OBJECTIVE: The mechanisms underlying the association between diabetes and inner ear dysfunction are not known yet. The aim of the present study is to evaluate the impact of obesity/insulin resistance on inner ear fluid homeostasis in vivo, and to investigate whether the organ of Corti could be a target tissue for insulin signaling using auditory House Ear Institute-Organ of Corti 1 (HEI-OC1) cells

This paper reports on CFD simulations of in-cylinder flow and combustion in an open-bowl heavy duty diesel engine at high load. The focus of the study is to unravel the effect of swirl motion on the soot formation and on the late cycle soot oxidation. To incorporate detailed kinetic mechanism while maintaining a manageable computational time, Representative Interactive Flamelets (RIF) method is em

An acoustically levitated droplet has been used to collect synchrotron SAXS data on human serum albumin protein solutions up to a protein concentration of 400mgml-1. A careful selection of experiments allows for fast data collection of a large amount of data, spanning a protein concentration/solvent concentration space with limited sample consumption (down to 3μL per experiment) and few measuremen

This study investigates the potential for Electrical Resistivity Tomography (ERT) to detect buried glass ‘hotspots’ in a glass waste dump based on results from an open glass dump investigated initially. This detection potential is vital for excavation and later use of buried materials as secondary resources. After ERT, test pits (TPs) were excavated around suspected glass hotspots and physico-chem

PURPOSE: The presence of neovascular age-related macular degeneration (nAMD) in one eye is a major risk factor for the development of disease in the fellow eye. Several methods exist to help physicians monitor the fellow eye, with new technologies becoming increasingly available. METHODS: We provide an overview of modalities for nAMD monitoring, including advances in home-based options, and review

BACKGROUND: Elderly patients with acute myocardial infarction undergoing percutaneous coronary intervention are at increased risk of both ischemic and bleeding complications. The optimal anticoagulation strategy in these patients is uncertain. Therefore, we compared bivalirudin to heparin monotherapy in a contemporary cohort of such patients. METHODS: A prespecified subgroup analysis of elderly pa

We present 783 surgical resections of typical and atypical carcinoid tumors of the lung identified in the pathology files of 20 different pathology departments. All cases were critically reviewed for clinical and pathological features and further correlated with clinical outcomes. Long-term follow-up was obtained in all the patients and statistically analyzed to determine significance of the diffe

Preeclampsia (PE), is a pregnancy related condition afflicting 3-8% of all pregnancies and a main cause of maternal and infant morbidity and mortality. It is thought to originate from a malfunctioning placental that eventually leads to damage to the maternal endothelium, which in turn gives rise to hypertension and organ dysfunction. Oxidative stress holds a central role in the development, progre

OBJECTIVES: Infantile hemangiomas (IHs) are common; some cases require timely referral and treatment to prevent complications. We developed and validated a reliable instrument for timely and adequate referral of patients with IH to experts by nonexpert primary physicians. METHODS: In this multicenter, cross-sectional, observational study, we used a 3-stage process: (1) development of the Infantile

Objective: Epidemiological studies have found air pollution to be a driver of adverse pregnancy outcomes, including gestational diabetes, low term birth weight and preeclampsia. It is unknown what biological mechanisms are involved in this process. A first trimester trophoblast cell line (HTR-8/SVneo) was exposed to various concentrations of PM2.5 (PM2.5) in order to elucidate the effect of urban

Efficient and sustainable mobility is becoming a need for emerging metropolitan areas, essential to grant their attractiveness, quality of life and economic power. Among the possible strategies to adopt, shared mobility systems have proven to be a valuable alternative to accommodate the mobility needs of citizens ensuring at the same time sustainability and transport flexibility. In particular, th

We estimate that there will be 13·7 million new cases of childhood cancer globally between 2020 and 2050. At current levels of health system performance (including access and referral), 6·1 million (44·9%) of these children will be undiagnosed. Between 2020 and 2050, 11·1 million children will die from cancer if no additional investments are made to improve access to health-care services or childh

According to the Global Burden of Disease study, occupational exposures to particulates, gases and fumes were responsible for 0.36 million deaths and 8.8 million disability-adjusted life years globally in 2015. This thesis focuses on two occupational groups that are at risk for developing adverse health effects from the time they spend in their working environments: cleaning workers and workers in

Background: Hip fractures are common in older individuals entailing considerable risk of morbidity and mortality. Instruments are needed to enhance risk stratification of hip fracture patients. There is limited knowledge of the role of biomarkers as risk prognosticators for mortality in hip fracture patients.Aims: We assessed how well two well known risk stratification tools performed in a cohort

Cardiorespiratory monitoring is crucial for the diagnosis and management of multiple conditions such as stress and sleep disorders. Therefore, the development of ambulatory systems providing continuous, comfortable, and inexpensive means for monitoring represents an important research topic. Several techniques have been proposed in the literature to derive respiratory information from the ECG sign