BACKGROUND: Apolipoprotein M (ApoM) is associated with lower mortality in heart failure (HF) patients and protects against cardiac and kidney injury in mice.OBJECTIVES: The authors investigated dapagliflozin's cardiorenal effects by studying its association with ApoM in patients with HF with reduced ejection fraction.METHODS: We performed a secondary analysis of DEFINE-HF (Dapagliflozin Effects on

INTRODUCTION: Trust in healthcare is central to the delivery of care and unequally distributed between groups in society. Experiences of perceived discrimination have been associated with lack of such trust. Although the importance of trust in healthcare has been highlighted in recent years, studies in this area are relatively scarce.MATERIALS AND METHODS: We investigated the risk of low trust in

Background: Inhibitory deficits are common in psychopathology. Emotion-related impulsivity (ERI) and rumination are general risk factors for psychiatric distress that are similarly associated with dysfunctional inhibition—particularly in affective contexts. A number of cognitive remediation procedures have been developed to improve inhibitory control; however, most remediation programs focus on “c

Dopamine replacement therapy for Parkinson's disease can induce impulsive-compulsive behaviours (ICBs). Here we compare the D2/3 agonist ropinirole and L-DOPA, given alone or combined, with regard to their potential to induce ICBs in rats sustaining bilateral striatal injections of 6-hydroxydopamine. Daily treatment with ropinirole (2.5 mg/kg), L-DOPA (24.0 mg/kg), or their combination was given f

Introduction: Acinetobacter baumannii is a gram-negative opportunistic bacterium that causes life-threatening infections in immunocompromised hosts. The complement system is a critical mechanism of innate immunity that protects the human body from bacterial infections. Complement activation leads to the deposition of the membrane attack complex (MAC), which can directly lyse gramnegative bacteria.

Background: Atrial fibrillation (AF) is the most common arrhythmia worldwide and the majority of AF patients are treated in primary care. In order to minimize hospitalizations and visits to emergency departments, nurse-led care was introduced in secondary care and primary health care (PHC). However, even though nurse-led care was initiated in PHC almost a decade ago, and ESC guidelines recommended

Background: Human milk offers significant health benefits for infants; however, when not feasible, infant formula serves as an alternative. The higher protein content in infant formula is thought to contribute to the distinct metabolic profiles observed in formula-fed infants compared with those fed human milk. Objectives: This study investigates the impact of formula protein quantity and whey pro

Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease. Several studies have identified transcriptional subtypes of mCRPC, but comprehensive analysis of prognostic gene expression pathways has been limited. Therefore, we aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression-based pathways with clinical out

We have calculated redox potentials of 12 blue copper protein sites comparing 64 computational methods, systematically varying the quantum mechanics (QM) system size, dielectric constants, density functional, and basis sets. All methods were based on structures optimized with combined QM and molecular mechanics (QM/MM) approaches. The redox potentials were evaluated using 10 quality metrics. The b

To reverse biodiversity loss, creating resilient ecological networks has been promoted in policy and practice. However, we argue that emphasising networks within policy without clear conservation prioritisations may direct focus away from ecological processes important for population persistence. We studied the rationale for resilient ecological networks represented in a policy context, by reviewi

Aims: This study surveyed individuals and caregivers of children who received teplizumab at stage 2 type 1 diabetes (T1D) to garner real-world experiences and their health outlook for the future following treatment with the first approved disease-modifying immune therapy for delaying the onset of Stage 3 T1D. Materials and Methods: This was a cross-sectional, observational, online survey (conducte

Background: Survivors of stroke commonly report sleep disturbances. Studies of sleep disturbances after stroke are mostly performed in the acute phase. An increased knowledge of sleep disturbances and its determinants a longer time after stroke is needed to improve treatment and rehabilitation. Objective: To assess survivors of stroke more than 1 year after stroke onset and (1) investigate self-re

The quantum prepare-and-measure scenario has been studied under various physical assumptions on the emitted states. Here, we first discuss how different assumptions are conceptually and formally related. We then identify one that can serve as a relaxation of all others, corresponding to a limitation on the one-shot accessible information of the state ensemble. This motivates us to study the optima

The road freight sector’s significant contribution to greenhouse gas emissions necessitates emission mitigating strategies to meet climate targets, such as the Paris Agreement’s goal of 43% emission reduction. While Battery Electric Trucks (BETs) show great potential to reach these goals, their successful integration hinges on optimization and route planning. This thesis investigates the condition

In order to solve planetary health, the human-nature relationship has to be understood in more detail. Therefore, the current study aimed to validate and assess construct, convergent, divergent, and predictive validity of the Nature Disconnectedness Scale. Using data from 312 participants in Sweden, confirmatory factor analyses found support for a structure consisting of three dimensions and eight

This study investigates the effectiveness of an interactive module compared to an e-brochure designed to market a video analytics technology. The interactive module was developed using the same core content as the e-brochure, allowing for a direct comparison of format effects. The primary focus of the study is to evaluate how the interactive module impacts user engagement across cognitive, behavio

The most well researched associative memory illusion (AMI) is the Deese–Roediger–McDermott (DRM) paradigm: a list learning task found to induce false memories though study lists with associated words. Typically, the study lists are composed of the 12—15 most frequent Kent-Rosanoff word-pair associations of a "critical lure". This thesis attempts a different approach to list generation.

I det svenska samhället syns en nedåtgående trend när det gäller barn och ungas läs- och skrivförmåga. Därmed finns det ett värde i att utforska effekter av läsfrämjande initiativ. Den aktuella studien ämnar således att studera vilken betydelse miljön på kulturhuset Funnys Äventyr kan ha i relation till högläsning. Mer specifikt undersöks vilken betydelse miljön har för barns nivå av distraktion o

This thesis examines how insights from cognitive science can inform the design of self-study training materials to reduce cognitive load and enhance sales onboarding in complex technical domains. The study was conducted at a global company specializing in industrial sensor solutions, focusing on machine vision sales training. The study was conducted in three phases. First, a pre-study mapped the