Objectives: North Sea–Progressive Myoclonus Epilepsy (NS-PME) is a rare, childhood-onset disorder primarily characterized by movement disorders including progressive myoclonus and ataxia; subsequently accompanied by varying degrees of epilepsy. While motor symptoms are clearly defined, quality of life (QoL) has never been investigated in NS-PME. Additionally, nonmotor symptoms (NMS) including anxi

There is a need for ground-breaking technologies to boost crop yield, both grains and biomass, and their processing into economically competitive materials. Novel cereals with enhanced photosynthesis and assimilation of greenhouse gasses, such as carbon dioxide and ozone, and tailored straw suitable for industrial manufacturing, open a new perspective for the circular economy. Here we describe the

Manufacturing activities are highly prioritized by many low- and middle-income countries in the twentyfirst century, yet there is an urgent need for these processes to be done in a way that bring about sustainable and inclusive development. As an African forerunner that has developed manufacturing, achieved sustained growth, and undergone structural transformation, Mauritius is an interesting case

Chapter 7, written by Vera Sadovska, Oksana Mont and Yuliya Voytenko Palgan, explores the economic sustainability of food-sharing initiatives (FSIs). Bringing together insights from a systematic literature review and empirical research in Barcelona, the chapter examines the economic challenges FSIs face, such as managing operational costs, obtaining funding and dealing with regulatory complexities

The silicon isotope composition (δ30Si) of biogenic silica is often used as an archive of past environmental conditions. For example, sponge spicule δ30Si is known to be related to seawater-dissolved Si concentrations. Such a proxy application requires that the δ30Si is not diagenetically altered—or at least that any alteration can be identified and accounted for. Yet the preservation of pristine

Objective To assess patient's self-reported global assessment of health (PGA) in relation to inflammation, pain and disability in patients with rheumatoid arthritis (RA). Methods Data were obtained from the Better Anti-Rheumatic PharmacOTherapy early RA cohort, in which patients were scheduled for follow-up of 15 years. Longitudinal PGA trajectories were identified using hierarchical agglomerative

Sialinsyra är ett samlingsnamn för enkla sockerarter som har en ryggrad bestående av 9 kol, med bland annat en karboxylsyra och en glycerolsvans. Sialinsyra förekommer naturligt i kroppen hos däggdjur. Hos människan är Neu5Ac den mest förekommande sialinsyran, och när man refererar ospecifikt till sialinsyra brukar det vara Neu5Ac som avses. Neu5Ac går att hitta i änden av de kolhydratkedjor som Sialic acids are a family of 9-carbon sugars which contain a carboxyl group and a glycerol chain. Neu5Ac is the most common sialic acid in humans and occurs at the terminal position of glycoconjugates covering the cell surface. Neu5Ac is involved in several different processes in the human body and plays an important role in several physiological conditions and pathogenic diseases. Sialic acid is

Background: Prostate cancer therapy with surgical or chemical castration with gonadotropin-releasing hormone (GnRH) agonists has been linked to elevated follicle-stimulating hormone (FSH) levels, which may contribute to secondary health disorders, including atherosclerosis and diabetes. Although recent findings suggest a role for FSH beyond the reproductive system, its metabolic impact remains unc

The precuneus is a site of early amyloid-beta (Aβ) accumulation. Previous cross-sectional studies reported increased precuneus fMRI activity in older adults with mild cognitive deficits or elevated Aβ. However, longitudinal studies in early Alzheimer’s disease (AD) are lacking and the relationship to the Apolipoprotein-E (APOE) genotype is unclear. Investigating the PREVENT-AD dataset, we assessed

The age-specific incidence of traumatic brain injury in older adults is rising in high-income countries, mainly due to an increase in the incidence of falls. The severity of traumatic brain injury in older adults can be underestimated because of a delay in the development of mass effect and symptoms of intracranial haemorrhage. Management and rehabilitation in older adults must consider comorbidit

Power converters of DC-DC nature are pivotal to supplying power in electronics, charging equipment, and renewable energy integration along with AC-DC converters. They are frequently used in most of the power supplies of electronic devices as well as dedicated high-energy functionalities including charging battery cells, electroplating, and welding. Furthermore, DC-DC switching regulators not only

Aim: The aim of this study was to explore the role of managers and employees with an assigned responsibility (i.e. inspirers) when integrating recovery-enhancing activities into everyday work in a primary health care setting. Background: The possibility of recovery during the workday is essential for employee wellbeing. However, the literature on workplace interventions focusing on recovery is sca

Objective To compare work loss after starting tumour necrosis factor inhibitors (TNFi), rituximab, abatacept or tocilizumab in patients with rheumatoid arthritis (RA). Methods We used data from the Swedish Rheumatology Quality Register to identify patients aged 19-62 years who were treated with TNFi (n=15 093), rituximab (n=2123), abatacept (n=1877) or tocilizumab (n=1720) between 2007 and 2020. D

Converters of AC-DC nature are pivotal to supplying power in electronics, charging equipment, and renewable energy integration. A closed-loop Cuk converter with switched capacitor network and PID controller was proposed in this paper to mitigate the limitations of open circuit Cuk converter topology to ensure improved power factor from input along with low distortion in output, making it ideal for