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BackgroundKetamine has emerged as a fast-acting and powerful antidepressant, but no head to head trial has been performed, Here, ketamine is compared with electroconvulsive therapy (ECT), the most effective therapy for depression.MethodsHospitalized patients with unipolar depression were randomized (1:1) to thrice-weekly racemic ketamine (0.5 mg/kg) infusions or ECT in a parallel, open-label, non-

A key parameter for the low-temperature magnetic coupling of in dinuclear lanthanide single-molecule magnets (SMMs) is the barrier UFA resulting from the exchange and dipole interactions between the two 4f moments. Here we extend the pseudospin model previously used to describe the ground state of dinuclear endofullerenes to account for variations in the orientation of the single-ion anisotropy ax

Although an increasing number of studies are combining skeletal and neural morphology data in a phylogenetic context, most studies do not include extinct taxa due to the rarity of preserved endocasts. The early Eocene avifauna of the Fur Formation of Denmark presents an excellent opportunity for further study of extinct osteological and endocranial morphology as fossils are often exceptionally pre

The tremendous phenomenological success of the Standard Model (SM) suggests that its flavor structure and gauge interactions may not be arbitrary but should have a fundamental first-principle explanation. In this work, we explore how the basic distinctive properties of the SM dynamically emerge from a unified New Physics framework tying together both flavor physics and Grand Unified Theory (GUT) c

MADS‐box transcription factors are crucial regulators of inflorescence and flower development in plants. Therefore, the recent interest in this family has received much attention in plant breeding programs due to their impact on plant development and inflorescence architecture. The aim of this study was to investigate the role of HvMADS‐box genes in lateral spikelet development in barley (Hordeum

Agricultural output fluctuated worldwide after the emancipation of slaves. The usual explanation is that former slaveholders now lacked labor. This is not the full story: slaves were not just laborers but capital investments to support production. Using databases covering more than 40 years from Stellenbosch in the British Cape Colony, this study measures changes in output before and after emancip

Entangled logics, which attribute meaning to security, characterise the contemporary security field, bringing about broad comprehensions and ambiguous concepts. Civil defence has (re)surfaced as one such concept that is broadly conceived in the official discourses produced by decision-makers. Since security is ultimately enacted by practitioners, alias decision-takers, their interpretations of con

Development economics has long focused on growth patterns to explain countries’ ability to catch up and forge ahead. We argue, however, that resilience to economic shrinking matters more. Using the examples of Brazil and Indonesia, we propose that a framework consisting of social capabilities – namely structural transformation, autonomy, and inclusion – can explain why Indonesia is more resilient

Background: The fractional exhaled nitric oxide (FENO) test is a point-of-care test that is used in the assessment of asthma. Objective: To provide evidence-based clinical guidance on whether FENO testing is indicated to optimize asthma treatment in patients with asthma in whom treatment is being considered. Methods: An international, multidisciplinary panel of experts was convened to form a conse

Att fastställa byggnaders energiprestanda på ett rättvist och transparent sätt är viktigt.För att kunna fastställa en byggnads energiprestanda i drift och för att identifieraprestandaavvikelser behöver uppmätt energianvändning normaliseras. Detta görs genom att korrigera uppmätt energianvändning för avvikelser som förelegat vid mätning jämfört med de förutsättningar som antagits vid projektering.I

This comparative study explores how breaches can be applied to unveil potential blindspots within the social constructs surrounding design practice in Sweden and New Zealand. When in-depth interviews with designers in both countries were analysed, similarities and differences appeared. The underlying norms and values identified suggest that the two countries share a similar value-base in relation This comparative study explores how breaches can be applied to unveil potential blindspots within the social constructs surrounding design practice in Sweden and New Zealand. When in-depth interviews with designers in both countries were analysed, similarities and differences appeared. The underlying norms and values identified suggest that the two countries share a similar value-base in relation

In this article, we explore why solidarity has not worked according to expectation in EU migration and asylum law, and why it is unlikely to work in the future. First, we explore discourses of burden-sharing and solidarity in EU law from the 1990s up to the Lisbon treaty in 2009 to identify emergent path dependencies. This period saw the introduction of primary law provisions on solidarity, such a

OBJECTIVE: In Huntington's disease (HD), the disease-causing huntingtin (HTT) protein is ubiquitously expressed and causes both central and peripheral pathology. In clinical HD, a higher body mass index has been associated with slower disease progression, indicating that metabolic changes may be involved in disease pathogenesis. Underlying mechanisms of metabolic changes in HD are not fully known,