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OBJECTIVE: Determination of lactate in fetal scalp blood (FBS) during labour has been recognised since the 1970s. The internationally accepted cutoff of >4.8 mmol/l indicating fetal acidosis is exclusive for the point-of-care device (POC) LactatePro™, which is no longer in production. The aim of this study was to establish a new cutoff for scalp lactate based on neonatal outcomes with the use of t

The prevalence of avoidant/restrictive food intake disorder (ARFID) in the general child population is still largely unknown and validated screening instruments are lacking. The aims of this study were (1) to investigate the prevalence of children screening positive for ARFID in a Japanese birth cohort using a newly developed parent-reported screening tool, (2) to estimate the prevalence of childr

This paper presents a search for dark matter in the context of a two-Higgs-doublet model together with an additional pseudoscalar mediator, a, which decays into the dark-matter particles. Processes where the pseudoscalar mediator is produced in association with a single top quark in the 2HDM+a model are explored for the first time at the LHC. Several final states which include either one or two ch

Status Epilepticus (SE) is often a neurological emergency characterized by abnormally sustained, longer than habitual seizures. The new ILAE classification reports that SE “…can have long-term consequences including neuronal death, neuronal injury…depending on the type and duration of seizures”. While it is accepted that generalized convulsive SE exerts detrimental effects on the brain, it is not

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide and mostly affects men. Around 20% of its incidence is by familiar disposition due to hereditary syndromes. The CRC treatment involves surgery and chemotherapy; however, the side effects of treatments and the fast emergence of drug resistance evidence the necessity to find more effective drugs. Curcumin is the main polyp

Dronedarone may increase exposure and the risk of major bleeding when prescribed with a direct oral anticoagulant (DOAC). This retrospective cohort study examined the risk of the first occurrence of major bleeding (hospitalization or emergency room visit for gastrointestinal [GI] bleeding, intracranial hemorrhage [ICH], or bleeding at other sites) among new users of apixaban, dabigatran, and rivar

Adequate setting of the boundary conditions for the heat equation when modeling the temperature distribution in the cutting tool is one of the key points. The boundary conditions on the tool surfaces can be divided into two groups: conditions that describe heat losses (heat exchange with the environment) and conditions that characterize the heat source that heats up the tool (heat flux from the cu

Objective: To describe and compare hip and groin strength and function of male ice hockey players over one season in players with and without hip and groin problems in the previous season. Design: Prospective cohort study. Setting: Swedish male ice hockey. Participants: We followed 193 players from 10 teams during the 2017/2018 season. Main outcome measures: Hip adduction and abduction strength, 5

Background: Research investigating neuromotor function in the absence of cerebral palsy (CP) for children who had neonatal HIE is limited. Aims: To investigate school-age neurological and neuromotor function, and correlations with attention, neonatal Magnetic Resonance Imaging (MRI), and neuromotor assessments at toddler age. Methods: Twenty-seven children with neonatal HIE without CP who underwen

Context. 55 Cnc e is a transiting super-Earth (radius 1.88 R⊕ and mass 8 M⊕) orbiting a G8V host star on a 17-h orbit. Spitzer observations of the planet's phase curve at 4.5 μm revealed a time-varying occultation depth, and MOST optical observations are consistent with a time-varying phase curve amplitude and phase offset of maximum light. Both broadband and high-resolution spectroscopic analyses

Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortco

BACKGROUND: People with mental illness may have difficulties related to work and employment, especially if they experience additional difficult life situations. OBJECTIVE: To explore how subgroups with mental illness and additional adversities perceived their situation with respect to work and employment prospects. METHODS: Three subgroups were included, exposed to an additional difficult life sit

Iron and steel production is responsible for 7% of global greenhouse gas emissions. Earlier literature finds that the long economic life of steel production equipment impedes decarbonization in line with climate targets. Here, we estimate the cumulative emissions from existing primary steel production equipment if operated as historically observed, based on furnace-level data of historical operati

The growing menace of global warming and restrictions on access to water in each region is a huge threat to global hydrological sustainability. Hence, the perspective at which hydrological studies are currently being carried out across the world to quantify and understand the water cycle modeling requires a further boost. In the past few decades, the theoretical understanding of machine learning (

Introduction: Gender affirming surgery of primary and/or secondary sex characteristics has been shown to alleviate gender dysphoria. A descriptive snapshot of current treatment preferences is useful to understand the needs of the transgender population seeking health care. This study aimed to describe preferences for gender affirming treatment, and their correlates, among individuals seeking healt

Myocardin related transcription factors (MRTFs: MYOCD/myocardin, MRTF-A, and MRTF-B) play a key role in smooth muscle cell differentiation by activating contractile genes. In atherosclerosis, MRTF levels change, and most notable is a fall of MYOCD. Previous work described anti-inflammatory properties of MRTF-A and MYOCD, occurring through RelA binding, suggesting that MYOCD reduction could contrib