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Genome-wide association studies (GWASs) have identified several, mainly co-dominantly acting, single-nucleotide polymorphisms (SNPs) associated with Hodgkin lymphoma (HL). We searched for recessively acting disease loci by performing an analysis of runs of homozygosity (ROH) based on windows of homozygous SNP-blocks and by calculating genomic inbreeding coefficients on a SNP-wise basis. We used da
The main objective was to locate QTL and estimate the proportion of total genetic variance attributable to quantitative trait loci (QTL) for production index traits and the udder health index identified on six Bos taurus autosomes in the Danish Holstein dairy cattle population. Data were obtained from a granddaughter design of 20 sire families with a total of 1 869 progeny tested sons. The number
Critical debates within the science of (social) epidemiology concern the relative lackof social theory in epidemiological research and the low discriminatory accuracy (DA)of much epidemiological knowledge on factors and markers of risk for disease.Against this background, this thesis integrates intersectionality theory intoepidemiological study. The purposes are to improve the understanding ofhete
In this study, the impact of various traits and effects on auction price of Texel, Suffolk and German white-headed mutton rams was determined. Furthermore, (co)variance components between auction price and performance traits recorded at licensing were estimated. Data from 1988 to 2007 were extracted from the recording database of the Sheep Breeding Organisation in Schleswig-Holstein, Germany. Auct
A granddaughter design with 10 grandsires was simulated to investigate different types of measurements of performance traits in marker assisted breeding evaluation (MA-BE). Genetic and phenotypic data were simulated for all grandsires, granddams and 500 sires. For each of the 100 replicates of the simulation the gametic relationship matrix was computed for one position and a MA-BE was performed to
Building on the works of James J. Helm, I argue that it is both fruitful and plausible to read Aeschylus’s Oresteia as expounding a coherent moral outlook. Going beyond Helm, I offer a reading of the trilogy as incorporating a system of deontic requirements that amounts to a kind of noncodi able ethical pluralism that does not fall prey to any blatant self-contradictions and that can be interprete
Aims: Impact of changes of treatments on outcomes in ST-elevation myocardial infarction (STEMI) patients in real-life health care has not been documented.Methods and results: All STEMI cases (n = 105.674) registered in the nation-wide SWEDEHEART registry between 1995 and 2014 were included and followed for fatal and non-fatal outcomes for up to 20 years. Most changes in treatment and outcomes occu
Background: Carbohydrate antigen 125 (CA125) is a mucin produced by serosal cells in response to mechanical and inflammatory stimuli. CA125 has emerged as prognostic biomarker in heart failure (HF) and correlates with markers of fluid overload, echocardiographic parameters and prognosis in HF patients. In patients with acute coronary syndrome (ACS), elevated CA125 is correlated with a higher risk
Background: Galectin 3 and ST2 are mediators and biomarkers of myocardial fibrosis and remodeling that have recently entered the clinical practice guidelines as prognostic factors in heart failure patients. Elevated galectin 3 and ST2 levels in acute myocardial infarction patients have also been associated with increased incidence of adverse events during follow-up. Purpose: We aimed to assess the
Young adults have largely been absent in previous research on consequences of high sex ratios in China and few studies have zoomed in on those belonging to the higher strata of the population. With the purpose of contributing to filling this gap, this study investigates what implications sex ratio imbalance has for mate selection strategies and practices among young adults aged 19–24 in higher edu
With the proliferation and application of democratic innovations around the world, the empirical study of deliberative and participatory processes has shifted from small-scale environments and experiments to real-lifepolitical processes on a large scale. With this shift, there is also a need to explore new theoretical approaches in order to understand current developments. Instead of analyzing dem
While pure deliberation has still not been found online, the field of online deliberation research is blossoming. Born out of the “frustrations and possibilities” of the 1990s, a current theme in the field is to re-link deliberative theory with empirical political science. The aim of this systematic literature review is to sort out and examine important features of this development; to identify an
This chapter describes the background for, and implementation of, the Barnahus model within the Nordic countries. It highlights the core elements of the model and the specifics of the Nordic welfare state context relating to the child welfare and criminal justice systems. A contextual and comparative perspective is used to shed light on how the model is shaped by the legal and institutional contexThis chapter describes the background for, and implementation of, the Barnahus model within the Nordic countries. It highlights the core elements of the model and the specifics of the Nordic welfare state context relating to the child welfare and criminal justice systems. A contextual and comparative perspective is used to shed light on how the model is shaped by the legal and institutional contex
