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Both abundant epidermal growth factor receptor (EGFR or ErbB1) and high activity of the phosphatidylinositol 3-kinase (PI3K)-Akt pathway are common and therapeutically targeted in triple-negative breast cancer (TNBC). However, activation of another EGFR family member [human epidermal growth factor receptor 3 (HER3) (or ErbB3)] may limit the antitumor effects of these drugs. We found that TNBC cell

Activating mutations of the PIK3CA gene occur frequently in breast cancer, and inhibitors that are specific for phosphatidylinositol 3-kinase (PI3K) p110α, such as BYL719, are being investigated in clinical trials. In a search for correlates of sensitivity to p110α inhibition among PIK3CA-mutant breast cancer cell lines, we observed that sensitivity to BYL719 (as assessed by cell proliferation) wa

The present study investigated concordance between representations of attachment to mother and attachment to father, and convergence between two narrative-based methods addressing these representations in middle childhood: the Manchester Child Attachment Story Task (MCAST) and the Secure Base Script Test (SBST). One hundred and twenty 6-year-old children were assessed by separate administrations o

Multilevel data occurs frequently in many research areas like health services research and epidemiology. A suitable way to analyze such data is through the use of multilevel regression models (MLRM). MLRM incorporate cluster-specific random effects which allow one to partition the total individual variance into between-cluster variation and between-individual variation. Statistically, MLRM account

The use of very large instrumentation, usually called Big Science, became an important part of Western science systems after World War II, with nuclear and particle physics at the center. Throughout the Cold War era, however, science policy priorities and objectives gradually shifted and in parallel therewith, new uses of Big Science emerged that were oriented to the study of materials and later a

Rhabdom adaptation and its phylogenetic significance. Zool. Scr. 5 (3–4): 97–101, 1976. — The rhabdoms of arthropod compound eyes are structurally differentiated into open, fused layered, and fused continuous. All are capable of perceiving polarized light. The fused layered, and under certain conditions the fused continuous, perform particularly well. — The fused layered rhabdoms occur in malacost

Certain neurons in the nervous system of the malacostracan crustaceans give rise to a predominantly green and a sparse yellow fluorophore in the histochemical fluorescence method of Falck-Hillarp. The same applies to the whole of Crustacea. The green fluorophore is probably a catecholamine; the yellow to brown-yellow has not yet been identified.The biogenic amine responsible for the green fluoresc

A comparative investigation of the distribution of monoaminergic neurons in non-malacostracan crustaceans was performed with the histochemical fluorescence method of Falck-Hillarp.Two fluorophores were found: the more widespread of the two emits a green fluorescence; and the more sparsely distributed emits a yellow to brown-yellow fluorescence.Specific green fluorescent areas were shown to exist i

The ommatidia of the compound eyes of Artemia salina L. are normally composed of four crystalline cone cells containing glycogen. The cells are enveloped by two so-called “cellules épidermiques juxta-cristallines”. There are also six pigmented retinula cells, all contributing to the rhabdom.A peculiar feature of the Artemia crystalline cone cells is that their elongated parts, the so-called cone c

The pigment cells of the compound eye of the shrimps (Crangon crangon andC. allmani) were studied by electron microscopy (SEM and TEM) and microspectrophotometry. The compound eyes of these species contain light-absorbing and -reflecting pigments contained in granules, located in 5 different cells. The light absorbing pigment granules (light screen) are situated in (1) the distal pigment cells, (2

Eltringham's organ is a club-like projection from the posterior margin of hind-wings of some myrmeleontid insects. It bears laterally directed setae, each having a specialized epidermal cell beneath, which gives off secretion into a sub-setal lumen. The lumen continues into the wall of the moat-like socket of the setae. Eltringham's organ fits into an excavation of the lateral body wall connected

Chromatophores, with chemically identified pigment, from the body and eyes of crustaceans were investigated ultrastructurally. Red carotenoid-, black ommochrome-, and white pteridine-containing chromatophores were found to have pigment granules of different morphological appearance.

The ultrastructure of the primary pigment cells of the compound eye of Lepisma saccharina is described. The cells are four in number. The pigment granules are contained in fingerlike protrusions from the pigment cells. These protrusions project into the enlarged basal lamina surrounding the ommatidial top. The large basal lamina could have given the impression of a cell (called corneagen) in the l

With the fluorescence method of Falck and Hillarp, the presence and localization of monoaminergic neurons in the optic ganglia of several crustaceans and insects have been investigated. It was found that in both classes the monoaminergic terminals, when present, appeared (especially in the medullae externa and interna of the crustaceans and the medulla of the insects) in strata specific for each s

A study was made on the penetration and cellular uptake of two protein tracers, albumin labelled with Evans blue (EBA) and horseradish peroxidase (HP), in the nervous system of the crayfish following systemic and local administration. Followingsystemic injection, EBA did not diffuse freely from the cerebral vessels into the brain parenchyma. When the tracers werelocally applied on the surface of t

The ultrastructure of the paired nerves, previously called frontal organ or X-organ, in copepod crustaceans was investigated. These nerves, run- ning from the anterior margin of the brain to the frontal edge of the animals, are found to contain the dendrites of three types of morpho- logically different sensory neurons. The first unit consists of two dendrites (distinguished by their myelinization