POU5F1, which encodes a transcriptional factor, has two alternatively spliced transcripts, 1 and 2, as well as six pseudogenes. Transcript 1 is considered to be a key regulator of cellular pluripotency and self-renewal. The POU5F1 pseudogene, POU5F1P1 on 8q24, encodes a protein with 95% homology with the isoform 1 of POU5F1. It is located 15 kbp downstream of the SNP rs6983267, which is strongly a

Background Preventive measures are needed to counteract the increasing burden of cutaneous malignant melanoma (CMM). As a basis for rational melanoma prevention, we investigated geographic differences and impact from socioeconomic factors related to incidence, clinical stage at diagnosis and outcome. Material and methods All patients with primary invasive CMM diagnosed in 2004-2013 in the southern

Davidoff-fallet samtyckets betydelse vid parallellhandel. Frågan gällde hur man avgör om en varumärkesinnehavare på ett bindande sätt samtyckt till import från tredje land. Måste medgivandet vara uttryckligt eller räcker det att rättsinnehavaren inte direkt förbjudit parallellimport? Utslaget har föregåtts av omfattande diskussion i juridisk litteratur och blev också föremål för stor uppmärksamhet

OBJECTIVES: Peripheral vascular disease (PVD) is an important limiting factor for healing in neuroischemic or ischemic diabetic foot ulcer. The purpose of this study was to identify factors related to healing in patients with diabetes with foot ulcers and severe PVD. METHODS: Patients with diabetes with a foot ulcer, consecutively presenting at a multidisciplinary foot center with a systolic toe p

It has been reported that 10-50% of patients with pruritus but no skin rash have an underlying systemic disease and up to 70% a psychiatric one. The aim of this retrospective study was to review the records of a large number of patients with chronic pruritus for concomitant diseases and treatment options. Medical records of 139 patients (52 males, 87 females) with chronic pruritus who visited the

Popular Abstract in Swedish Det första målet med detta arbete är att beskriva och diskutera järnålderssamhällets utveckling i Skåne. Det andra målet är att diskutera förhållandet mellan Skåne och angränsande områden. Järnålderssamhället var hierarkiskt uppbyggt och styrdes av olika typer av ledare, vanligen hövdingar eller kungar. Olika sociala grupper verkade i samhället för att bibehålla och utThe first purpose of this dissertation is to describe and discuss the development of the Iron Age society in Scania. The second purpose is to discuss the relations between Scania and the neighbouring areas. The Iron Age society was hierarchical and ruled by different types of leaders, usually cheiftains or kings. To maintain and develop the social system different social groups acted in society.

PURPOSE:: To examine the retinal inflammatory response to ischemia-reperfusion in nondiabetic and diabetic rats injected with either an omega-3-polyunsaturated fatty acid (docosahexaenoic acid [DHA]) or a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (pravastatin). METHODS:: Diabetes was induced by an intraperitoneal injection of streptozocin, and retinal ischemia was induced by ligati

The article "Missing female subjects. An analysis of medical texts about menopause" focuses on medical discourses about women and middle age. More concretely, it presents an analysis of articles in Läkartidningen from 1990 through 2001. Läkartidningen is the official journal of the Swedish Medical Association and has a distribution of nearly 30 000 copies. The analysis is based upon three qualitat

Purpose: Biokinetic and dosimetry studies in laboratory animals often precede clinical radionuclide therapies in humans. A reliable evaluation of therapeutic efficacy is essential and should be based on accurate dosimetry data from a realistic dosimetry model. The aim of this study was to develop an anatomically realistic dosimetry model for Brown Norway rats to calculate S factors for use in eva

Natural radiative lifetimes of 10 levels of singly ionized ytterbium have been measured with time-resolved laser spectroscopy. Free Yb+ ions were produced in a laser-induced plasma. A stimulated Brillouin scattering technique has been used to produce laser pulses as short as 1 ns for the excitation of short-lived Yb+ states. Pseudo-relativistic Hartree-Fock calculations, taking into account the co

This article aims to contribute to the critical examination of the notions of health and activity, and to discuss how these cultural and social constructs have impact on elderly people’s lives. An ethnographic perspective gives fruitful inputs to explore how old people deal with the image of old age as one of decay and decline, while they simultaneously relate to the normative idea of so-called su