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Proteomics education, an important challenge for the scientific community: Report on the activities of the EuPA education committee

The main missions of the EuPA Education Committee (EuPA-EC) are to promote and enhance the quality of proteomics knowledge by creating educational programs and to initiate European-wide scientific exchange programs for young proteomics researchers. In this first report we present the initial actions we have undertaken in relation to the missions of the EuPA-EC, and the educational activities that

The evolutionary history of the common chloroplast genome of Arabidopsis thaliana and A. suecica.

The evolutionary history of the common chloroplast (cp) genome of the allotetraploid Arabidopsis suecica and its maternal parent A. thaliana was investigated by sequencing 50 fragments of cpDNA, resulting in 98 polymorphic sites. The variation in the A. suecica sample was small, in contrast to that of the A. thaliana sample. The time to the most recent common ancestor (T-MRCA) of the A. suecica cp

Magnetic starch microspheres, efficacy and elimination. A new organ-specific contrast agent for magnetic resonance imaging

A new particulate magnetic resonance (MR) contrast agent was prepared by controlled precipitation of iron oxide in an aqueous starch solution. The potential of the magnetic starch microspheres (MSM) as a hepatosplenic contrast enhancer was studied by MR spectroscopy and MR imaging. Intravascular administration of MSM to rodents showed an effective blood clearance and a tissue-specific localization

A constitutive endogenous osteopontin production is important for macrophage function and differentiation.

Macrophages are involved in the pathological process underlying atherosclerosis and constitutively express the multifunctional protein osteopontin which has important exogenous effects on these cells. However, the effect of the endogenous osteopontin expression on macrophage function has been sparsely studied. To shed light on the importance of the endogenous osteopontin expression, RAW 264.7 macr

An expeditious, multi-gram isolation protocol for the ultrapotent SERCA inhibitor thapsigargin

A streamlined strategy was developed to obtain a mixture of thapsigargins from the fruits of Thapsia garganica L. The mixture was resolved by RP-silica gel flash chromatography to provide, after trituration with ether, 0.32% thapsigargin (la) as a white powder. A novel, complex phenylpropanoid (neohelmanthicin D, 2a) was also obtained, and its structure confirmed by semisynthesis.

Spontaneous magnetism of quantum dot lattices

The magnetism of square lattices of quantum dots with up to 12 electrons per dot is studied using the spin-density functional formalism. At small values of the lattice constant, all lattices are nonmagnetic and gapless. When the lattice constant is increased, the shell structure of the single dots governs the magnetism of the lattice. At closed shells, the lattices are nonmagnetic and have a gap a

Induced hypothermia in critical respiratory failure after lung transplantation

Primary graft failure after lung transplantation is a serious complication with high mortality. We present 2 cases of critical respiratory failure after lung transplantation treated with surface cooling to 32 degrees and 35 degrees C, respectively, as an adjunct to conventional intensive care. Both patients were discharged from the hospital in good clinical condition. Surface cooling may be an eff

Ambiguous framings of political consumerism: means or end, product or process orientation?

For dealing with various societal problems, 'political'/'ethical'/'responsible' consumerism is often discussed as an effective democratic and participatory tool. However, political consumerism – along with its tools, such as product labelling – is often conceived and discussed in oversimplified ways. Instead, the tension between scientific complexity, knowledge uncertainty and a codified, standard

Simultaneous detection of L-glutamate and nitric oxide from adherently growing cells at known distance using disk shaped dual electrodes

An ex vivo system for simultaneous detection of nitric oxide (NO) and L-glutamate using integrated dual 250 gin platinum disk electrodes modified individually with suitable sensing chemistries has been developed. One of the sensors was coated with an electrocatalytic layer of Ni tetrasulfonate phthalocyanine tetrasodium salt (Ni-TSPe) covered by second layer of Nation, which stabilises on the one

Modeling large deformable mirrors

Planned Extremely Large Telescopes will rely oil availability of large Deformable Mirror in the 2-3m class. Design and construction of such mirrors are challenging and call for powerful simulation tools. We present an evaluation model which is used to study performance of a large deformable mirror for three: actuator topologies. Back sensors topologies are discussed from the point of view of senso

Resisting resistance: Counter-resistance, consent and compliance in a consultancy firm

Consent, obedience and resistance can be seen as key concerns in management and organization. Why people comply is a crucial issue in the field. We address the theme within a specific area: management consultants in a big firm that places quite a lot of pressure on its personnel to be hardworking and predictable and to subordinate themselves to hierarchy, standards and tight production schedules.

Maskinisk darwinism: teknikens naturhistoria hos Samuel Butler och Gilles Deleuze

This paper provides perspectives on the development of an idea of the machine as a living being in the 20th century by looking at the relationship between the writings of Samuel Butler and Gilles Deleuze concerning the evolution of machines as an extension of—and in competition with—the human organism. Ultimately, Butler and Deleuze both describe a mechanical or “machinic" vitalism and evolutionis

Persistent organic pollutants (POP) in a benthic omnivore - A comparison between lake and stream crayfish populations

We investigated the accumulation of PCB and DDT in crayfish populations in 10 streams in southern Sweden. The results were compared with an earlier study on crayfish in lakes from the same area. We found that the concentration of pollutants in crayfish did not differ between the two types of systems. Variation in body burden was higher in stream living crayfish probably because of the higher influ

Anderson localization of a weakly interacting one-dimensional Bose gas

We consider the phase coherent transport of a quasi-one-dimensional beam of Bose-Einstein condensed particles through a disordered potential of length L. Among the possible different types of flow we identified [T. Paul, P. Schlagheck, P. Leboeuf, and N. Pavloff, Phys. Rev. Lett. 98, 210602 (2007)], we focus here on the supersonic stationary regime where Anderson localization exists. We generalize

Impact of low-dose prednisolone on bone synthesis and resorption in early rheumatoid arthritis: experiences from a two-year randomized study

Introduction Patients with rheumatoid arthritis (RA) have an increased frequency of osteoporosis, mainly because of increased bone resorption. Reduction of disease activity is suggested to reduce bone remodelling. It might also be possible that prednisolone treatment could cause this effect because prednisolone has been shown to arrest the development of joint destruction in early RA. Therefore, w

Mechanical Behavior of a Supported Lipid Bilayer under External Shear Forces.

Shear forces from a pressure-driven bulk flow in a microfluidic channel can be used to induce and control the motion of a supported lipid bilayer (SLB) formed on the walls of the channel. We here present a theoretical model that relates the experimentally observed drift velocities of an egg yolk phosphatidylcholine (egg PC) SLB to the hydrodynamic drag force from the bulk flow, the intermonolayer

BIRADS classification in breast tomosynthesis compared to mammography and ultrasonography

This paper presents the Malmo Breast tomosynthesis project The tomosynthesis equipment is described as well as the patient selection and image acquisition. Special fucus is given to one of the studies of the project, which is a comparison of the diagnostic performance between breast tomosynthesis (BT), digital mammography (DM) and ultrasonography (US): tumor classification according to the BIRADS