelectrocatalyst lately at focus due to its sugar oxidising properties in combination with its inherent ability for direct electron transfer communication with electrodes making it possible to be used in bioanodes in the enzymatic fuel cells (EFCs), self-powered biosensors, and biosupercapacitors. During the last 20 years, many new nanomaterials and
The Amazon rainforest is disproportionately important for global carbon storage and biodiversity. The system couples the atmosphere and land, with moist forest that depends on convection to sustain gross primary productivity and growth. Earth system models that estimate future climate and vegetation show little agreement in Amazon simulations. Here we show that biases in internally generated clima
Purpose The purpose of this study was to illuminate how men under 65 years of age experience their everyday Life one year or more after a radical prostatectomy for localised prostate cancer. Method Interviews with 19 men aged under 65 were performed 12–18 months after their radical prostatectomy. The interviews were analysed using a thematic content analysis. Results The analysis of the interviews
Small wintering passerines adaptively modulate daily body mass acquisition as part of their energy management policy. However, whether birds optimize overnight mass loss or body mass at dawn remains poorly understood. We studied environmental correlates of individual variation in body mass at dusk, overnight mass loss and body mass at dawn in a wild population of Great Tits Parus major wintering i
Northern European peatlands are important habitats for biological conservation because they support rich biodiversity and unique species compositions. However, historical management of peatland habitats has had negative consequences for biodiversity and their degradation remains a major conservation concern. Despite increasing awareness of the conservation value of peatlands, the statuses and ecol
Estimation of high-resolution terrestrial evapotranspiration (ET) from Landsat data is important in many climatic, hydrologic, and agricultural applications, as it can help bridging the gap between existing coarse-resolution ET products and point-based field measurements. However, there is large uncertainty among existing ET products from Landsat that limit their application. This study presents a
Over the last decade we have witnessed an unprecedented growth in the number of cross-border R&D investments towards large emerging countries such as China and India. However, small middle-income countries have played a marginal role as recipients of R&D-related FDI despite increasing policy efforts. In particular, several Latin American countries have recently launched new policy programs
Ultrafast fluorescence spectroscopy was used to investigate the hole injection in CdxSeyZn1-xS1-y gradient core-shell quantum dot (CSQD) sensitized p-type NiO photocathodes. A series of CSQDs with a wide range of shell thicknesses was studied. Complementary photoelectrochemical cell measurements were carried out to confirm that the hole injection from the active core through the gradient shell to
In the last decade, we have witnessed an unprecedented growth in the globalisation of innovation activities and more specifically, of global innovation networks (GINs) extending into middle-income countries. However, hitherto most of the literature is either theoretical or based on a handful of cases. We do not know what are the different forms of openness through networks in which firms participa
Nitrogenase is the only enzyme that can break the triple bond in N2 to form two molecules of ammonia. The enzyme has been thoroughly studied with both experimental and computational methods, but there is still no consensus regarding the atomic details of the reaction mechanism. In the most common form, the active site is a MoFe7S9C(homocitrate) cluster. The homocitrate ligand contains one alcohol
We have studied the binding of 102 ligands to the farnesoid X receptor within the D3R Grand Challenge 2016 blind-prediction competition. First, we employed docking with five different docking software and scoring functions. The selected docked poses gave an average root-mean-squared deviation of 4.2 Å. Consensus scoring gave decent results with a Kendall’s τ of 0.26 ± 0.06 and a Spearman’s ρ of 0.
A metric analysis on hulled barley grain from the Iron Age regional centre of Uppåkra and surrounding sites in southern Sweden has identified a variation in the size of the grain found on these archaeological sites. Large, high-quality grain was found more frequently at Uppåkra when compared to sites in the surrounding area, where smaller grain was more frequent. The observed large grain found at
