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INTRODUCTION: Standard treatment of congenital haemophilia A is based on replacement therapy with coagulation factor VIII (FVIII) products. A major complication of FVIII therapy is the occurrence of IgG alloantibodies (inhibitors) that neutralize FVIII activity.AIM: The aim of the analysis was estimating the risk of high-titre inhibitor associated with the second-generation full-length product com

We present a case of a patient in a severe pulmonary mucormycosis during the neutropenic phase of treatment for acute myeloblastic leukaemia (AML), type M2. He had two major risk factors for setting infection; leukaemia and diabetes mellitus. Although he received antimicrobial and antifungal therapy with Amphotericin B in time, it was unable to eradicate infection. We performed a pneumectomy, whic

A 44-year-old patient with acute myeloid leukaemia (M5 type) who developed a saddle nose deformity during aplasia of induction therapy is described. The diagnosis of an infectious perichondritis of the nasal septum was established by thorough examination and review of the literature.

We do mean-field perturbation theory for U(1) lattice gauge theory in the axial gauge, and evaluate corrections from fluctuations up to fourth order for the free energy and plaquette energy. Comparing with similar results previously obtained in the Feynman gauge we find, to those orders studied, a gauge dependence of the size of the first correction term neglected with one exception. This gauge de

The self-similar structure of mode lockings for circle maps is studied by means of the associated Farey trees. We investigate numerically several classes of scaling relations implicit in the Farey organization of mode lockings and discuss the extent to which they lead to universal scaling laws.

We explore the possibility of reducing finite size effects in the weak coupling region of glueball correlations and Wilson loops. Our analysis indicates that twisted boundary conditions do diminish finite size effects and numerical evidence for this is given for the glueball correlation.

We study a model of random surfaces endowed with fermionic degrees of freedom. The critical parameters are estimated using a Monte Carlo simulation method, for the dimensionality d of the embedding space ranging from d=0 to d=10.

A novel modified method for obtaining approximate solutions to difficult optimization problems within the neural network paradigm is presented. We consider the graph partition and the travelling salesman problems. The key new ingredient is a reduction of solution space by one dimension by using graded neurons, thereby avoiding the destructive redundancy that has plagued these problems when using s