The objective of this article was to assess the cost-effectiveness of screening strategies for cardiovascular diseases (CVD). A decision analytic model was constructed to estimate the costs and benefits of one-off screening strategies differentiated by screening age, sex and the threshold for initiating statin therapy (“uniform” or “age-adjusted”) from the Spanish NHS perspective. The age-adjusted

Swedish universities and colleges have received a substantial funding increase since the turn of the millennium, as part of continued policies of expanding the admission of students to higher education to broader layers of the population and strengthen Swedish public research and development to increase the competitiveness of the Swedish knowledge-based economy. In this article, publicly available

Introduction: As people with haemophilia (PWH) receive better treatment and live longer they are more likely to encounter cardiovascular disease (CVD) and other comorbidities. ESC guidelines for the acute management of patients presenting with acute coronary syndrome (ACS) are based on the non-haemophilia population. Aim: To review the guidelines and propose relevant adaptations for PWHA without i

Several types of Galactic sources, like magnetars, microquasars, novae or pulsar wind nebulae flares, display transient emission in the X-ray band. Some of these sources have also shown emission at MeV-GeV energies. However, none of these Galactic transients have ever been detected in the very-high-energy (VHE; E>100 GeV) regime by any Imaging Air Cherenkov Telescope (IACT). The Galactic Transient

The relative importance of adaptation and individual ontogenetic experience in dogs’ high levels of behavioral compatibility with humans has been a topic of intense scientific attention over the past two decades. Salomons et al. Current Biology, 31, 3137–3144, (2021) recently presented a particularly rich data set of observations on both wolf and dog puppies that has the potential to contribute su

Objective: The decline in suicide rates has leveled off in many countries during the last decade, suggesting that new interventions are needed in the work with suicide prevention. Learnings from investigations of suicide should contribute to the development of these new interventions. However, reviews of investigations have indicated that few new lessons have been learned. To be an effective tool,

At very high energies (VHE), the emission of γ rays is dominated by discrete sources. Due to the limited resolution and sensitivity of current-generation instruments, only a small fraction of the total Galactic population of VHE γ-ray sources has been detected significantly. The larger part of the population can be expected to contribute as a diffuse signal alongside emission originating from prop

We consider the calculations of photoionization spectra and core resonances of open-shell systems using range-separated time-dependent density-functional theory. Specifically, we use the time-dependent range-separated hybrid (TDRSH) scheme, combining a long-range Hartree-Fock exchange potential and kernel with a short-range potential and kernel from a local density-functional approximation, and th

PURPOSE: We constructed Bladder Cancer Data Base Sweden (BladderBaSe) 2.0 to expand studies in BladderBaSe on incidence, treatment outcomes, side effects, survival and health economic aspects of men and women with cancer in the urinary bladder, upper tract urothelial carcinoma (UTUC) (renal pelvis and ureter) and urethral carcinoma. PARTICIPANTS: BladderBaSe 2.0 includes 53 298 patients with cance

Mantle cell lymphoma (MCL) after relapse is associated with poor prognosis. No standard of care exists and available evidence for treatments is limited, particularly in patients who fail Bruton tyrosine kinase inhibitor (BTKi) therapy. This multicentre retrospective chart review study, SCHOLAR-2, addresses this knowledge gap and reports on data collected from 240 patients with relapsed/refractory

The various existing measures to quantify upper limb use from wrist-worn inertial measurement units can be grouped into three categories: 1) Thresholded activity counting, 2) Gross movement score and 3) machine learning. However, there is currently no direct comparison of all these measures on a single dataset. While machine learning is a promising approach to detecting upper limb use, there is cu

Local or traditional agri-food systems in the Andes depend on community land use planning to maintain the genetic pool of crops and landraces in the face of disease, disasters, and climate change. These systems are managed integrally and on the basis of traditional knowledge around soil conservation, water management and maintaining biodiversity. At the same time, agri-food system research, policy

Hydroxyapatite (HA) has been widely used as a bone substitute and more recently as a carrier for local delivery of bone targeted drugs. Majority of the approved HA based biomaterials and drug carriers comprise of micrometer sized particulate HA (mHA) or granules and can therefore only be used for extracellular drug release. This shortcoming could be overcome with the use of cell penetrating HA nan

Subgap states are responsible for the low-bias transport features of hybrid superconducting-semiconducting devices. Here we analyze the local and nonlocal differential conductance of Coulomb-blockaded multiterminal superconducting islands that host subgap states with different spatial structures. The emerging patterns of their transport spectroscopy are used to characterize the possible topologica

We performed angle-resolved photoemission spectroscopy (ARPES) experiments on an electron-doped Sr2RhO4 system Sr2-xCexRhO4 in order to investigate the electron doping-induced metal-insulator transition (MIT). We establish the universality of MIT in electron-doped Sr2RhO4 by comparing results from Sr2-xLaxRhO4 and Sr2-xCexRhO4. Via a systematic analysis of doping-dependent transport and ARPES data

Obtaining an accurate theoretical description of the emergent phenomena in oxide heterostructures is a major challenge. Recently, intriguing paramagnetic spin and pinned orbital moments have been discovered by x-ray magnetic circular dichroism measurements at the Cu L2,3 edge of a tetragonal CuO/SrTiO3 heterostructure. Using first-principles calculations, we propose a scenario that explains both t

As temperatures decrease in autumn, vegetation of temperate and boreal ecosystems increases its tolerance to freezing. This process, known as hardening, results in a set of physiological changes at the molecular level that initiate modifications of cell membrane composition and the synthesis of anti-freeze proteins. Together with the freezing of extracellular water, anti-freeze proteins reduce pla

Millimeter-wave (mmWave) is one key enabler for high data rates in (beyond-)5G wireless communication networks. The use of directive beams and the shorter transmission range in mmWave communications make it easily obstructed or blocked by humans in dynamic real-world scenarios. Connectivity diversity, a solution to link disruption and blockage, could be achieved by deploying distributed multi-poin

The MAM blood group system (International Society of Blood Transfusion [ISBT] 041) consists of one high-prevalence antigen to date, first detected in a 31-year-old woman during her third pregnancy. Epithelial membrane protein 3 (EMP3) was recently identified as the gene coding the MAM antigen. Six unique genetic variants have been described in EMP3 in 11 MAM- individuals. EMP3 is an 18-kDa glycopr