Background: Non-motor symptoms (NMS) are integral to Parkinson's Disease (PD) and management remains a challenge. Safinamide is a novel molecule in relation to addressing NMS due to its multifocal mechanism of action with both dopaminergic and non-dopaminergic properties. Objective: To investigate the efficacy of safinamide on NMS and its burden in PD patients with motor fluctuations after 6 month

Globally, the twenty-first century will witness rapid population ageing. Already in 2050, one out of five persons in the world, and one out of three in Europe, is expected to be 60 or over (UN 2015). Moreover, we have entered into a new stage of population ageing in terms of its causes, which have altered its consequences. In the first stage, lasting until the middle of the twentieth century in de

Aims: To describe burden and health-related quality of life amongst caregivers of out-of-hospital cardiac arrest survivors and explore the potential association with cognitive function of the survivors. Caregivers of patients with ST-elevation myocardial infarction were used as controls. Methods: Data were collected from the cognitive substudy of the Targeted Temperature Management-trial. Caregive

Digital technologies have made it easier and more affordable to record, edit and circulate images. At the same time, visuals can provide scholarly insights beyond what may be documented and conveyed in writing. Nevertheless, visual methods still play a secondary role in humanistic and social science research.This book shows how visual methods can be used to approach difficult-to-access fields and Visuals can provide and communicate scholarly insights beyond what may be documented and conveyed in writing. However, despite digital technologies making it easier and more affordable to record, edit, and circulate images, visual methods still play secondary roles in humanistic and social science research.Based on a study of the tracks and traces left by graffiti writers in Malmö, Sweden, this bo

The conversion of technical lignin into valuable chemicals is important for the complete utilization of lignocellulose. The kraft process dominates the pulp industry, and large amounts of kraft lignin are produced worldwide. However, the complexity of lignin limits its valorization. In this study, a kraft lignin, Indulin AT, was depolymerized under base conditions, and the effects of substrate loa

Lärobok i makroekonomi för grundnivån

ObjectiveOpen and endovascular aortic repair may be complicated by aortic vascular graft or endograft infection (VGEI). Confirming the microbiological aetiology is a key element in providing the best available treatment to patients with a VGEI. The primary aim of this study was to describe the technique of direct aneurysm sac guided aspiration (DASGA) in determining the microbiological aetiology i

Sharing Cities Sweden was a national program to help establish Sweden as a country that actively and critically works with the sharing economy in cities. Between 2017- 2021, it was a key initiative of Viable Cities - the strategic innovation program for smart and sustainable cities in Sweden.Sharing Cities Sweden developed and published a diversity of reports and outputs that synthesize the activi

A general LCA model for the determination of the environmental effect of the incorporation of a flame retardant into a product has recently been developed and presented internationally. This model weights the benefits of choosing a high level of fire safety (in terms of fewer and smaller fires) against the environmental cost of the method used to attain this level of safety, i.e., the environmenta

Mercury (Hg) is a ubiquitous heavy metal that originates from both natural and anthropogenic sources and is transformed in the environment to its most toxicant form, methylmercury (MeHg). Recent studies suggest that MeHg exposure can alter epigenetic modifications during embryogenesis. In this study, we examined associations between prenatal MeHg exposure and levels of cord blood DNA methylation (

Fibrotic scar tissue limits central nervous system regeneration in adult mammals. The extent of fibrotic tissue generation and distribution of stromal cells across different lesions in the brain and spinal cord has not been systematically investigated in mice and humans. Furthermore, it is unknown whether scar-forming stromal cells have the same origin throughout the central nervous system and in

Finding ways to use limited resources to reach ambitious visions, what we call strategizing, is always a challenge. Possibly, the challenge is greater in public sector organizations aiming to fulfil a political vision for a future society. It is more challenging because public services have many and varied stakeholders and institutional arrangements and deliver different kinds of services and prod